Cited by 17Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeurotransmitter Receptor Influence on Behavior

Differential effect of chronic nicotine treatment on nicotinic receptor numbers in various brain regions of mice

Collins, Allan C., Marks, Michael J., Pauly, James R.·1989·Journal of Substance Abuse

Abstract

Studies of smoking behavior in human twin pairs indicate that genetic factors may influence whether people do, or do not, smoke. Because the ability to develop tolerance to behavioral and physiological effects of nicotine may regulate nicotine intake, studies of potential genetic influences on tolerance development were carried out using inbred mouse strains that differ in initial (first dose) sensitivity to nicotine. Nicotine-sensitive strains such as the C57BL and DBA strains develop tolerance to nicotine following chronic intravenous infusion of lower doses of nicotine than are required to elicit tolerance to nicotine in the nicotine-resistant strains such as C3H and BUB. Chronic nicotine infusion results in a dose-related increase in binding of [3H]-nicotine to brain membranes in all strains. Differences in this effect were seen among brain regions as well as between the strains. A quantitative autoradiographic analysis of the effects of chronic nicotine infusion on DBA/2 mice, which develop marked tolerance to nicotine, clearly indicates that nicotine binding is affected to various degrees in various brain nuclei. These results are discussed in terms of genetic influences on tolerance development.

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Crossref · 10.1016/s0899-3289(18)30004-x

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Authors
Collins, A. C., Marks, M. J., & Pauly, J. R.
Corresponding author
Collins, Allan C.
Venue
Journal of Substance Abuse
Publisher
Elsevier BV
Published
1989
Volume
1
Issue
3
Pages
273-286
ISSN
0899-3289 (ISSN-L)
OpenAlex
W2406721842
Cited by
17
References
44
Citations by year
2018: 1 · 2015: 1 · 2012: 2
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Substance Abuse (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • The National Institute on Drug Abuse (DA-03194)
  • Dr. Collins is the recipient of a Research Scientist Development Award (DA-00116)
  • National Institute on Drug Abuse and J.R. Pauly is a postdoctoral trainee supported, in part, by a training grant from The National Institute on Child Health and Human Development (HD-07289)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
chronic nicotine treatment, nicotinic acetylcholine receptors, nicotine tolerance, genetic susceptibility to smoking, inbred mouse strains, DBA/2 mice, C57BL mice, C3H mice, regional brain differences
MeSH terms
Animals, Arousal, Brain, Brain Mapping, Dose-Response Relationship, Drug, Drug Tolerance, Mice, Inbred Strains, Nicotine, Receptors, Nicotinic, Smoking, Species Specificity, Mice

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