Cited by 150Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancerProtein Tyrosine Phosphatases

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Regulation of phospholipase C γ isoforms in haematopoietic cells

Wilde, Jonathan I, Watson, Steve P·2001·Cellular Signalling

DOI 10.1016/s0898-6568(01)00191-7

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Abstract

Phospholipase C gamma (PLCgamma) isoforms are critical for the generation of calcium signals in haematopoietic systems in response to the stimulation of immune receptors. PLCgamma is unique amongst phospholipases in that it is tightly regulated by the action of a number of tyrosine kinases. It is itself directly phosphorylated on a number of tyrosines and contains several domains through which it can interact with other signalling proteins and lipid products such as phosphatidylinositol 3,4,5-trisphosphate. Through this network of interactions, PLCgamma is activated and recruited to its substrate, phosphatidylinositol 4,5-bisphosphate, at the membrane. Both isoforms of PLCgamma, PLCgamma1 and PLCgamma2, are present in haematopoietic cells. The signalling cascade involved in the regulation of these two isoforms varies between cells, though the systems are similar for both PLCgamma1 and PLCgamma2. We will compare these cascades for both PLCgamma1 and PLCgamma2 and discuss possible reasons as to why one form of PLCgamma and not the other is required for signalling in specific haematopoietic cells, including T lymphocytes, B lymphocytes, platelets, and mast cells.

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Authors: Wilde, J. I., & Watson, S. P.
Affiliations: University of Oxford (GB)
Corresponding author: Wilde, Jonathan I
ORCID: Watson, Steve P
Venue: Cellular Signalling
Publisher: Elsevier BV
Published: 2001-10
Volume: 13
Issue: 10
Pages: 691-701
ISSN: 0898-6568 (ISSN-L)
DOI: 10.1016/s0898-6568(01)00191-7
OpenAlex: W109267590
Cited by: 149
References: 138
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 9
FWCI: 2.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cellular Signalling (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
British Heart Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: phospholipase C-gamma, PLCγ1, PLCγ2, hematopoietic cells, calcium signaling, tyrosine kinase regulation, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 4,5-bisphosphate, T cells, B cells, platelets, mast cells
MeSH terms: Animals, B-Lymphocytes, Blood Cells, Blood Platelets, Isoenzymes, Models, Biological, Type C Phospholipases, Protein-Tyrosine Kinases, T-Lymphocytes, Signal Transduction, Protein Structure, Tertiary, Protein Isoforms, Receptor Protein-Tyrosine Kinases, Macromolecular Substances, Mice, Phospholipase C gamma

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Regulation of phospholipase C γ isoforms in haematopoietic cells

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