Neurobiology of the Caenorhabditis elegans Genome

Bargmann, Cornelia I.

doi:10.1126/science.282.5396.2028

Cited by 929Neurobiology and Insect Physiology ResearchNeuroscience and Neuropharmacology ResearchIon channel regulation and function

Neurobiology of the Caenorhabditis elegans Genome

Bargmann, Cornelia I.·1998·Science

DOI 10.1126/science.282.5396.2028

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Abstract

Neurotransmitter receptors, neurotransmitter synthesis and release pathways, and heterotrimeric GTP–binding protein (G protein)–coupled second messenger pathways are highly conserved between Caenorhabditis elegans and mammals, but gap junctions and chemosensory receptors have independent origins in vertebrates and nematodes. Most ion channels are similar to vertebrate channels but there are no predicted voltage-activated sodium channels. The C. elegans genome encodes at least 80 potassium channels, 90 neurotransmitter-gated ion channels, 50 peptide receptors, and up to 1000 orphan receptors that may be chemoreceptors. For many gene families, C. elegans has both conventional members and divergent outliers with weak homology to known genes; these outliers may provide insights into previously unknown functions of conserved protein families.

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Authors: Bargmann, C. I.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Bargmann, Cornelia I.
ORCID: Bargmann, Cornelia I.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-12-11
Volume: 282
Issue: 5396
Pages: 2028-2033
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.282.5396.2028
OpenAlex: W2079441999
Semantic Scholar: 754ea421378363ec440d9ba7d927a2c83ea5b894
Cited by: 929
References: 76
Citations by year: 2026: 11 · 2025: 27 · 2024: 34 · 2023: 25 · 2022: 42 · 2021: 25 · 2020: 32 · 2019: 25 · 2018: 26 · 2017: 26 · 2016: 12 · 2015: 21 · 2014: 26 · 2013: 29 · 2012: 30
FWCI: 7.40
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: Caenorhabditis elegans, genome, neurobiology, neurotransmitter receptors, neurotransmitter synthesis, neurotransmitter release, G protein-coupled receptors, second messengers, gap junctions, chemosensory receptors, ion channels, potassium channels, neurotransmitter-gated ion channels, peptide receptors, orphan receptors, chemoreceptors, gene family evolution, comparative genomics
MeSH terms: Animals, Ion Channels, Nervous System Physiological Phenomena, Neuronal Plasticity, Neurons, Receptors, Cell Surface, Sensory Receptor Cells, Synapses, Genome, Caenorhabditis elegans, Genes, Helminth, Gap Junctions, Neurotransmitter Agents, GTP-Binding Proteins

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Neurobiology of the Caenorhabditis elegans Genome

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