Differential effect of chronic nicotine treatment on nicotinic receptor numbers in various brain regions of mice
Abstract
Studies of smoking behavior in human twin pairs indicate that genetic factors may influence whether people do, or do not, smoke. Because the ability to develop tolerance to behavioral and physiological effects of nicotine may regulate nicotine intake, studies of potential genetic influences on tolerance development were carried out using inbred mouse strains that differ in initial (first dose) sensitivity to nicotine. Nicotine-sensitive strains such as the C57BL and DBA strains develop tolerance to nicotine following chronic intravenous infusion of lower doses of nicotine than are required to elicit tolerance to nicotine in the nicotine-resistant strains such as C3H and BUB. Chronic nicotine infusion results in a dose-related increase in binding of [3H]-nicotine to brain membranes in all strains. Differences in this effect were seen among brain regions as well as between the strains. A quantitative autoradiographic analysis of the effects of chronic nicotine infusion on DBA/2 mice, which develop marked tolerance to nicotine, clearly indicates that nicotine binding is affected to various degrees in various brain nuclei. These results are discussed in terms of genetic influences on tolerance development.
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Different brain regions and nAChR subtypes have different upregulation parameters.
“While this prediction is straightforward, testing it has been confounded by the observation that different brain regions and nAChR subtypes have different upregulation parameters (Collins et al., 1989; Mao et al., 2008; Perry et al., 2007) and a lack of understanding of which brain regions are critically involved in specific withdrawal symptoms.”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Collins et al., 1989
Cites
A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate
Katz, B., & Thesleff, S. (1957) · The Journal of Physiology · doi:10.1113/jphysiol.1957.sp005838 · Cited by 1,463 · see citing works
Clarke, P. B. S., Schwartz, R., Paul, S. M., Cb, P., & Pert, A. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-05-01307.1985 · Cited by 1,037 · see citing works
Benwell, M. E. M., Balfour, D. J. K., & Anderson, J. M. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb10600.x · Cited by 551 · see citing works
Nicotinic Cholinergic Receptor Binding Sites in the Brain: Regulation in Vivo
Schwartz, R. D., & Kellar, K. J. (1983) · Science · doi:10.1126/science.6828889 · Cited by 479 · see citing works
Boulter, J., Connolly, J. G., Deneris, E. S., Goldman, D. A., Heinemann, S. F., & Patrick, J. W. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7763 · Cited by 430 · see citing works
Goldman, D. J., Deneris, E. S., Luyten, W. H. M. L., Kochhar, A., Patrick, J., & Heinemann, S. (1987) · Cell · doi:10.1016/0092-8674(87)90705-7 · Cited by 388 · see citing works
Stereospecific Nicotine Receptors on Rat Brain Membranes
Romano, C., & D, A. G. M. (1980) · Science · doi:10.1126/science.7433991 · Cited by 318 · see citing works
Marks, M. J., & Collins, A. C. (1982) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)15183-3 · Cited by 310 · see citing works
Self-citationIn Vivo Regulation of [3H]Acetylcholine Recognition Sites in Brain by Nicotinic Cholinergic Drugs
Schwartz, R. D., & Kellar, K. J. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb04005.x · Cited by 282 · see citing works
Marks, M. J., Stitzel, J. A., Romm, E., Wehner, J. M., & Collins, A. C. (1986) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10395-7 · Cited by 267 · see citing works
Self-citationNicotinic cholinergic receptors labeled by [3H]acetylcholine in rat brain.
Schwartz, R. D., McGee, R., & Kellar, K. J. (1982) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)15102-x · Cited by 262 · see citing works
Ksir, C., Hakan, R., Hall, D. P., & Kellar, K. J. (1985) · Neuropharmacology · doi:10.1016/0028-3908(85)90058-9 · Cited by 204 · see citing works
Genetic influences on nicotine responses
Marks, M. J., Stitzel, J. A., & Collins, A. C. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90406-1 · Cited by 170 · see citing works
Self-citationSmoking, physiological arousal, and emotional response.
Nesbitt, P. D. (1973) · Journal of Personality and Social Psychology · doi:10.1037/h0034256 · Cited by 164 · see citing works
Fisher, R. A. (1958) · Nature · doi:10.1038/182596a0 · Cited by 163 · see citing works
Fisher, R. A. (1958) · Nature · doi:10.1038/182108a0 · Cited by 149 · see citing works
Mimnaugh, E. G., Gram, T. E., & Trush, M. A. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21829-8 · Cited by 140 · see citing works
Genetics of nicotine response in four inbred strains of mice
Marks, M. J., Burch, J. B., & Collins, A. C. (1983) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21452-5 · Cited by 140 · see citing works
Self-citationNeuronal nicotinic acetylcholine receptor β‐subunit is coded for by the cDNA clone α4
Whiting, P. J., Esch, F. S., Shimasaki, S., & Lindstrom, J. M. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80272-7 · Cited by 134 · see citing works
The binding of L-[3H]nicotine to a single class of high affinity sites in rat brain membranes.
Lippiello, P. M., & Fernandes, K. G. (1986) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10280-0 · Cited by 123 · see citing works
[3H]acetylcholine and [3H](-)nicotine label the same recognition site in rat brain.
Martino-Barrows, A. M., & Kellar, K. J. (1987) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10350-7 · Cited by 115 · see citing works
Goldman, D. J., Simmons, D. M., Swanson, L. W., Patrick, J., & Heinemann, S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4076 · Cited by 111 · see citing works
Wonnacott, S. (1987) · Human Toxicology · doi:10.1177/096032718700600502 · Cited by 93 · see citing works
Classical genetic analysis of nicotine-induced seizures and nicotinic receptors.
Miner, L. L., Marks, M. J., & Collins, A. C. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21686-x · Cited by 80 · see citing works
Self-citationDose-response analysis of nicotine tolerance and receptor changes in two inbred mouse strains.
Marks, M. J., Stitzel, J. A., & Collins, A. C. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23600-x · Cited by 80 · see citing works
Self-citationTolerance, cross-tolerance, and receptors after chronic nicotine or oxotremorine
Marks, M. J., & Collins, A. C. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90392-2 · Cited by 70 · see citing works
Self-citationSmoking Habits of Monozygotic and Dizygotic Twins
Friberg, L., Kaij, L., Dencker, S. J., et al. (1959) · BMJ · doi:10.1136/bmj.1.5129.1090 · Cited by 61 · see citing works
Crumpacker, D. W., Cederlöf, R., Friberg, L. T., et al. (1979) · Acta geneticae medicae et gemellologiae · doi:10.1017/s0001566000009041 · Cited by 59 · see citing works
Relationship between nicotine-induced seizures and hippocampal nicotinic receptors
Miner, L. L., Marks, M. J., & Collins, A. C. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90628-9 · Cited by 56 · see citing works
Self-citationGenetic analysis of nicotine-induced seizures and hippocampal nicotinic receptors in the mouse.
Miner, L. L., Marks, M. J., & Collins, A. C. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23376-6 · Cited by 52 · see citing works
Self-citationTwin similarity for usage of common drugs.
Pedersen, N. (1981) · PubMed · Cited by 52 · see citing works
Raaschou-Nielsen, E. (1960) · PubMed · Cited by 50 · see citing works
Effect of long-term nicotine treatment on [3H] nicotine binding sites in the rats brain
Nordberg, A. K., Wahlström, G., Arnelo, U., & Larsson, C. U. (1985) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(85)90077-8 · Cited by 47 · see citing works
Nicotine binding to brain tissue from drug-naive and nicotine-treated rats
Benwell, M. E. M., & Balfour, D. J. K. (1985) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1985.tb03024.x · Cited by 38 · see citing works
Alteration of nicotinic cholinergic agonist binding sites in hippocampus after fimbria transection
Morrow, A. L., Loy, R., & Creese, I. (1985) · Brain Research · doi:10.1016/0006-8993(85)90223-9 · Cited by 34 · see citing works
Regulation of the Nicotinic Acetylcholine Receptor by Protein Phosphorylation
Huganir, R. L. (1987) · Journal of Receptor Research · doi:10.3109/10799898709054988 · Cited by 31 · see citing works
Concordance of smoking habits in monozygotic and dizygotic twins
Todd, G. F., & Mason, J. I. (1959) · Heredity · doi:10.1038/hdy.1959.46 · Cited by 31 · see citing works
Larsson, C. U., Nilsson, L. M., Halén, A., & Nordberg, A. K. (1986) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(86)90034-7 · Cited by 30 · see citing works
Effect of nicotine pretreatment on nicotine-induced seizures
Miner, L. L., & Collins, A. C. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90171-2 · Cited by 24 · see citing works
Self-citationNadeau, G., & Joly, L. P. (1958) · Nature · doi:10.1038/182180a0 · Cited by 18 · see citing works
Individual differences in nicotine sensitivity
Jones, R. A. (1986) · Addictive Behaviors · doi:10.1016/0306-4603(86)90023-7 · Cited by 18 · see citing works
(1963) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1963.tb24810.x · Cited by 17 · see citing works
Personality and Smoking Patterns in a Twin Population
Dies, R. R., Honeyman, M. S., Reznikoff, M., et al. (1969) · Journal of Projective Techniques and Personality Assessment · doi:10.1080/0091651x.1969.10120616 · Cited by 14 · see citing works
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Effect of smoking history on [3H]nicotine binding in human postmortem brain
Breese, C. R., Marks, M. J., Logel, J., Adams, C. E., Sullivan, B., Collins, A. C., & Leonard, S. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36798-9 · Cited by 396 · see citing works
Self-citationMukhin, A. G., Kimes, A. S., Chefer, S. I., Matochik, J. A., Contoreggi, C. S., Horti, A. G., Vaupel, D. B., Pavlova, O., & Stein, E. A. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.050716 · Cited by 135 · see citing works
Temporal Change in Human Nicotinic Acetylcholine Receptor After Smoking Cessation: 5IA SPECT Study
Mamede, M., Ishizu, K., Ueda, M., Mukai, T., Iida, Y., Kawashima, H., Fukuyama, H., Togashi, K., & Saji, H. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.043471 · Cited by 90 · see citing works
Mugnaini, M., Tessari, M., Tarter, G., Merlo Pich, E., Chiamulera, C., & Bunnemann, B. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02220.x · Cited by 88 · see citing works
Nguyen, H. N., Rasmussen, B. A., & Perry, D. C. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02482.x · Cited by 83 · see citing works
Gould, T. J., Portugal, G. S., André, J. M., Tadman, M. P., Marks, M. J., Kenney, J. W., Yildirim, E., & Adoff, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.003 · Cited by 56 · see citing works
“While this prediction is straightforward, testing it has been confounded by the observation that different brain regions and nAChR subtypes have different upregulation parameters (Collins et al., 1989; Mao et al., 2008; Perry et al., 2007) and a lack of understanding of which brain regions are critically involved in s…”
Self-citationCommons, K. G. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.056 · Cited by 17 · see citing works
- Authors
- Collins, A. C., Marks, M. J., & Pauly, J. R.
- Corresponding author
- Collins, Allan C.
- ORCID
- Marks, Michael J.
- Venue
- Journal of Substance Abuse
- Publisher
- Elsevier BV
- Published
- 1989
- Volume
- 1
- Issue
- 3
- Pages
- 273-286
- ISSN
- 0899-3289 (ISSN-L)
- OpenAlex
- W2406721842
- Cited by
- 17
- References
- 44
- Citations by year
- 2018: 1 · 2015: 1 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Substance Abuse (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The National Institute on Drug Abuse (DA-03194)
- Dr. Collins is the recipient of a Research Scientist Development Award (DA-00116)
- National Institute on Drug Abuse and J.R. Pauly is a postdoctoral trainee supported, in part, by a training grant from The National Institute on Child Health and Human Development (HD-07289)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- chronic nicotine treatment, nicotinic acetylcholine receptors, nicotine tolerance, genetic susceptibility to smoking, inbred mouse strains, DBA/2 mice, C57BL mice, C3H mice, regional brain differences
- MeSH terms
- Animals, Arousal, Brain, Brain Mapping, Dose-Response Relationship, Drug, Drug Tolerance, Mice, Inbred Strains, Nicotine, Receptors, Nicotinic, Smoking, Species Specificity, Mice
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