The self-tuning neuron: synaptic scaling of excitatory synapses
Open accessAbstract
Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of all of a neuron's excitatory synapses up or down to stabilize firing. Current evidence suggests that neurons detect changes in their own firing rates through a set of calcium-dependent sensors that then regulate receptor trafficking to increase or decrease the accumulation of glutamate receptors at synaptic sites. Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales.
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The existence of LTD avoids the problem of saturation, which could be essential for a mnemonic device.
“The existence of LTD avoids the problem of saturation, which could be essential for a mnemonic device (366–371).”
From Synaptic memory and CaMKII (2023) · cites this paper as [368]
In “The Stability Problem” (page unavailable), the paper groups LTP and LTD as learning-related plasticity mechanisms, then says such mechanisms can create destabilizing feedback that drives neuronal activity to saturation. It says nervous systems need other plasticity mechanisms to counteract those forces; it does not say that the existence of LTD avoids saturation. (LLM, conf=0.86)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe firing rate set point is an emergent property that represents the stable point of all the opposing signaling pathways that operate on synaptic strength.
“One interesting implication of this model is that the firing rate set point is an emergent property that represents the stable point of all the opposing signaling pathways that operate on synaptic strength (Turrigiano 2008).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Turrigiano 2008
In Concluding Remarks, the paper proposes that the activity set point could arise where opposing forces regulating receptor accumulation equalize. The citing sentence presents this proposed model as fact and extends it to all opposing signaling pathways that affect synaptic strength, which the passage does not establish. (LLM, conf=0.87)
Experimental — accuracy not yet measuredIf the contribution of CaMKII to synaptic transmission were a net gain that simply adds onto the preexisting excitatory drive of the cell, the system would be unstable and quickly saturate.
“If this were the case, it has been argued that the system would be unstable and quickly saturate (366–371).”
From Synaptic memory and CaMKII (2023) · cites this paper as [368]
In “The Stability Problem” (page not provided), the paper argues that unconstrained strengthening of excitatory synapses creates positive feedback that can drive neuronal activity to saturation. It does not make that argument specifically about a net additive contribution from CaMKII; its discussion of CaMKII in “Signaling Pathways Underlying Synaptic Scaling” concerns different homeostatic effects. (LLM, conf=0.84)
Experimental — accuracy not yet measuredSynaptic scaling involves postsynaptic changes in receptor accumulation.
“It is widely agreed that synaptic scaling involves postsynaptic changes in receptor accumulation (Turrigiano 2008), but under some circumstances additional presynaptic changes can also be recruited (Davis and Bezprozvanny 2001;Rich and Wenner 2007;Thiagarajan et al. 2007).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Turrigiano 2008
Homeostasis occurs on a slower timescale of many hours or days; the cell senses excess activity and through a cellwide mechanism scales down all synapses in a multiplicative manner to restore excitatory drive to a set point.
“The third mechanism, homeostasis, occurs on a slower timescale of many hours or days (368). In this case the cell senses the excess level of activity and through a cellwide mechanism scales down all synapses in a multiplicative manner to restore excitatory drive to a set point.”
From Synaptic memory and CaMKII (2023) · cites this paper as [368]
In response to chronic hyperactivity or hypoactivity, neurons can engage homeostatic scaling-down or scaling-up respectively, in which the strength of excitatory synapses on a neuron is globally modified to maintain neuronal activity in a physiological range.
“In response to chronic hyperactivity or hypoactivity, neurons can engage homeostatic scaling-down or scaling-up respectively, in which the strength of excitatory synapses on a neuron is globally modified to maintain neuronal activity in a physiological range (O'Brien et al., 1998, Turrigiano et al., 1998, Turrigiano, 2008).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Turrigiano, 2008
Hebbian plasticity, including LTP and LTD, provoke positive feedback responses and are potentially prone to instability.
“Hebbian plasticity, including LTP and LTD, provoke positive feedback responses and are potentially prone to instability (Turrigiano, 2008; Vitureira and Goda, 2013).”
From The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning (2017) · cites this paper as Turrigiano, 2008
FMRP might participate in homeostatic synaptic plasticity by suppressing activity-driven translation, creating a feedback loop that restrains neuronal responses.
“These observations suggest that FMRP may play a role in homeostatic synaptic plasticity (Turrigiano, 2008). In this model, FMRP would act to repress the translation stimulated by neuronal activity to generate a feedback loop limiting neuronal responses to activity at the level of the neuron rather than a specific synapse.”
From FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism (2011) · cites this paper as Turrigiano, 2008
Mechanisms of synaptic homeostasis and plasticity to maintain the number of synapses in check, as well as sparse coding, may be direct consequences of a limiting and size-invariant, fixed energy budget per neuron.
“Thus, mechanisms of synaptic homeostasis [62] and plasticity to maintain the number of synapses in check (including the decrease of synaptic markers during sleep [63]), as well as sparse coding, with only a small proportion of neurons firing at high frequencies at any moment [49], [64], [65], may be direct consequences to brain function of a limiting and size-invariant, fixed energy budget per”
From Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution (2011) · cites this paper as [62]
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Cites
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works
Synaptic Activity and the Construction of Cortical Circuits
Katz, L. C., & Shatz, C. J. (1996) · Science · doi:10.1126/science.274.5290.1133 · Cited by 3,048 · see citing works
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588 · see citing works
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485 · see citing works
Self-citationSynaptic plasticity: taming the beast
Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263 · cited 7× · see citing works
“, 2008), but it is not possible to rule out effects on the many other forms of Hebbian or homeostatic plasticity that have been identified in cortical neurons (Abbott and Nelson, 2000; Desai, 2003; Maffei and Turrigiano, 2008; Sjostrom et al., 2006).”
BackgroundInfluentialActivity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226 · see citing works
Self-citationThe molecular basis of CaMKII function in synaptic and behavioural memory
Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn753 · Cited by 1,860 · see citing works
Metaplasticity: the plasticity of synaptic plasticity
Abraham, W. C., & Bear, M. F. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80018-x · Cited by 1,783 · see citing works
Synaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715 · see citing works
Hayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R. (2000) · Science · doi:10.1126/science.287.5461.2262 · Cited by 1,524 · see citing works
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344 · see citing works
Variability, compensation and homeostasis in neuron and network function
Marder, E., & Goaillard, J.-M. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1949 · Cited by 1,212 · see citing works
Huang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., & Tonegawa, S. (1999) · Cell · doi:10.1016/s0092-8674(00)81509-3 · Cited by 1,198 · see citing works
AMPA receptor trafficking at excitatory synapses
Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150 · see citing works
Shi, S.-H., Hayashi, Y., Esteban, J. A., & Malinow, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00321-x · Cited by 1,094 · see citing works
Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α
Stellwagen, D., Beattie, E. C., Seo, J. Y., & Malenka, R. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4486-04.2005 · Cited by 985 · see citing works
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977 · see citing works
BDNF and Activity-Dependent Synaptic Modulation: Figure 1.
Lu, B. (2003) · Learning & Memory · doi:10.1101/lm.54603 · Cited by 945 · see citing works
The other side of the engram: experience-driven changes in neuronal intrinsic excitability
Zhang, W., & Linden, D. J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1248 · Cited by 866 · see citing works
Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons
Wenthold, R., Petralia, R., Blahos J, II, & Niedzielski, A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-01982.1996 · Cited by 850 · see citing works
Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.024 · Cited by 827 · see citing works
Homeostatic plasticity in neuronal networks: the more things change, the more they stay the same
Turrigiano, G. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01341-1 · Cited by 823 · see citing works
Self-citationThe role of the GluR2 subunit in AMPA receptor function and synaptic plasticity
Isaac, J. T. R., Ashby, M. C., & McBain, C. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.001 · Cited by 802 · see citing works
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792 · see citing works
Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors
Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.034 · Cited by 779 · see citing works
Impulse activity and the patterning of connections during cns development
Shatz, C. J. (1990) · Neuron · doi:10.1016/0896-6273(90)90333-b · Cited by 766 · see citing works
Stable Hebbian Learning from Spike Timing-Dependent Plasticity
van Rossum, M. C. W., Bi, G., & Turrigiano, G. G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08812.2000 · Cited by 724 · see citing works
Self-citationActivity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
O’Brien, R. J., Kamboj, S., Ehlers, M. D., Rosen, K. R., Fischbach, G. D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80624-8 · Cited by 688 · see citing works
Sutton, M. A., Ito, H. T., Cressy, P., Kempf, C., Woo, J. C., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.03.040 · Cited by 633 · see citing works
Inactivity produces increases in neurotransmitter release and synapse size
Murthy, V. N., Schikorski, T., Stevens, C. F., & Zhu, Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00500-1 · Cited by 612 · see citing works
Critical periods for experience-dependent synaptic scaling in visual cortex
Desai, N. S., Cudmore, R. H., Nelson, S. B., & Turrigiano, G. G. (2002) · Nature Neuroscience · doi:10.1038/nn878 · Cited by 582 · see citing works
Self-citationHOMEOSTATIC CONTROL OF NEURAL ACTIVITY: From Phenomenology to Molecular Design
Davis, G. W. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135751 · Cited by 543 · see citing works
Plant, K., Pelkey, K. A., Bortolotto, Z. A., Morita, D., Terashima, A., McBain, C. J., Collingridge, G. L., & Isaac, J. T. R. (2006) · Nature Neuroscience · doi:10.1038/nn1678 · Cited by 542 · see citing works
Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
Ju, W. H., Morishita, W., Tsui, J., Gaietta, G. M., Deerinck, T. J., Adams, S., Garner, C. C., Tsien, R. Y., Ellisman, M. H., & Malenka, R. C. (2004) · Nature Neuroscience · doi:10.1038/nn1189 · Cited by 524 · see citing works
The Ca2+–calmodulin-dependent protein kinase cascade
Soderling, T. R. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01383-3 · Cited by 509 · see citing works
Mechanism of TrkB-Mediated Hippocampal Long-Term Potentiation
Minichiello, L., Calella, A. M., Medina, D. L., Bonhoeffer, T., Klein, R., & Korte, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00942-x · Cited by 506 · see citing works
Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons
Rao, A., & Craig, A. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80962-9 · Cited by 492 · see citing works
Burrone, J., O'Byrne, M., & Murthy, V. N. (2002) · Nature · doi:10.1038/nature01242 · Cited by 487 · see citing works
Adaptation to Synaptic Inactivity in Hippocampal Neurons
Thiagarajan, T. C., Lindskog, M., & Tsien, R. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.037 · Cited by 482 · see citing works
Microglial control of neuronal death and synaptic properties
Bessis, A., Béchade, C., Bernard, D., & Roumier, A. (2006) · Glia · doi:10.1002/glia.20459 · Cited by 454 · see citing works
Rutherford, L. C., Nelson, S. B., & Turrigiano, G. G. (1998) · Neuron · doi:10.1016/s0896-6273(00)80563-2 · Cited by 451 · see citing works
Self-citationThe Role of Constraints in Hebbian Learning
Miller, K. D., & MacKay, D. J. C. (1994) · Neural Computation · doi:10.1162/neco.1994.6.1.100 · Cited by 448 · see citing works
Rapid Synaptic Scaling Induced by Changes in Postsynaptic Firing
Ibata, K., Sun, Q., & Turrigiano, G. G. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.031 · Cited by 446 · see citing works
Self-citationSelective reconfiguration of layer 4 visual cortical circuitry by visual deprivation
Maffei, A., Nelson, S. B., & Turrigiano, G. G. (2004) · Nature Neuroscience · doi:10.1038/nn1351 · Cited by 415 · see citing works
Self-citationKaneko, M., Stellwagen, D., Malenka, R. C., & Stryker, M. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.023 · Cited by 405 · see citing works
Verde, E. R., Lee‐Osbourne, J., Worley, P. F., Malinow, R., & Cline, H. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.031 · Cited by 403 · see citing works
Rutherford, L. C., DeWan, A., Lauer, H. M., & Turrigiano, G. G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04527.1997 · Cited by 381 · see citing works
Self-citationKilman, V., van Rossum, M. C. W., & Turrigiano, G. G. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01328.2002 · Cited by 362 · see citing works
Self-citationA Developmental Switch of AMPA Receptor Subunits in Neocortical Pyramidal Neurons
Kumar, S. S., Bacci, A., Kharazia, V., & Huguenard, J. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03005.2002 · Cited by 359 · see citing works
Glutamate receptor dynamics in dendritic microdomains.
Newpher, T. M., & Ehlers, M. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.030 · Cited by 356 · see citing works
Activity Coregulates Quantal AMPA and NMDA Currents at Neocortical Synapses
Watt, A. J., van Rossum, M. C. W., MacLeod, K. M., Nelson, S. B., & Turrigiano, G. G. (2000) · Neuron · doi:10.1016/s0896-6273(00)81202-7 · Cited by 350 · see citing works
Self-citationLissin, D., Gomperts, S. N., Carroll, R. C., Christine, C. W., Kalman, D., Kitamura, M., Hardy, S. F., Nicoll, R. A., Malenka, R. C., & von Zastrow, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7097 · Cited by 332 · see citing works
Homeostatic Regulation of Eye-Specific Responses in Visual Cortex during Ocular Dominance Plasticity
Mrsic-Flogel, T. D., Hofer, S. B., Ohki, K., Reid, R. C., Bonhoeffer, T., & Hübener, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.028 · Cited by 330 · see citing works
Activity-dependent regulation of conductances in model neurons
LeMasson, G., Marder, E., & Abbott, L. F. (1993) · Science · doi:10.1126/science.8456317 · Cited by 323 · see citing works
Regulation of CNS synapses by neuronal MHC class I
Goddard, C. A., Butts, D. A., & Shatz, C. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702023104 · Cited by 322 · see citing works
Synaptic Economics: Competition and Cooperation in Synaptic Plasticity
Miller, K. D. (1996) · Neuron · doi:10.1016/s0896-6273(00)80169-5 · Cited by 307 · see citing works
Postsynaptic expression of homeostatic plasticity at neocortical synapses
Wierenga, C. J., Ibata, K., & Turrigiano, G. G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5217-04.2005 · Cited by 306 · see citing works
Self-citationMaintaining the Stability of Neural Function: A Homeostatic Hypothesis
Davis, G. W., & Bezprozvanny, I. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.847 · Cited by 302 · see citing works
Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity
Ehlers, M. D., Heine, M., Groc, L., Lee, M.-C., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.010 · Cited by 300 · see citing works
Thiagarajan, T. C., Piedras-Renterı́a, E. S., & Tsien, R. W. (2002) · Neuron · doi:10.1016/s0896-6273(02)01049-8 · Cited by 288 · see citing works
Multiple Modes of Network Homeostasis in Visual Cortical Layer 2/3
Maffei, A., & Turrigiano, G. G. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5298-07.2008 · Cited by 282 · see citing works
Self-citationSutton, M. A., Taylor, A. M., Ito, H. T., Pham, A., & Schuman, E. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.030 · Cited by 274 · see citing works
Goel, A., & Lee, H.-K. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5038-06.2007 · Cited by 251 · see citing works
A Model Neuron with Activity-Dependent Conductances Regulated by Multiple Calcium Sensors
Liu, Z., Golowasch, J., Marder, E. E., & Abbott, L. F. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02309.1998 · Cited by 243 · see citing works
Activity-Dependent mRNA Splicing Controls ER Export and Synaptic Delivery of NMDA Receptors
Mu, Y., Otsuka, T., Horton, A. C., Scott, D. B., & Ehlers, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00676-7 · Cited by 240 · see citing works
Seeburg, D. P., Feliú-Mójer, M. I., Gaiottino, J., Pak, D. T. S., & Sheng, M. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.021 · Cited by 230 · see citing works
Local Dendritic Activity Sets Release Probability at Hippocampal Synapses
Branco, T., Staras, K., Darcy, K. J., & Goda, Y. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.006 · Cited by 230 · see citing works
Monocular deprivation induces homosynaptic long-term depression in visual cortex
Rittenhouse, C. D., Shouval, H. Z., Paradiso, M. A., & Bear, M. F. (1999) · Nature · doi:10.1038/16922 · Cited by 228 · see citing works
Activity-Dependent Regulation of Synaptic AMPA Receptor Composition and Abundance by β3 Integrins
Cingolani, L. A., Thalhammer, A., Yu, L. M. Y., Catalano, M., Ramos, T., Colicos, M. A., & Goda, Y. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.011 · Cited by 223 · see citing works
Conservation of Glutamate Receptor 2-Containing AMPA Receptors during Long-Term Potentiation
Adesnik, H., & Nicoll, R. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0325-07.2007 · Cited by 213 · see citing works
Bolton, M. M., Pittman, A. J., & Lo, D. C. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03221.2000 · Cited by 201 · see citing works
Molecular determinants of AMPA receptor subunit assembly
Greger, I. H., Ziff, E. B., & Penn, A. C. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.005 · Cited by 194 · see citing works
De Gois, S., Schäfer, M. K.-H., Defamie, N., Chen, C., Ricci, A., Weihe, E., Varoqui, H., & Erickson, J. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5221-04.2005 · Cited by 192 · see citing works
AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc
Rao, V. R., Pintchovski, S. A., Chin, J., Peebles, C., Mitra, S. S., & Finkbeiner, S. M. (2006) · Nature Neuroscience · doi:10.1038/nn1708 · Cited by 188 · see citing works
Homeostatic regulation of AMPA receptor expression at single hippocampal synapses
Hou, Q., Zhang, D., Jarzylo, L., Huganir, R. L., & Man, H.-Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706447105 · Cited by 179 · see citing works
A proportional but slower NMDA potentiation follows AMPA potentiation in LTP
Watt, A., Sjöström, P., Häusser, M., Nelson, S., & Turrigiano, G. (2004) · Nature Neuroscience · doi:10.1038/nn1220 · Cited by 176 · see citing works
Self-citationTemporal Regulation of the Expression Locus of Homeostatic Plasticity
Wierenga, C. J., Walsh, M. F., & Turrigiano, G. G. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00107.2006 · Cited by 175 · see citing works
Self-citationHomeostatic plasticity in the CNS: synaptic and intrinsic forms
Desai, N. S. (2003) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2004.01.005 · Cited by 164 · see citing works
Postsynaptic Depolarization Scales Quantal Amplitude in Cortical Pyramidal Neurons
Leslie, K. R., Nelson, S. B., & Turrigiano, G. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-j0005.2001 · Cited by 128 · see citing works
Self-citationβ-Catenin regulates excitatory postsynaptic strength at hippocampal synapses
Okuda, T., Yu, L. M. Y., Cingolani, L. A., Kemler, R., & Goda, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702334104 · Cited by 127 · see citing works
Swanwick, C. C., Murthy, N. R., & Kapur, J. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.11.002 · Cited by 110 · see citing works
Li, B., Zhang, L., Gu, J., Amin, N. D., & Pant, H. C. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06055.2000 · Cited by 106 · see citing works
Local Effects of BDNF on Dendritic Growth
Horch, H. W. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.2.117 · Cited by 103 · see citing works
Activity-Dependent Remodeling of Presynaptic Inputs by Postsynaptic Expression of Activated CaMKII
Pratt, K. G., Watt, A. J., Griffith, L. C., Nelson, S. B., & Turrigiano, G. G. (2003) · Neuron · doi:10.1016/s0896-6273(03)00422-7 · Cited by 101 · see citing works
Self-citationLTP and adaptation to inactivity: Overlapping mechanisms and implications for metaplasticity
Thiagarajan, T. C., Lindskog, M., Malgaroli, A., & Tsien, R. W. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.030 · Cited by 99 · see citing works
Gray, E. E., Fink, A. E., Sariñana, J., Vissel, B., & O’Dell, T. J. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00473.2007 · Cited by 94 · see citing works
Multiple forms of long-term plasticity at unitary neocortical layer 5 synapses
Sjöström, P. J., Turrigiano, G. G., & Nelson, S. B. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.021 · Cited by 90 · see citing works
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Rabinowitch, I., & Segev, I. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.05.005 · Cited by 90 · see citing works
Developmental homeostasis of mouse retinocollicular synapses
Chandrasekaran, A. R., Shah, R. D., & Crair, M. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4383-06.2007 · Cited by 90 · see citing works
Erickson, J. D., De Gois, S., Varoqui, H., Schafer, M. K.-H., & Weihe, E. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.029 · Cited by 89 · see citing works
Kirov, S. A., Goddard, C. A., & Harris, K. M. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.039 · Cited by 87 · see citing works
Current Compensation in Neuronal Homeostasis
Marder, E., & Prinz, A. A. (2003) · Neuron · doi:10.1016/s0896-6273(02)01173-x · Cited by 80 · see citing works
Harms, K. J., & Craig, A. M. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20635 · Cited by 79 · see citing works
BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth
Spencer, T. K., Mellado, W., & Filbin, M. T. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.02.005 · Cited by 58 · see citing works
Tokuoka, H., & Goda, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805705105 · Cited by 54 · see citing works
Lobo, F. M., Zanjani, R., Ho, N. Y., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.4.2057 · Cited by 51 · see citing works
Homeostatic synaptic scaling in self-organizing maps
Sullivan, T. J., & de Sa, V. R. (2006) · Neural Networks · doi:10.1016/j.neunet.2006.05.006 · Cited by 47 · see citing works
More than a sidekick: glia and homeostatic synaptic plasticity
Turrigiano, G. G. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.08.002 · Cited by 39 · see citing works
Self-citationCopi, A., Jüngling, K., & Gottmann, K. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00155.2005 · Cited by 25 · see citing works
Flagged first, then by citations
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y. S., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.013 · Cited by 2,072 · see citing works
Plasticity during stroke recovery: from synapse to behaviour
Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938 · see citing works
Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function
Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139 · see citing works
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Huganir, R. L., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.025 · Cited by 968 · see citing works
The many faces of insulin-like peptide signalling in the brain
Fernandez, A. M., & Torres-Alemán, I. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3209 · Cited by 872 · see citing works
The AMPA Receptor Code of Synaptic Plasticity
Diering, G. H., & Huganir, R. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.018 · Cited by 844 · see citing works
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
Jo, S., Yarishkin, O., Hwang, Y. J., Chun, Y. E., Park, M., Woo, D. H., Bae, J. Y., Kim, T., Lee, J., Chun, H., et al. (2014) · Nature Medicine · doi:10.1038/nm.3639 · Cited by 783 · see citing works
Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement
Turrigiano, G. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153238 · Cited by 671 · see citing works
Self-citationStructure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686 · see citing works
Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation
Moda-Sava, R. N., Murdock, M. H., Parekh, P. K., Fetcho, R. N., Huang, B. S., Huynh, T. N., Witztum, J., Shaver, D. C., Rosenthal, D. L., Alway, E. J., et al. (2019) · Science · doi:10.1126/science.aat8078 · Cited by 643 · see citing works
The Postsynaptic Organization of Synapses
Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603 · see citing works
Unraveling mechanisms of homeostatic synaptic plasticity
Pozo, K., & Goda, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.028 · Cited by 565 · see citing works
The “quad‐partite” synapse: Microglia‐synapse interactions in the developing and mature CNS
Schafer, D. P., Lehrman, E. K., & Stevens, B. (2013) · Glia · doi:10.1002/glia.22389 · Cited by 570 · see citing works
Homer1a drives homeostatic scaling-down of excitatory synapses during sleep
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Immune proteins in brain development and synaptic plasticity
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Plasticity of Cortical Excitatory-Inhibitory Balance
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Central gain control in tinnitus and hyperacusis
Auerbach, B. D., Rodrigues, P. V., & Salvi, R. J. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00206 · Cited by 439 · see citing works
Bramham, C. R., Alme, M. N., Bittins, M., Kuipers, S. D., Nair, R. R., Pai, B., Panja, D., Schubert, M., Soule, J., Tiron, A., et al. (2010) · Experimental Brain Research · doi:10.1007/s00221-009-1959-2 · Cited by 452 · see citing works
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Danese, A., & J Lewis, S. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.198 · Cited by 393 · see citing works
Different Neuronal Activity Patterns Induce Different Gene Expression Programs
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Pannasch, U., Vargová, L., Reingruber, J., Ezan, P., Holcman, D., Giaume, C., Syková, E., & Rouach, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016650108 · Cited by 383 · see citing works
Herculano-Houzel, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017514 · Cited by 343 · see citing works
Gangoda, L., Boukouris, S., Liem, M., Kalra, H., & Mathivanan, S. (2015) · PROTEOMICS · doi:10.1002/pmic.201400234 · Cited by 301 · see citing works
Okamoto, H., Stracke, H., Stoll, W., & Pantev, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911268107 · Cited by 311 · see citing works
Marder, E., O'Leary, T., & Shruti, S. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-013958 · Cited by 262 · see citing works
AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine
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Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects
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The molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works
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Zenke, F., Gerstner, W., & Ganguli, S. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.015 · Cited by 201 · see citing works
Garay, P. (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00136 · Cited by 217 · see citing works
Early Alzheimer’s disease pathology in human cortex involves transient cell states
Gazestani, V., Kamath, T., Nadaf, N. M., Dougalis, A., Burris, S. J., Rooney, B., Junkkari, A., Vanderburg, C., Pelkonen, A., Gomez-Budia, M., et al. (2023) · Cell · doi:10.1016/j.cell.2023.08.005 · Cited by 209 · see citing works
The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidation
Finnie, P. S. B., & Nader, K. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.03.008 · Cited by 189 · see citing works
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Sleep, its regulation and possible mechanisms of sleep disturbances
Porkka‐Heiskanen, T., Zitting, K. ‐., & Wigren, H. ‐. (2013) · Acta Physiologica · doi:10.1111/apha.12134 · Cited by 157 · see citing works
Pfeiffer, B. E., Zang, T., Wilkerson, J. R., Taniguchi, M., Maksimova, M. A., Smith, L. N., Cowan, C. W., & Huber, K. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.017 · Cited by 153 · see citing works
Deep sleep maintains learning efficiency of the human brain
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Kim, J., & Alger, B. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2517 · Cited by 149 · see citing works
GluA2-lacking, calcium-permeable AMPA receptors--inducers of plasticity?
Man, H.-Y. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.01.001 · Cited by 142 · see citing works
A review of hyperacusis and future directions: part II. Measurement, mechanisms, and treatment
Pienkowski, M., Tyler, R. S., Roncancio, E. R., Jun, H. J., Brozoski, T., Dauman, N., Coelho, C. B., Andersson, G., Keiner, A. J., Cacace, A. T., et al. (2014) · American Journal of Audiology · doi:10.1044/2014_aja-13-0037 · Cited by 138 · see citing works
Environmental enrichment and the sensory brain: The role of enrichment in remediating brain injury
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Shin, S. M., Zhang, N., Hansen, J., Gerges, N. Z., Pak, D. T. S., Sheng, M., & Lee, S. H. (2012) · Nature Neuroscience · doi:10.1038/nn.3259 · Cited by 126 · see citing works
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Krueger, J. M., Clinton, J. M., Winters, B. D., Zielinski, M. R., Taishi, P., Jewett, K. A., & Davis, C. J. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00003-x · Cited by 126 · see citing works
Nicoll, R. A., & Schulman, H. (2023) · Physiological Reviews · doi:10.1152/physrev.00034.2022 · Cited by 126 · see citing works
“The third mechanism, homeostasis, occurs on a slower timescale of many hours or days (368).”
BackgroundWagnon, J. L., Briese, M., Sun, W., Mahaffey, C. L., Curk, T., Rot, G., Ule, J., & Frankel, W. N. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003067 · Cited by 125 · see citing works
Frank, C. L., & Tsai, L.-H. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.029 · Cited by 118 · see citing works
Yang, R., Walder-Christensen, K. K., Kim, N., Wu, D., Lorenzo, D. N., Badea, A., Jiang, Y.-H., Yin, H. H., Wetsel, W. C., & Bennett, V. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1904348116 · Cited by 99 · see citing works
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Meadows, J. P., Guzman-Karlsson, M. C., Phillips, S., Holleman, C., Posey, J. L., Day, J. J., Hablitz, J. J., & Sweatt, J. D. (2015) · Science Signaling · doi:10.1126/scisignal.aab0715 · Cited by 111 · see citing works
Neuroimmune regulation of homeostatic synaptic plasticity
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Joseph, A., & Turrigiano, G. G. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0618-17.2017 · Cited by 94 · see citing works
Self-citationHeise, C., Gardoni, F., Culotta, L., di Luca, M., Verpelli, C., & Sala, C. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00035 · Cited by 99 · see citing works
Keck, T., Hübener, M., & Bonhoeffer, T. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.02.003 · Cited by 93 · see citing works
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Lee, H.-K., & Kirkwood, A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00520 · Cited by 101 · see citing works
Approaches and Limitations in the Investigation of Synaptic Transmission and Plasticity
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Francis, T. C., Chandra, R., Gaynor, A., Konkalmatt, P., Metzbower, S. R., Evans, B., Engeln, M., Blanpied, T. A., & Lobo, M. K. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.178 · Cited by 89 · see citing works
Ramasubbu, R., Clark, D. L., Golding, S., Dobson, K. S., Mackie, A., Haffenden, A., & Kiss, Z. H. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30415-8 · Cited by 80 · see citing works
Goforth, P. B., Ren, J., Schwartz, B. S., & Satin, L. S. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00467.2010 · Cited by 69 · see citing works
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Sciaccaluga, M., Megaro, A., Bellomo, G., Ruffolo, G., Romoli, M., Palma, E., & Costa, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115991 · Cited by 70 · see citing works
GRIP1 is required for homeostatic regulation of AMPAR trafficking
Tan, H. L., Queenan, B. N., & Huganir, R. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512786112 · Cited by 69 · see citing works
Fuller, O. K., Whitham, M., Mathivanan, S., & Febbraio, M. A. (2020) · Cells · doi:10.3390/cells9102182 · Cited by 60 · see citing works
Sokolova, I. V., Schneider, C. J., Bezaire, M., Soltesz, I., Vlkolinsky, R., & Nelson, G. A. (2015) · Radiation Research · doi:10.1667/rr13785.1 · Cited by 62 · see citing works
Francis, T. C., Gaynor, A., Chandra, R., Fox, M. E., & Lobo, M. K. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.007 · Cited by 61 · see citing works
Hyperexcitability and homeostasis in fragile X Syndrome.
Liu, X., Kumar, V., Tsai, N.-P., & Auerbach, B. D. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.805929 · Cited by 53 · see citing works
Homeostatic regulation of glutamatergic transmission by dopamine D <sub>4</sub> receptors
Yuen, E. Y., Zhong, P., & Yan, Z. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010025108 · Cited by 54 · see citing works
Suzuki, K., Kim, J.-W., Nosyreva, E., Kavalali, E. T., & Monteggia, L. M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109918 · Cited by 49 · see citing works
Garcia-Oscos, F., Peña, D., Housini, M., Cheng, D., Lopez, D., Borland, M. S., Salgado-Delgado, R., Salgado, H., D’Mello, S., Kilgard, M. P., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.07.020 · Cited by 43 · see citing works
Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material
Ryglewski, S., Vonhoff, F., Scheckel, K., & Duch, C. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.043 · Cited by 30 · see citing works
Miyamoto, T., Kim, D., Knox, J. A., Johnson, E., & Mucke, L. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.666529 · Cited by 33 · see citing works
Microglia: Activity‐dependent regulators of neural circuits
Durán Laforet, V., & Schafer, D. P. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15105 · Cited by 32 · see citing works
“81 82-85 It was further shown that seizures could be exacerbated by microglia-derived TNF α , and that blocking brain-derived TNF α reduced seizure severity.”
BackgroundGao, J., Marosi, M., Choi, J., Achiro, J. M., Kim, S., Li, S., Otis, K., Martin, K. C., Portera-Cailliau, C., & Tontonoz, P. (2017) · eLife · doi:10.7554/elife.29178 · Cited by 30 · see citing works
Synaptic memory survives molecular turnover
Lee, J., Chen, X., & Nicoll, R. A. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2211572119 · Cited by 27 · see citing works
Garcia-Bereguiain, M. A., Gonzalez-Islas, C., Lindsly, C., Butler, E., Hill, A. W., & Wenner, P. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4025-12.2013 · Cited by 26 · see citing works
BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex
Petrus, E., & Lee, H.-K. (2014) · Neural Plasticity · doi:10.1155/2014/128631 · Cited by 19 · see citing works
Koesters, A. G., Rich, M. M., & Engisch, K. L. (2024) · The Neuroscientist · doi:10.1177/10738584221112336 · Cited by 17 · see citing works
Karabanov, A., Ziemann, U., Hamada, M., George, M. S., Quartarone, A., Classen, J., Massimini, M., Rothwell, J., & Siebner, H. R. (2015) · Brain Stimulation · doi:10.1016/j.brs.2015.06.016 · Cited by 5 · see citing works
- Authors
- Turrigiano, G. G.
- Affiliations
- Brandeis University (US)
- Corresponding author
- Turrigiano, Gina G.
- ORCID
- Turrigiano, Gina G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 135
- Issue
- 3
- Pages
- 422-435
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2834419
- OpenAlex
- W2047535883
- Cited by
- 1,533
- References
- 100
- Citations by year
- 2026: 65 · 2025: 107 · 2024: 66 · 2023: 71 · 2022: 69 · 2021: 114 · 2020: 82 · 2019: 96 · 2018: 75 · 2017: 99 · 2016: 73 · 2015: 85 · 2014: 93 · 2013: 116 · 2012: 96
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1786 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Goddard Space Flight Center
- National Eye Institute (EY14439, R01EY014439)
- National Institute of Neurological Disorders and Stroke (NS 36853, R56NS036853, R01NS036853)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- homeostatic synaptic scaling, excitatory synapses, synaptic plasticity, neuronal firing rate, glutamate receptor trafficking, synaptic homeostasis
- MeSH terms
- Animals, Brain, Homeostasis, Humans, Neuronal Plasticity, Neurons, Synapses
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