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Negative Regulation and Gain Control of Sensory Neurons by the C. elegans Calcineurin TAX-6
Open accessAbstract
Animals sense and adapt to variable environments by regulating appropriate sensory signal transduction pathways. Here, we show that calcineurin plays a key role in regulating the gain of sensory neuron responsiveness across multiple modalities. C. elegans animals bearing a loss-of-function mutation in TAX-6, a calcineurin A subunit, exhibit pleiotropic abnormalities, including many aberrant sensory behaviors. The tax-6 mutant defect in thermosensation is consistent with hyperactivation of the AFD thermosensory neurons. Conversely, constitutive activation of TAX-6 causes a behavioral phenotype consistent with inactivation of AFD neurons. In olfactory neurons, the impaired olfactory response of tax-6 mutants to an AWC-sensed odorant is caused by hyperadaptation, which is suppressible by a mutation causing defective olfactory adaptation. Taken together, our results suggest that stimulus-evoked calcium entry activates calcineurin, which in turn negatively regulates multiple aspects of sensory signaling.
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“Yet, C. elegans CFAP-20 participates in several sensory and physiological processes that depend on various types of non-motile cilia: ability to sense and learn to avoid salt in the absence of food (gustatory plasticity); lifespan control; locomotion (roaming); and, body size determination40,42,47–51.”
From The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision (2022) · cites this paper as [51]
Citations
Cites
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,220
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116
Mello, C. C., Kramer, J. M., Stinchcomb, D. T., & Ambros, V. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04966.x · Cited by 3,095
THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES
Cohen, P. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.002321 · Cited by 2,543
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
Clipstone, N. A., & Crabtree, G. R. (1992) · Nature · doi:10.1038/357695a0 · Cited by 1,635
A capsaicin-receptor homologue with a high threshold for noxious heat
Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J., & Julius, D. J. (1999) · Nature · doi:10.1038/18906 · Cited by 1,599
Odorant-selective genes and neurons mediate olfaction in C. elegans
Bargmann, C. I., Hartwieg, E. A., & Horvitz, H. R. (1993) · Cell · doi:10.1016/0092-8674(93)80053-h · Cited by 1,234
Ca 2+ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD
Wang, H., Pathan, N., Ethell, I. M., Krajewski, S., Yamaguchi, Y., Shibasaki, F., McKeon, F., Bobo, T., Franke, T. F., & Reed, J. C. (1999) · Science · doi:10.1126/science.284.5412.339 · Cited by 1,132
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
O’Keefe, S. J., Tamura, J., Kincaid, R. L., Tocci, M. J., & O’Neill, E. A. (1992) · Nature · doi:10.1038/357692a0 · Cited by 841
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Pereira, S., & van der Kooy, D. (2013) · Worm · doi:10.4161/worm.22725 · Cited by 8
A negative feedback loop in the GPCR pathway underlies efficient coding of external stimuli
Ruach, R., Yellinek, S., Itskovits, E., Deshe, N., Eliezer, Y., Bokman, E., & Zaslaver, A. (2022) · Molecular Systems Biology · doi:10.15252/msb.202110514 · Cited by 5
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Song, H., Lee, J., Ji, Y. J., Dwivedi, M., Cho, J. H., Park, B.-J., & Ahnn, J. (2010) · Molecules and Cells · doi:10.1007/s10059-010-0116-x · Cited by 8
Hu, Y., Sun, Y., Ye, B., & Wang, D. (2007) · Neuroscience Bulletin · doi:10.1007/s12264-007-0002-5 · Cited by 8
Li, W., Choi, T.-W., Ahnn, J., & Lee, S.-K. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.0222 · Cited by 6
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Bye‐A‐Jee, H., Zaru, R., Magrane, M., & Orchard, S. E. (2020) · FEBS Journal · doi:10.1111/febs.15213 · Cited by 7
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Aoki, I., Nakano, S., & Mori, I. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.21096-1 · Cited by 6
Self-citationHee, K. Y., Song, H., Min, K. K., Gunasekaran, S., Jee, C., Junsu, K., & Joohong, A. (2008) · Molecules and Cells · doi:10.1016/s1016-8478(23)17619-9 · Cited by 6
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Ikejiri, Y., Tanimoto, Y., Fujita, K., Hiramatsu, F., Yamazaki, S. J., Endo, Y., Iwatani, Y., Fujimoto, K., & Kimura, K. D. (2023) · Neuroscience Research · doi:10.1016/j.neures.2023.01.006 · Cited by 4
Rudgalvyte, M., Hu, Z., Kressler, D., Dengjel, J., & Glauser, D. A. (2025) · eLife · doi:10.7554/elife.103497 · Cited by 5
Das, P., Aballay, A., & Singh, J. (2023) · eLife · doi:10.7554/elife.89572.3 · Cited by 15
Buddawong, T., Asuvapongpatana, S., Senapin, S., McDougall, C., & Weerachatyanukul, W. (2020) · PeerJ · doi:10.7717/peerj.8868 · Cited by 4
Calcineurin may regulate multiple endocytic processes in C. elegans
Song, H., & Ahnn, J. (2011) · BMB Reports · doi:10.5483/bmbrep.2011.44.2.96 · Cited by 3
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(2013) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-415823-8.00011-3 · Cited by 3
Fitzpatrick, D. A., & O’Halloran, D. M. (2012) · International Journal of Evolutionary Biology · doi:10.1155/2012/548081 · Cited by 3
(2014) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 3
Xianglan, C., Ko, K., Singaravelu, G., & Ahnn, J. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.6.455 · Cited by 2
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Brown, A. L., Ramot, D., & Goodman, M. B. (2007) · Springer series in biophysics · doi:10.1007/978-3-540-72739-2_10 · Cited by 2
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Kuhara, A., & Mori, I. (2008) · Seibutsu Butsuri · doi:10.2142/biophys.48.167 · Cited by 1
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MD, P. D. (2006) · CRC Press eBooks · doi:10.1201/9781420005844-25 · Cited by 1
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Ko, Y. J., Chang, H., & Lee, D. H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1079-2_89 · Cited by 1
Pleiotropic Effects of Taurine on Nematode Model for Down Syndrome
Chang, H., & Lee, D. H. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-8023-5_40 · Cited by 1
TRP Channel Functioning in Mating and Fertilization
Xu, X. S., & Barr, M. M. (2006) · Frontiers in neuroscience · doi:10.1201/9781420005844.ch19 · Cited by 1
Molecular Physiological Mechanism of Temperature Response in Nematode C. elegans
Kuhara, A. (2012) · Seibutsu Butsuri · doi:10.2142/biophys.52.200 · Cited by 1
Self-citationDas, P., Aballay, A., & Singh, J. (2024) · eLife · doi:10.7554/elife.89572.2 · Cited by 1
Rudgalvyte, M., Hu, Z., Kressler, D., Dengjel, J., & Glauser, D. A. (2025) · eLife · doi:10.7554/elife.103497.2 · Cited by 1
Experience-Dependent Gain Modulation Drives Thermosensory Responses in BehaviorPreprint
García, M. D., Beagan, J., Cabezas-Bou, E., Thomas, M., Kumar, S., Shao, L., Fu, X., Cuentas-Condori, A., McVay, J. R., Hawk, J. D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.12.724589 · Cited by 1
Bates, S. G., Harris, N., Nurrish, S., & Sengupta, P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.14.725236 · Cited by 1
Kuhara, A., Ujisawa, T., & Ohta, A. (2015) · Hikaku seiri seikagaku(Comparative Physiology and Biochemistry) · doi:10.3330/hikakuseiriseika.32.67
Self-citationWorming to Complete the Insulin/IGF-1 Signaling Cascade: A Dissertation
Padmanabhan, S. (2009) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/40am-yf26
Regulación transcripcional dependiente de calcio en el sistema nervioso
Naranjo, J. R., & Gómez‐Villafuertes, R. (2009) · Dialnet (Universidad de la Rioja)
Identification of guanylyl cyclases that function in thermosensory neurons of
Inada, H., Itô, H., Satterlee, J. S., Sengupta, P., & Mori, I. (2006)
Self-citationWorkshop on the Calcium/Calcineurin/NFAT Pathway: Regulation and Function
Aramburu, J. F., Heitman, J., & Crabtree, G. R. (2004)
Navigating toward an Understanding of the Role of Regulator of Calcineurin in Thermotaxis
Kingsbury, T. J. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.09.004
Neural processing mechanism underlying temperature response of nematode Caenorhabditis elegans
Ohnishi, N., & Kuhara, A. (2012) · Hikaku seiri seikagaku(Comparative Physiology and Biochemistry) · doi:10.3330/hikakuseiriseika.29.112
Self-citationGenomics of Invertebrate Olfaction
Bohbot, J. D., Pitts, R. J., & Zwiebel, L. J. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00112-2
Mechanisms of Olfactory Plasticity in Caenorhabditis Elegans
Cho, C. (2025) · Digital Commons - RU (Rockefeller University) · doi:10.48496/7j5q-dk02
Changes emerging with calcinerin inhibition in Caenorhabditis elegans individuals as an aging model
Tosun, M., Hayta, S. B., Güner, R. Y., Akyol, M., & Özçelik, S. (2017) · Cumhuriyet Tıp Dergisi/Cumhuriyet Üniversitesi Tıp Fakültesi dergisi · doi:10.7197/223.v39i31705.347448
[Molecular and cell biological mechanism of olfactory adaptation in Caenorhabditis elegans].
Zhang, X., & Kang, L. (2018) · PubMed Central · doi:10.3785/j.issn.1008-9292.2018.06.15
A GPCR negative feedback loop underlies efficient coding of external stimuliPreprint
Ruach, R., Yellinek, S., Itskovits, E., & Zaslaver, A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.14.422627
Olfactory Discrimination in Caenorhabditis elegans
MacKay-Clackett, I. (2020) · TSpace (University of Toronto)
Garrity, P. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1159546.619927
Rudgalvyte, M., Hu, Z., Kressler, D., Dengjel, J., & Glauser, D. A. (2025) · eLife · doi:10.7554/elife.103497.1
eIF4E assembly into C. elegans germ granules is essential for its repressive functionPreprint
Sandoval, C. H., Borchers, C., Yang, B., Boyd, B., Hundley, H. A., & Aoki, S. T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.24.678427
Rudgalvyte, M., & Glauser, D. A. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011884
Florin, F. (2022) · theses.fr (ABES) · doi:10.70675/a9ac70abz7cc3z4633za40bzd3af32d3ca62
Dynamics of Erythropoietic Survival Pathways In Vivo: A Dissertation
Koulnis, M. (2011) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/7mft-d562
Metadata
- Authors
- Kuhara, A., Inada, H., Katsura, I., & Mori, I.
- Affiliations
- Nagoya University (JP)
- National Institute of Genetics (JP)
- Corresponding author
- Mori, Ikue
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 33
- Issue
- 5
- Pages
- 751-763
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2019816797
- Cited by
- 153
- References
- 57
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 10 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 8
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Economía y Competitividad
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- calcineurin, sensory neurons, gain control, negative regulation, thermosensation, AFD neurons, olfactory adaptation, olfactory sensory neurons, AWC neurons, sensory transduction, calcium influx, Caenorhabditis elegans
- MeSH terms
- Pentanols, Amino Acid Sequence, Animals, Humans, Ion Channels, Locomotion, Models, Biological, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Afferent, Osmolar Concentration, Phenotype, Recombinant Fusion Proteins, Smell, Thermosensing, Signal Transduction, Sequence Alignment, Caenorhabditis elegans, Calcineurin, Protein Subunits, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Transient Receptor Potential Channels, TRPV Cation Channels
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