Understanding anesthesia: making genetic sense of the absence of senses

Humphrey, J. A.

doi:10.1093/hmg/11.10.1241

Cited by 34Anesthesia and Sedative AgentsAnesthesia and Neurotoxicity ResearchNeurobiology and Insect Physiology Research

Understanding anesthesia: making genetic sense of the absence of senses

Humphrey, J. A.·2002·Human Molecular Genetics

DOI 10.1093/hmg/11.10.1241

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Abstract

The discovery of the phenomenon of anesthesia over 150 years ago was a watershed event that revolutionized the practice of medicine. Despite their annual use in millions of patients, the mechanism by which volatile anesthetics produce reversible loss of consciousness remains a mystery. The inherent problems in studying loss of consciousness in humans are legion. However, multiple model organisms are currently being exploited to apply the powerful tools of modern molecular genetics to this question. Mutants in yeast, nematodes, fruit flies and mice have been produced that display abnormalities in their response to volatile anesthetics. Each organism possesses unique advantages and difficulties as a model system, and each reveals different molecules that control its response to anesthetics. Nonetheless, the accumulating body of genetic evidence points to multiple targets for volatile anesthetics. Not only will understanding how volatile anesthetics work yield better and safer anesthetics, but, in addition, these remarkable compounds may ultimately serve as probes to understand the nature of consciousness itself.

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No single gene mutation completely removes volatile anesthetic responsiveness.
“no single gene mutation fully ablates volatile anesthetic responsiveness.”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [12]

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Sorted by citations

The Biology of General Anesthesia from Paramecium to Primate
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Background
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Authors: Humphrey, J. A.
Affiliations: University Hospitals of Cleveland (US)
Corresponding author: Humphrey, J. A.
Venue: Human Molecular Genetics
Publisher: Oxford University Press (OUP)
Published: 2002-05-15
Volume: 11
Issue: 10
Pages: 1241-1249
ISSN: 0964-6906 (ISSN-L)
1460-2083
DOI: 10.1093/hmg/11.10.1241
OpenAlex: W2149655090
Cited by: 34
References: 68
Citations by year: 2024: 1 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
FWCI: 0.65
Type: journal article
Language: en
Open access: closed
Locations: Human Molecular Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (GM45402, GM58881, R01GM045402, R01GM058881)
Topics: Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: anesthesia, volatile anesthetics, loss of consciousness, anesthetic targets, consciousness, anesthetic mechanisms
MeSH terms: Anesthesia, Anesthetics, Animals, Drosophila melanogaster, Humans, Saccharomyces cerevisiae, Caenorhabditis elegans, Mice

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Understanding anesthesia: making genetic sense of the absence of senses

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