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Enhanced Endocannabinoid Signaling Elevates Neuronal Excitability in Fragile X Syndrome

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Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity

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FMRP regulates the transition from radial glial cells to intermediate progenitor cells during neocortical development.

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PresynapticFmr1Genotype Influences the Degree of Synaptic Connectivity in a Mosaic Mouse Model of Fragile X Syndrome

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Neural differentiation of fragile X human embryonic stem cells reveals abnormal patterns of development despite successful neurogenesis

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Fragile X syndrome due to a missense mutation

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Reference values for body proportions and body composition in adult women with Ullrich-Turner syndrome

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Expression of fragile X mental retardation protein in neurons and glia of the developing and adult mouse brain.

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Auditory change detection in fragile X syndrome males: A brain potential study

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Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase

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Characterization of FMR1 proteins isolated from different tissues

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GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in theFmr1Knockout Mouse Model of Fragile X Syndrome

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A Target Cell-Specific Role for Presynaptic Fmr1 in Regulating Glutamate Release onto Neocortical Fast-Spiking Inhibitory Neurons

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Current Compensation in Neuronal Homeostasis

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Increased Persistent Sodium Current Causes Neuronal Hyperexcitability in the Entorhinal Cortex of Fmr1 Knockout Mice

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Prepulse inhibition in fragile X syndrome: Feasibility, reliability, and implications for treatment

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Loss of Functional A-Type Potassium Channels in the Dendrites of CA1 Pyramidal Neurons from a Mouse Model of Fragile X Syndrome

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Impaired Critical Period Plasticity in Primary Auditory Cortex of Fragile X Model Mice

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Genetic upregulation of BK channel activity normalizes multiple synaptic and circuit defects in a mouse model of fragile X syndrome

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Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice

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Fragile X mental retardation protein is required for chemically‐induced long‐term potentiation of the hippocampus in adult mice

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Beyond controlling cell size: functional analyses of S6K in tumorigenesis

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Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder

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Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1

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Individually tailored dosage regimen of full-spectrum Cannabis extracts for autistic core and comorbid symptoms: a real-life report of multi-symptomatic benefits

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The role of aberrant neural oscillations in the hippocampal-medial prefrontal cortex circuit in neurodevelopmental and neurological disorders

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TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits

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Altered integration of excitatory inputs onto the basal dendrites of layer 5 pyramidal neurons in a mouse model of Fragile X syndrome

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Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome

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Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome

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Combined DiI and Antibody Labeling Reveals Complex Dysgenesis of Hippocampal Dendritic Spines in a Mouse Model of Fragile X Syndrome

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GABAB1 receptor knockdown in prefrontal cortex induces behavioral aberrations associated with autism spectrum disorder in mice

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Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function

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Astrocytes in fragile X syndrome

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Frontal cortex hyperactivation and gamma desynchrony in Fragile X syndrome: Correlates of auditory hypersensitivity

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Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome

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Calcium-Dependent Regulation of Neuronal Excitability Is Rescued in Fragile X Syndrome by a Tat-Conjugated N-Terminal Fragment of FMRP

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Retinoic acid regulation of homoeostatic synaptic plasticity and its relationship to cognitive disorders

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Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome

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FMRP regulation of aggrecan mRNA translation controls perineuronal net development

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Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism

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E2F4DN Transgenic Mice: A Tool for the Evaluation of E2F4 as a Therapeutic Target in Neuropathology and Brain Aging

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The effect of single-cell knockout of Fragile X Messenger Ribonucleoprotein on synaptic structural plasticity

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An emerging role of STriatal-Enriched protein tyrosine Phosphatase in hyperexcitability-associated brain disorders

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FMRP Controls Neuronal Architecture and Synaptic Content of NMDA Receptors in Cultured Hippocampal Neurons

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Aberrant hippocampal gamma oscillations in a mouse model of fragile X syndrome: insights from in vitro slice models

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Glycosphingolipids are linked to elevated neurotransmission and neurodegeneration in a Drosophila model of Niemann Pick type C

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A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1-/y mice

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Deep functional measurements of Fragile X syndrome human neurons reveal multiparametric electrophysiological disease phenotype

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Olfactory dysfunction and altered cortical excitability in the mouse model of Fragile X Syndrome

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Untitled work

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Mosaic H3K9me3 at BREACHes predicts synaptic gene expression associated with fragile X syndrome cognitive severityPreprint

Pham, K., Malachowski, T., Zhou, L., Kim, J. H., Chuanbin, S., & Phillips‐Cremins, J. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.19.644148 · Cited by 2 · see citing works

Chloride imbalance in Fragile X syndrome

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Partners in plasticity: serotonergic glial interactions in brain circuit remodeling

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Impaired behavioral inhibition in Fmr1 KO mice is linked to disrupted visual cortex theta oscillations

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Impairment in the homeostatic recruitment of layer 5/6 neurons following whisker stimulation in Fmr1 KO mice

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Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autismPreprint

Bridi, M., Luo, N., Kim, G., O’Ferrall, C., Patel, R. V., Bertrand, S. J., Kannan, S., & Kirkwood, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.05.451213 · Cited by 1 · see citing works

Combined DiI and antibody labeling reveals complex dysgenesis of hippocampal spine synapses in a mouse model of Fragile X SyndromePreprint

Speranza, L., Filiz, K. D., Goebel, S., Perrone-Capano, C., Pulcrano, S., Volpicelli, F., & Francesconi, A. (2022) · bioRxiv · doi:10.1101/2022.09.20.508741

Restoring Transient Connectivity During Development Improves Dysfunctions in Fragile X MicePreprint

Dumontier, D., Liebman, S. A., Le, V.-H., George, S., Valdemar, D., Aelst, L. V., & Pouchelon, G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.08.611918 · Cited by 1 · see citing works

Altered developmental profile of the cortical head-direction signal in a rat model of Fragile X SyndromePreprint

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Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndromePreprint

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THE ASSOCIATION BETWEEN EPILEPSY AND SYNAPTIC PLASTICITY: BIBLIOMETRICS RESEARCH AND VISUAL ANALYSIS USING CITESPACE

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Whisker deprivation triggers a distinct form of cortical homeostatic plasticity that is impaired in the Fmr1 KOPreprint

Lakhani, A., Huang, W., Rodgers, C. C., & Wenner, P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.23.614487

Improvement of Behavioral Deficits in a Mouse Model of Fragile X Syndrome by Restoring α7 nAChR Hypofunction Associated with Aberrant Ly6H ExpressionPreprint

Goebel, S., Cordova-Martinez, D., Verselis, V. K., & Francesconi, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.01.621616

A human electrophysiological biomarker of Fragile X Syndrome is shared in V1 of Fmr1 KO mice and caused by loss of FMRP in cortical excitatory neuronsPreprint

Kornfeld-Sylla, S. S., Gelegen, Ç., Norris, J. E., Chaloner, F. A., Lee, M., Khela, M., Heinrich, M. J., Finnie, P. S. B., Ethridge, L. E., Erickson, C. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.19.644144

Interaction between neuromuscular junction metabolic requirements in fragile X syndrome and glycogen storage disease models

Gurijala, A. R., Rushton, E., Leahy, S. N., Nelson, N., Tessier, C. R., & Broadie, K. S. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052183

Early developmental characterization of gap-induced prepulse inhibition and habituation in the Fragile X Syndrome mouse modelPreprint

Abdullah, A., Liu, X., Murari, K., Yan, J., & Cheng, N. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.13.682100

Sleep-modulated disinhibition enables replay for memory consolidation, accelerated by ripplesPreprint

Dutta, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.09.693276

Olfactory Deficits in Fragile X Syndrome

Kuruppath, P. (2026) · European Journal of Neuroscience · doi:10.1111/ejn.70357

Enhanced Ba 2+ -sensitive inward rectifying potassium conductance reduces intrinsic excitability of layer 2/3 pyramidal neurons in the primary auditory cortex of Fmr1 knockout micePreprint

Moreno, C., Riquelme, D., Rio, C. A. C.-D., & Leiva‐Salcedo, E. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.03.703439

Reversing Pathophysiology in Fragile X Syndrome Mice by Promoting PGC-1α and Mitochondrial FunctionsPreprint

Acharya, A., Kumar, V., Lee, K. Y., Babik, M. S., Goswami, G., Boateng, K. A., Cyphersmith, A., Rhodes, J. S., & Tsai, N. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.13.718178

Early Developmental Characterization of Gap-Induced Prepulse Inhibition and Habituation of Auditory Startle Response in a Fragile X Syndrome Mouse Model

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Extracellular Vesicle Communication in the Central Nervous System: Mechanisms, Disease States, and Therapeutic Opportunities

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Dysregulation of cAMP-PKA-mediated mechanisms disrupts basal synaptic function in the absence of presynaptic FMRPPreprint

Lecomte, S., de Mira, B. C., Grosjean, N., & Mulle, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.01.755951

Altered Neuronal and Circuit Excitability in Fragile X Syndrome

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Mechanisms Driving the Emergence of Neuronal Hyperexcitability in Fragile X Syndrome

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Disrupted inhibitory plasticity and homeostasis in Fragile X syndrome

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Molecular Mechanisms of Synaptic Dysregulation in Fragile X Syndrome and Autism Spectrum Disorders

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The injury rate in professional basketball

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