Current Compensation in Neuronal Homeostasis
Open accessAbstract
How do neurons maintain stable intrinsic properties over long periods of time as the channels that govern excitability turn over in the membrane? In this issue of Neuron, MacLean et al. argue that homeostatic regulation of intrinsic activity can occur by an activity-independent mechanism.
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Destabilizing influences on neural circuits are counterbalanced by homeostatic plasticity mechanisms that stabilize neuronal and circuit activity.
“Recent work has shown that these destabilizing influences are counterbalanced by homeostatic plasticity mechanisms that act to stabilize neuronal and circuit activity.”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Marder and Prinz 2003
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The self-tuning neuron: synaptic scaling of excitatory synapses
Turrigiano, G. G. (2008) · Cell · doi:10.1016/j.cell.2008.10.008 · Cited by 1,533 · see citing works
Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function
Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139 · see citing works
HOMEOSTATIC CONTROL OF NEURAL ACTIVITY: From Phenomenology to Molecular Design
Davis, G. W. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135751 · Cited by 543 · see citing works
Multiple Modes of Network Homeostasis in Visual Cortical Layer 2/3
Maffei, A., & Turrigiano, G. G. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5298-07.2008 · Cited by 282 · see citing works
Tripodi, M., Evers, J. F., Mauss, A., Bate, M., & Landgraf, M. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060260 · Cited by 124 · see citing works
Sokolova, I. V., Schneider, C. J., Bezaire, M., Soltesz, I., Vlkolinsky, R., & Nelson, G. A. (2015) · Radiation Research · doi:10.1667/rr13785.1 · Cited by 62 · see citing works
Hyperexcitability and homeostasis in fragile X Syndrome.
Liu, X., Kumar, V., Tsai, N.-P., & Auerbach, B. D. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.805929 · Cited by 53 · see citing works
- Authors
- Marder, E., & Prinz, A. A.
- Affiliations
- Brandeis University (US)
- Corresponding author
- Marder, Eve
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 37
- Issue
- 1
- Pages
- 2-4
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2087501518
- Cited by
- 80
- References
- 0
- Citations by year
- 2025: 7 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 1
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3850 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- neuronal homeostasis, intrinsic excitability, membrane channels
- MeSH terms
- Action Potentials, Animals, Feedback, Homeostasis, Humans, Ion Channels, Nerve Net, Synaptic Transmission, Neurons, Ganglia, Invertebrate
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