Genetics of nicotine response in four inbred strains of mice
Abstract
The effects of nicotine on five behavioral and physiological measures were determined in four inbred mouse strains (BALB, C57BL, DBA and C3H). In addition, the binding characteristics of nicotine and alpha-bungarotoxin, two ligands which appear to label different nicotinic receptors, were measured in seven discrete brain regions, as well as in whole brain. A number of differences in response to nicotine were found among the four inbred strains. Whereas nicotine depressed open-field activity of BALB, C57BL and DBA mice in a dose-dependent manner, low doses of nicotine increased locomotor activity in C3H mice. The doses of nicotine tested reduced Rotarod performance in DBA and C57BL mice but not in C3H and BALB mice. All four strains displayed a dose-dependent decrease in body temperature after nicotine administration. The BALB mice were more sensitive to the drug than were the C3H, whereas the effects on C57BL and DBA mice were intermediate. All four strains showed a transient increase in respiration only after a high (2.0 mg/kg) nicotine dose. No dose of nicotine was found to have an effect on the startle response after auditory stimulation in three of the strains; only the C3H mice exhibited enhanced startle after nicotine was administered. Differences in DL-[ 3H ]nicotine binding among the seven brain regions were noted in each strain, but no differences among strains were observed. The IC50 values for inhibition of this binding by nicotine did not differ among brain regions within any strain or within any region among strains. Similarly, nicotine inhibited alpha-[125I]bungarotoxin binding with equal potency in all brain regions of each of the four strains; however, the binding of this ligand was significantly lower in the midbrain and hippocampus of DBA mice than it was in these regions in the other three strains. Thus, genetic factors influence response to nicotine, but variation in response is not easily explained by differences in brain nicotinic receptors.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Strain differences in the antidepressant effects of nicotinic agonists and antagonists have been identified, and strains of mice can show profoundly different behavioral responses to nicotine administration.
“Strain differences in the antidepressant effects of nicotinic agonists and antagonists have been identified (Andreasen and Redrobe, 2009) and strains of mice can show profoundly different behavioral responses to nicotine administration (Marks et al., 1983; Marks et al., 1986)”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Marks et al., 1983
Cited by
Sorted by citations
Guidelines on nicotine dose selection for in vivo research
Matta, S. G., Balfour, D. J., Benowitz, N. L., Boyd, R. T., Buccafusco, J. J., Caggiula, A. R., Craig, C. R., Collins, A. C., Damaj, M. I., Donny, E. C., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0441-0 · Cited by 824 · see citing works
Self-citationEffect of smoking history on [3H]nicotine binding in human postmortem brain
Breese, C. R., Marks, M. J., Logel, J., Adams, C. E., Sullivan, B., Collins, A. C., & Leonard, S. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36798-9 · Cited by 396 · see citing works
Self-citationGenetic Influence on Smoking — A Study of Male Twins
Carmelli, D., Swan, G. E., Robinette, D., & Fabsitz, R. R. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209173271201 · Cited by 328 · see citing works
Hippocampal protein kinase C activity is reduced in poor spatial learners
Wehner, J. M., Sleight, S., & Upchurch, M. B. (1990) · Brain Research · doi:10.1016/0006-8993(90)91485-y · Cited by 223 · see citing works
Young, J. W., Finlayson, K., Spratt, C., Marston, H. M., Crawford, N., Kelly, J. S., & Sharkey, J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300393 · Cited by 219 · see citing works
“Further increases in nicotine dose have been shown to lead to motoric inhibition and hypothermia (Marks et al, 1983; Figure 5).”
BackgroundHeath, A. C., & Martin, N. G. (1993) · Addictive Behaviors · doi:10.1016/0306-4603(93)90005-t · Cited by 209 · see citing works
Genetic influences on nicotine responses
Marks, M. J., Stitzel, J. A., & Collins, A. C. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90406-1 · Cited by 170 · see citing works
Self-citationPicciotto, M. R., Lewis, A. S., van Schalkwyk, G. I., & Mineur, Y. S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.028 · Cited by 157 · see citing works
Behavior and mutagenesis screens: The importance of baseline analysis of inbred strains
Tarantino, L. M., Gould, T. J., Druhan, J. P., & Bucan, M. (2000) · Mammalian Genome · doi:10.1007/s003350010107 · Cited by 158 · see citing works
“…been used extensively as an indicator of ataxic effects for both genetically altered mice (Brandon et al. 1998; Rubinstein et al. 1997) and in response to a variety of substances including ethanol (Schafer and Crabbe 1996), benzodiazepines (Stinchcomb et al. 1989), and nicotine (Marks et al. 1983).”
BackgroundGenetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction
Mineur, Y. S., & Picciotto, M. R. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.010 · Cited by 138 · see citing works
“Comprehensive batteries of behavioral tests have been used to further define the effects of nicotine across a large number of inbred strains [75], and have shown that response to nicotine cannot simply be explained by nAChR levels in the brain [76].”
BackgroundCholinotoxic Effects of Aluminum in Rat Brain
Gulya, K., Rakonczay, Z., & Kása, P. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02352.x · Cited by 124 · see citing works
Effects of Nicotine and Stress on Startle Amplitude and Sensory Gating Depend on Rat Strain and Sex
Faraday, M. M., O’Donoghue, V. A., & Grunberg, N. E. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00159-2 · Cited by 115 · see citing works
Genetics of smoking: A brief review
Hughes, J. R. (1986) · Behavior Therapy · doi:10.1016/s0005-7894(86)80066-1 · Cited by 110 · see citing works
Postnatal Development of Cholinergic Enzymes and Receptors in Mouse Brain
Fiedler, E. P., Marks, M. J., & Collins, A. C. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb00990.x · Cited by 101 · see citing works
Self-citationVariation of nicotinic binding sites among inbred strains
Marks, M. J., Romm, E., Campbell, S. M., & Collins, A. C. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90407-3 · Cited by 99 · see citing works
Self-citationWonnacott, S. (1987) · Human Toxicology · doi:10.1177/096032718700600502 · Cited by 93 · see citing works
Monoamine Oxidase Inhibitors Allow Locomotor and Rewarding Responses to Nicotine
Villégier, A., Salomon, L., Granon, S., Changeux, J., Belluzzi, J. D., Leslie, F. M., & Tassin, J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300987 · Cited by 91 · see citing works
“…both in rats and mice, nicotine is a weak locomotor stimulant in rats and generally fails to induce locomotor hyperactivity in mice at any dose (Marks et al, 1983; Freeman et al, 1987; Kita et al, 1988; Damaj and Martin, 1993; Smolen et al, 1994; Itzhak and Martin, 1999; Sparks and Pauly,…”
Tassin, J. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.038 · Cited by 91 · see citing works
Temporal Change in Human Nicotinic Acetylcholine Receptor After Smoking Cessation: 5IA SPECT Study
Mamede, M., Ishizu, K., Ueda, M., Mukai, T., Iida, Y., Kawashima, H., Fukuyama, H., Togashi, K., & Saji, H. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.043471 · Cited by 90 · see citing works
“The increase in nicotinic receptor number and the decreased rate of receptor turnover may be related to nicotinic receptor channel desensitization, which appears to reflect the conformational state of the receptor channel (21,22).”
BackgroundGenetic and Social Determinants of Initiation and Age at Onset of Smoking in Australian Twins
Heath, A. C., Kirk, K. M., Meyer, J. M., & Martin, N. G. (1999) · Behavior Genetics · doi:10.1023/a:1021670703806 · Cited by 87 · see citing works
Nguyen, H. N., Rasmussen, B. A., & Perry, D. C. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02482.x · Cited by 83 · see citing works
Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5
Siu, E. C. K., Wildenauer, D. B., & Tyndale, R. F. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0306-6 · Cited by 82 · see citing works
“In inbred mice, there are marked differences in response to nicotine across strains (Collins et al. 1988; Crawley et al. 1997; Marks et al. 1983).”
BackgroundGould, T. J., & Lommock, J. A. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.6.1276 · Cited by 79 · see citing works
Genetic and pharmacological models of cholinergic supersensitivity and affective disorders
Overstreet, D. H., Russell, R. W., Crocker, A. D., Gillin, J. C., & Janowsky, D. S. (1988) · Cellular and Molecular Life Sciences · doi:10.1007/bf01958920 · Cited by 78 · see citing works
Electronic cigarette exposure disrupts blood-brain barrier integrity and promotes neuroinflammation
Heldt, N. A., Seliga, A., Winfield, M., Gajghate, S., Reichenbach, N. L., Yu, X., Rom, S., Tenneti, A., May, D., Gregory, B. D., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.03.034 · Cited by 77 · see citing works
“Finally, open field provided additional assurance that acute nicotinic motor stimulation (Marks et al., 1983) was not a confounder.”
BackgroundVillégier, A. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00223-5 · Cited by 75 · see citing works
“For example, although psychostimulants and opiates induce locomotor hyperactivity both in rats and mice, nicotine generally fails to do so in mice (Marks et al., 1983).”
Background[3H](-)nicotine binding sites in fetal human brain
Cairns, N. J., & Wonnacott, S. (1988) · Brain Research · doi:10.1016/0006-8993(88)90192-8 · Cited by 73 · see citing works
Understanding the habenula: A major node in circuits regulating emotion and motivation
Ables, J. L., Park, K., & Ibáñez-Tallon, I. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106734 · Cited by 76 · see citing works
Prepulse startle deficit in the Brown Norway rat: A potential genetic model.
Palmer, A. A., Dulawa, S. C., Mottiwala, A. A., et al. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.2.374 · Cited by 73 · see citing works
Genetic influences on acute responses to nicotine and nicotine tolerance in the mouse
Collins, A. C., Miner, L. L., & Marks, M. J. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90455-8 · Cited by 73 · see citing works
Self-citationMecamylamine blockade of nicotine responses: Evidence for two brain nicotinic receptors
Collins, A. C., Evans, C. B., Miner, L. L., & Marks, M. J. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90518-6 · Cited by 67 · see citing works
Self-citationTolerance, cross-tolerance, and receptors after chronic nicotine or oxotremorine
Marks, M. J., & Collins, A. C. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90392-2 · Cited by 70 · see citing works
Self-citationRueter, L. E., Anderson, D. J., Briggs, C. A., Donnelly‐Roberts, D. L., Gintant, G. A., Gopalakrishnan, M., Lin, N., Osinski, M. A., Reinhart, G. A., Buckley, M. J., et al. (2004) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2004.tb00011.x · Cited by 70 · see citing works
Clark, W. G., & Lipton, J. M. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90023-5 · Cited by 68 · see citing works
Nicotine tolerance: an analysis of the time course of its development and loss in the rat
Collins, A. C., Romm, E., & Wehner, J. M. (1988) · Psychopharmacology · doi:10.1007/bf02431526 · Cited by 66 · see citing works
Self-citationA test battery for measuring nicotine effects in mice
Marks, M. J., Romm, E., Bealer, S. M., & Collins, A. C. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90577-5 · Cited by 65 · see citing works
Self-citationAddiction‐related neuroadaptations following chronic nicotine exposure
Wills, L., & Kenny, P. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15356 · Cited by 61 · see citing works
Nicotine and Hippocampus-Dependent Learning: Implications for Addiction
Gould, T. J. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:2:93 · Cited by 61 · see citing works
“The increases in nAChR binding sites may be a compensatory mechanism induced by nAChR desensitization (158,162).”
Facts about nicotine toxicity.
Karačonji, I. B. (2005) · PubMed · Cited by 61 · see citing works
Quantitative Genetics and Mouse Behavior
Wehner, J. M., Radcliffe, R. A., & Bowers, B. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.845 · Cited by 58 · see citing works
Mitochondrial metabolism during fasting-induced daily torpor in mice
Brown, J. C. L., & Staples, J. F. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.009 · Cited by 54 · see citing works
Relationship between nicotine-induced seizures and hippocampal nicotinic receptors
Miner, L. L., Marks, M. J., & Collins, A. C. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90628-9 · Cited by 56 · see citing works
Self-citationNicotine response and nicotinic receptors in long-sleep and short-sleep mice
de Fiebre, C. M., Medhurst, L. J., & Collins, A. C. (1987) · Alcohol · doi:10.1016/0741-8329(87)90092-9 · Cited by 55 · see citing works
Self-citationLichtman, A. H., Smith, F. L., & Martin, B. R. (1993) · Pain · doi:10.1016/0304-3959(93)90003-8 · Cited by 54 · see citing works
Genetic Influences on Tobacco Use: A Review of Human and Animal Studies
Collins, A. C. (1990) · International Journal of the Addictions · doi:10.3109/10826089009067004 · Cited by 52 · see citing works
Self-citationComparison of behavioral and central BDZ binding profile in three rat lines
Onaivi, E. S., Maguire, P. A., Tsai, N. F., et al. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90414-b · Cited by 50 · see citing works
Dose-Response Features of Neuroprotective Agents: An Integrative Summary
Calabrese, E. J. (2008) · Critical Reviews in Toxicology · doi:10.1080/10408440801981965 · Cited by 50 · see citing works
Evidence for modulation of GABAergic neurotransmission by nicotine
Freun, R. K., Jungschaffer, D. A., Collins, A. C., & Wehner, J. M. (1988) · Brain Research · doi:10.1016/0006-8993(88)90160-6 · Cited by 49 · see citing works
Self-citationMarty, M., Erwin, V., Cornell, K., & Zgombick, J. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90397-1 · Cited by 49 · see citing works
McCallum, S. E., Parameswaran, N., Bordia, T., Fan, H., McIntosh, J. M., & Quik, M. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.104414 · Cited by 48 · see citing works
“The 4 2* nAChR population is increased in rodent brain, with chronic nicotine treatment, and is also elevated in the brains of smokers (Marks et al., 1983; Schwartz and Kellar, 1983; Benwell et al., 1988).”
BackgroundMarubio, L. M., & Paylor, R. E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.003 · Cited by 45 · see citing works
Potential regulation of nicotine and ethanol actions by α4-containing nicotinic receptors
Tritto, T., Marley, R. J., Bastidas, D., Stitzel, J. A., & Collins, A. C. (2001) · Alcohol · doi:10.1016/s0741-8329(01)00135-5 · Cited by 43 · see citing works
Self-citationCharacterization of pharmacological and behavioral differences to nicotine in C57Bl/6 and DBA/2 mice
Jackson, K. J., Walters, C. L., Miles, M. F., Martin, B. R., & Damaj, M. I. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.020 · Cited by 41 · see citing works
“These tests revealed that while variations in nAChR expression and sensitivity contribute to nicotine responses, there are clearly additional genetic factors that contribute to the behavioral effects of nicotine (Marks et al., 1983).”
Tapper, A. R., McKinney, S. L., Marks, M. J., & Lester, H. A. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00063.2007 · Cited by 40 · see citing works
“3, A and B, which were back-crossed at least three generations (8).”
Self-citationGenetically determined differences in acute responses to diisopropylfluorophosphate
Smolen, A., Smolen, T. N., Wehner, J. M., et al. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90285-0 · Cited by 39 · see citing works
Self-citationGenetic and biological markers in drug abuse and alcoholism.
Braude, M. C., & Chao, H. (1986) · PubMed · Cited by 39 · see citing works
Effects of Cigarette Smoke in Mice Wound Healing is Strain Dependent
Cardoso, J. F., Romana‐Souza, B., Amadeu, T. P., Valença, S. S., Pôrto, L. C., & Monte‐Alto‐Costa, A. (2007) · Toxicologic Pathology · doi:10.1080/01926230701459986 · Cited by 38 · see citing works
“Studies, mainly involving behavioral aspects, showed that different strains respond in different ways to nicotine (Garg, 1969; Marks et al., 1983b), this fact has stimulated many studies about genotype influence on sensitivity to nicotine, the main component of cigarette smoke (Hatchell and…”
BackgroundDamaj, M. I., Siu, E. C. K., Sellers, E. M., Tyndale, R. F., & Martin, B. R. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111237 · Cited by 38 · see citing works
“Although nicotine induces locomotor hyperactivity in rats, it generally fails to induce locomotor hyperactivity in mice at any dose (Marks et al., 1983; Freeman et al., 1987; Kita et al., 1992; Damaj and Martin, 1993; Smolen et al., 1994; Itzhak and Martin, 1999; Castane et al., 2002; Gaddnas et…”
BackgroundMethodRauhut, A. S., Hawrylak, M., & MARDEKIAN, S. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.05.002 · Cited by 36 · see citing works
“Several studies have shown that mouse strains are differentially sensitive to the locomotoraltering effects of nicotine (Collins et al., 1988; Marks et al., 1983; Marks et al., 1989; Marks et al., 1991).”
Postnatal development of two nicotinic cholinergic receptors in seven mouse brain regions
Fiedler, E. P., Marks, M. J., & Collins, A. C. (1990) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(90)90045-4 · Cited by 37 · see citing works
Self-citationModulation of aggressive behavior in mice by nicotinic receptor subtypes
Lewis, A. S., Mineur, Y. S., Smith, P. H., Cahuzac, E. L. M., & Picciotto, M. R. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.019 · Cited by 36 · see citing works
“25 mg/kg) to solitary B6 mice predictably reduced locomotion in both home cage and sociability apparatus environments by ~30% [22], we found that the addition of a social “stimulus” mouse rescued this locomotor deficit, providing evidence that locomotor deficits cannot fully explain the serenic effect of nicotine in o…”
BackgroundKnott, V., Millar, A., Fisher, D. J., & Albert, P. R. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.053 · Cited by 34 · see citing works
Wilkinson, D. S., Turner, J. R., Blendy, J. A., & Gould, T. J. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2808-8 · Cited by 32 · see citing works
“Previous findings have shown that chronic nicotine upregulates nicotinic acetylcholine receptors (nAChRs) in the brain (Marks et al. 1983a; Schwartz and Kellar 1983), which return to control levels as the duration of withdrawal increases (Marks et al. 1985).”
InfluentialA genetic analysis of nicotine effects on open field activity
Marks, M. J., Miner, L. L., Cole-Harding, S., Burch, J. B., & Collins, A. C. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90584-8 · Cited by 31 · see citing works
Self-citationLewis, A. S., Pittenger, S. T., Mineur, Y. S., Stout, D., Smith, P. H., & Picciotto, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.276 · Cited by 32 · see citing works
Sack, R. A., Gochberg-Sarver, A., Rozovski, U., Kedmi, M., Rosner, S., & Orr‐Urtreger, A. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.02.032 · Cited by 31 · see citing works
A diallel analysis of nicotine-induced hypothermia
Marks, M. J., Miner, L. L., Burch, J. B., et al. (1984) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(84)80079-9 · Cited by 31 · see citing works
Self-citationPharmacological Aspects of Drug Dependence
Schuster, C. R., & Kuhar, M. J. (1996) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60963-3 · Cited by 31 · see citing works
Lanteri, C., Hernàndez-Vallejo, S. J., Salomon, L., Doucet, E. L., Godeheu, G., Torrens, Y., Houades, V., & Tassin, J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3315-08.2009 · Cited by 30 · see citing works
“For example, although psychostimulants and opiates induce a substantial locomotor hyperactivity both in rats and mice, nicotine is a weak locomotor stimulant in rats and fails to induce locomotor hyperactivity in mice with the exception of C3H strain (Marks et al., 1983; Kita et al., 1988; Smolen et al., 1994; Itzhak…”
BackgroundSmolen, A., Marks, M. J., DeFries, J. C., & Henderson, N. D. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90065-5 · Cited by 30 · see citing works
Self-citationGenetic differences in plasma corticosterone levels in response to nicotine injection
Freund, R. K., Martin, B. J., Jungschaffer, D. A., et al. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90139-6 · Cited by 30 · see citing works
Self-citationVariation in Nicotine Consumption in Inbred Mice Is Not Linked to Orosensory Ability
Glatt, A. R., Denton, K., & Boughter, J. D. (2008) · Chemical Senses · doi:10.1093/chemse/bjn049 · Cited by 29 · see citing works
Calabrese, E. J. (2008) · Critical Reviews in Toxicology · doi:10.1080/10408440802026315 · Cited by 29 · see citing works
“…both in rats and mice, nicotine is a weak locomotor stimulant in rats and generally fails to induce locomotor hyperactivity in mice at any dose (Marks et al., 1983; Freeman et al., 1987; Kita et al., 1988; Damaj and Martin, 1993; Smolen et al., 1994; Itzhak and Martin, 1999; Sparks and Pauly,…”
BackgroundInfluentialXu, J., Cohen, B. N., Zhu, Y., Dziewczapolski, G., Panda, S., Lester, H. A., Heinemann, S. F., & Contractor, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.78 · Cited by 29 · see citing works
“Nicotine administration affects motor skills in humans (69) and in rodent models (70).”
BackgroundYohn, N. L., Turner, J. R., & Blendy, J. A. (2014) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.211706 · Cited by 28 · see citing works
“…Marks et al., 1992; Buisson and Bertrand, 2002) and has been confirmed in several systems including cultured cells and rodent and human tissues (Marks et al., 1983; Schwartz and Kellar, 1985; Benwell et al., 1988; Peng et al., 1994; Breese et al., 1997; Perry et al., 1999; Staley et al., 2006).”
BackgroundNeurogenetic determinants and mechanisms of addiction to nicotine and smoked tobacco
Sharp, B. M., & Chen, H. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14171 · Cited by 28 · see citing works
“Pioneering studies from the laboratory of Collins and Marks (Marks et al., 1983, 1984; Miner & Collins, 1989) used multiple inbred mouse strains to ascertain the heritability of various nicotine-induced phenotypes (e.g., hypothermia, seizures, open field activity).”
BackgroundGenetic differences in nicotine-induced conditioned taste aversion
Risinger, F. O., & Brown, M. M. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00051-3 · Cited by 28 · see citing works
Differential sensitivity of long-sleep and short-sleep mice to high doses of cocaine
de Fiebre, C. M., Ruth, J. A., & Collins, A. C. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90289-x · Cited by 28 · see citing works
Self-citationDifferential effects of nicotine in inbred and selectively bred rodents
Overstreet, D. H. (1995) · Behavior Genetics · doi:10.1007/bf02196926 · Cited by 27 · see citing works
de Fiebre, C. M., & Collins, A. C. (1988) · Alcohol · doi:10.1016/0741-8329(88)90044-4 · Cited by 27 · see citing works
Self-citationde Fiebre, C. M., & Collins, A. C. (1989) · Alcohol · doi:10.1016/0741-8329(89)90072-4 · Cited by 27 · see citing works
Self-citationDARPP-32 Phosphorylation Opposes the Behavioral Effects of Nicotine
Zhu, H., Lee, M.-S., Guan, F., Agatsuma, S., Scott, D., Fabrizio, K., Fienberg, A. A., & Hiroi, N. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.026 · Cited by 24 · see citing works
Freund, R. K., Jungschaffer, D. A., & Collins, A. C. (1990) · Brain Research · doi:10.1016/0006-8993(90)90160-d · Cited by 24 · see citing works
Self-citationWang, J., Gutala, R. V., Hwang, Y. Y., Kim, J. ‐., Konu, Ö., Ma, J. Z., & Li, M. D. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00328.x · Cited by 23 · see citing works
“A low dose of nicotine increases the locomotor activity in C3H/HeJ mice but depresses it in C57BL/6 mice (Marks et al. 1983).”
BackgroundVillégier, A., Salomon, L., Blanc, G., Godeheu, G., Glowinski, J., & Tassin, J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05011.x · Cited by 21 · see citing works
Lewis, A. S., & Picciotto, M. R. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107929 · Cited by 23 · see citing works
“Consistent with the highly strain-dependent effects of nicotine (Crawley et al., 1997; Marks et al., 1983), antiaggressive or “serenic” doses differed considerably across strains, though as in the rat study, the serenic response did not appear to be secondary to a hypolocomotor response (Lewis et al.”
BackgroundA strain comparison of physiological and locomotor responses of mice to diisopropylfluorosphosphate
Smolen, A., Smolen, T. N., Oh, E. I., et al. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90458-2 · Cited by 22 · see citing works
Self-citationTwenty-first century tobacco use: it is not just a risk factor anymore
KHURANA, S., Batra, V., Patkar, A. A., & Leone, F. T. (2003) · Respiratory Medicine · doi:10.1053/rmed.2002.1443 · Cited by 22 · see citing works
Locomotor reactivity to a novel environment and sensitivity to MK-801 in five strains of mice
Kalinichev, M., Bate, S. T., Coggon, S. A., & Jones, D. N. C. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282f3cf48 · Cited by 21 · see citing works
“A large body of evidence confirmed significant differences in the variety of spontaneous behaviours and in sensitivity to drugs among mouse strains (Brase et al., 1977; Marks et al., 1983; Jones et al., 1996; Bouwknecht and Paylor, 2002; Cabib et al., 2002).”
BackgroundTranscriptional and epigenetic regulation of microglia in substance use disorders
Vilca, S. J., Margetts, A. V., Pollock, T. A., & Tuesta, L. M. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103838 · Cited by 19 · see citing works
Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice
Umezu, T. (2012) · ISRN Pharmacology · doi:10.5402/2012/170981 · Cited by 18 · see citing works
“International Scholarly Research Network ISRN Pharmacology Volume 2012, Article ID 170981, 12 pages doi:10.5402/2012/170981”
BackgroundInfluentialGenetic influences on tolerance development with chronic oxotremorine infusion
Marks, M. J., Romm, E., & Collins, A. C. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90200-0 · Cited by 18 · see citing works
Self-citationNicotine effects on the activity of mice exposed prenatally to the nicotinic agonist anatoxin-a
MacPhail, R. C., Farmer, J. D., Jarema, K. A., & Chernoff, N. (2005) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2005.05.004 · Cited by 18 · see citing works
Dissociation of decreased numbers of muscarinic receptors from tolerance to DFP
Smolen, T. N., Smolen, A., & Collins, A. C. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90125-5 · Cited by 18 · see citing works
Self-citationCollins, A. C., Marks, M. J., & Pauly, J. R. (1989) · Journal of Substance Abuse · doi:10.1016/s0899-3289(18)30004-x · Cited by 17 · see citing works
Self-citationThe effect of alcohol and nicotine abuse on gene expression in the brain
Flatscher‐Bader, T., & Wilce, P. A. (2009) · Nutrition Research Reviews · doi:10.1017/s0954422409990114 · Cited by 18 · see citing works
“C3H/HeJ mice self-administer less nicotine((57)) and a low dose of nicotine increases locomotor activity in C3H/HeJ mice but depresses it in C57BL/6J mice((58)).”
BackgroundLee, A. M., Calarco, C. A., McKee, S. A., Mineur, Y. S., & Picciotto, M. R. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12601 · Cited by 17 · see citing works
Pharmacogenetics of Drugs of Abuse
Shuster, L. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb21007.x · Cited by 17 · see citing works
Rorabaugh, B. R., Sprague, L., Norman, H., Seeley, S. L., & D’Souza, M. S. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14100 · Cited by 16 · see citing works
Genetic dissection of nicotine-related behaviour: a review of animal studies
Mohammed, A. H. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00198-4 · Cited by 16 · see citing works
- Authors
- Marks, M. J., Burch, J. B., & Collins, A. C.
- ORCID
- Burch, J B
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1983-07
- Volume
- 226
- Issue
- 1
- Pages
- 291-302
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W1938084083
- Cited by
- 140
- References
- 0
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotine, inbred mouse strains, nicotinic acetylcholine receptors, alpha-bungarotoxin binding, nicotine binding, locomotor activity, open field behavior, rotarod performance, body temperature, respiration, startle response, brain regions, BALB/c mice, C57BL/6 mice, DBA/2 mice, C3H mice
- MeSH terms
- Animals, Behavior, Animal, Body Temperature, Brain, Bungarotoxins, Dose-Response Relationship, Drug, Female, Male, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains, Motor Activity, Nicotine, Respiration, Reflex, Startle, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
