The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Regulation of phospholipase C γ isoforms in haematopoietic cells
Abstract
Phospholipase C gamma (PLCgamma) isoforms are critical for the generation of calcium signals in haematopoietic systems in response to the stimulation of immune receptors. PLCgamma is unique amongst phospholipases in that it is tightly regulated by the action of a number of tyrosine kinases. It is itself directly phosphorylated on a number of tyrosines and contains several domains through which it can interact with other signalling proteins and lipid products such as phosphatidylinositol 3,4,5-trisphosphate. Through this network of interactions, PLCgamma is activated and recruited to its substrate, phosphatidylinositol 4,5-bisphosphate, at the membrane. Both isoforms of PLCgamma, PLCgamma1 and PLCgamma2, are present in haematopoietic cells. The signalling cascade involved in the regulation of these two isoforms varies between cells, though the systems are similar for both PLCgamma1 and PLCgamma2. We will compare these cascades for both PLCgamma1 and PLCgamma2 and discuss possible reasons as to why one form of PLCgamma and not the other is required for signalling in specific haematopoietic cells, including T lymphocytes, B lymphocytes, platelets, and mast cells.
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“In these cells, PLCγ2, downstream of B-cell receptor and Fc receptor signalling, regulates calcium-dependent functions supporting immune and inflammatory responses [5, 28].”
From TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation (2021) · cites this paper as [28]
Citations
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Osteoimmunology: The conceptual framework unifying the immune and skeletal systems
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Metadata
- Authors
- Wilde, J. I., & Watson, S. P.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Wilde, Jonathan I
- ORCID
- Watson, Steve P
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 13
- Issue
- 10
- Pages
- 691-701
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W109267590
- Cited by
- 149
- References
- 138
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 9
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- British Heart Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- phospholipase C-gamma, PLCγ1, PLCγ2, hematopoietic cells, calcium signaling, tyrosine kinase regulation, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 4,5-bisphosphate, T cells, B cells, platelets, mast cells
- MeSH terms
- Animals, B-Lymphocytes, Blood Cells, Blood Platelets, Isoenzymes, Models, Biological, Type C Phospholipases, Protein-Tyrosine Kinases, T-Lymphocytes, Signal Transduction, Protein Structure, Tertiary, Protein Isoforms, Receptor Protein-Tyrosine Kinases, Macromolecular Substances, Mice, Phospholipase C gamma
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