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A review of MRI findings in schizophrenia
Open accessAbstract
After more than 100 years of research, the neuropathology of schizophrenia remains unknown and this is despite the fact that both Kraepelin (1919/1971: Kraepelin, E., 1919/1971. Dementia praecox. Churchill Livingston Inc., New York) and Bleuler (1911/1950: Bleuler, E., 1911/1950. Dementia praecox or the group of schizophrenias. International Universities Press, New York), who first described 'dementia praecox' and the 'schizophrenias', were convinced that schizophrenia would ultimately be linked to an organic brain disorder. Alzheimer (1897: Alzheimer, A., 1897. Beitrage zur pathologischen anatomie der hirnrinde und zur anatomischen grundlage einiger psychosen. Monatsschrift fur Psychiarie und Neurologie. 2, 82-120) was the first to investigate the neuropathology of schizophrenia, though he went on to study more tractable brain diseases. The results of subsequent neuropathological studies were disappointing because of conflicting findings. Research interest thus waned and did not flourish again until 1976, following the pivotal computer assisted tomography (CT) finding of lateral ventricular enlargement in schizophrenia by Johnstone and colleagues. Since that time significant progress has been made in brain imaging, particularly with the advent of magnetic resonance imaging (MRI), beginning with the first MRI study of schizophrenia by Smith and coworkers in 1984 (Smith, R.C., Calderon, M., Ravichandran, G.K., et al. (1984). Nuclear magnetic resonance in schizophrenia: A preliminary study. Psychiatry Res. 12, 137-147). MR in vivo imaging of the brain now confirms brain abnormalities in schizophrenia. The 193 peer reviewed MRI studies reported in the current review span the period from 1988 to August, 2000. This 12 year period has witnessed a burgeoning of MRI studies and has led to more definitive findings of brain abnormalities in schizophrenia than any other time period in the history of schizophrenia research. Such progress in defining the neuropathology of schizophrenia is largely due to advances in in vivo MRI techniques. These advances have now led to the identification of a number of brain abnormalities in schizophrenia. Some of these abnormalities confirm earlier post-mortem findings, and most are small and subtle, rather than large, thus necessitating more advanced and accurate measurement tools. These findings include ventricular enlargement (80% of studies reviewed) and third ventricle enlargement (73% of studies reviewed). There is also preferential involvement of medial temporal lobe structures (74% of studies reviewed), which include the amygdala, hippocampus, and parahippocampal gyrus, and neocortical temporal lobe regions (superior temporal gyrus) (100% of studies reviewed). When gray and white matter of superior temporal gyrus was combined, 67% of studies reported abnormalities. There was also moderate evidence for frontal lobe abnormalities (59% of studies reviewed), particularly prefrontal gray matter and orbitofrontal regions. Similarly, there was moderate evidence for parietal lobe abnormalities (60% of studies reviewed), particularly of the inferior parietal lobule which includes both supramarginal and angular gyri. Additionally, there was strong to moderate evidence for subcortical abnormalities (i.e. cavum septi pellucidi-92% of studies reviewed, basal ganglia-68% of studies reviewed, corpus callosum-63% of studies reviewed, and thalamus-42% of studies reviewed), but more equivocal evidence for cerebellar abnormalities (31% of studies reviewed). The timing of such abnormalities has not yet been determined, although many are evident when a patient first becomes symptomatic. There is, however, also evidence that a subset of brain abnormalities may change over the course of the illness. The most parsimonious explanation is that some brain abnormalities are neurodevelopmental in origin but unfold later in development, thus setting the stage for the development of the symptoms of schizophrenia. Or there may be additional factors, such as stress or neurotoxicity, that occur during adolescence or early adulthood and are necessary for the development of schizophrenia, and may be associated with neurodegenerative changes. Importantly, as several different brain regions are involved in the neuropathology of schizophrenia, new models need to be developed and tested that explain neural circuitry abnormalities effecting brain regions not necessarily structurally proximal to each other but nonetheless functionally interrelated. (ABSTRACT TRUNCATED)
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“whereas adult-onset schizophrenia (the more typical form) is more strongly associated with deficits in later-maturing temporal and frontal regions (53–55) and is associated with selective abnormalities of the heteromodal regions (29).”
From Dynamic mapping of human cortical development during childhood through early adulthood (2004) · cites this paper as [53]
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“Schizophrenia is associated with loss of brain tissue, in particular in the frontal and temporal cortices as well as in some subcortical structures. 1,2”
From Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls. (2015) · cites this paper as [2]
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Cites
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Morphometric Tools for Landmark Data
Bookstein, F. L. (1992) · Cambridge University Press eBooks · doi:10.1017/cbo9780511573064 · Cited by 4,481
Dementia Praecox or the Group of Schizophrenias
(1951) · Journal of the American Medical Association · doi:10.1001/jama.1951.02920270079043 · Cited by 4,407
Le Bihan, D., Breton, E., Lallemand, D., Grenier, P., Cabanis, E., & Laval-Jeantet, M. (1986) · Radiology · doi:10.1148/radiology.161.2.3763909 · Cited by 3,912
Meta-analysis in social research
(1982) · Evaluation and Program Planning · doi:10.1016/0149-7189(82)90011-8 · Cited by 3,896
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072
Research works printed but not linked: 10
- Altshuler, 1998, Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: an MRI study demonstrating neuroanatomic specificity [letter], Arch. Gen. Psychiatry, 55, 663
- Anderson, 1998, Anatomy Browser: Java based interactive teaching tool for learning human neuroanatomy, RSNA Electronic Journal, 2, 50
- Gruzelier, 1991, Hemispheric imbalance: syndromes of schizophrenia, premorbid personality, and neurodevelopmental influences, vol. 5, 599
- Hecker, 1871, Die hebephrenic, Arch. Patholiche Anat. und fur Physiol. Klinische Medicin., 52, 394
- Hier, 1978, Autism-association with reversed cerebral asymmetry, Neurology, 28, 348
- LeMay, 1986, Leftright temporal region asymmetry in infants and children [letter], AJNR Am. J. Neuroradiol., 7, 974
- Scheibel, 1981, Disorientation of the hippocampal pyramidal cell and its processes in the schizophrenic patient, Biol. Psychiatry, 16, 101
- Shelton, 1986, X-ray computerized tomography studies in schizophrenia: a review and synthesis, vol. I, 207
- Shenton, 1996, Temporal lobe structural abnormalities in schizophrenia: a selective review and presentation of new MR findings, 51
- Shenton, 1997, A review of magnetic resonance imaging studies of brain abnormalities in schizophrenia, 297
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Items 801–900 of 1,006
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Schmitt, A., Bauer, M., Heinsen, H., Feiden, W., Falkai, P., Alafuzoff, I. I., Arzberger, T., Al‐Sarraj, S., Bell, J. E., Bogdanović, N., et al. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0601-8 · Cited by 52
Yoshihara, Y., Sugihara, G., Matsumoto, H., John Suckling, A., Nishimura, K., Toyoda, T., Isoda, H., Tsuchiya, K. J., Takebayashi, K., Suzuki, K., et al. (2008) · Annals of General Psychiatry · doi:10.1186/1744-859x-7-25 · Cited by 51
Prasad, K. M. R., Rohm, B. R., & Keshavan, M. S. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.01.017 · Cited by 51
Progression of Brain Volume Changes in Adolescent-Onset Psychosis
Reig, S., Moreno, C., Moreno, D. M., Burdalo, M. T., Janssen, J., Parellada, M., Zabala, A., Desco, M., & Arango, C. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm160 · Cited by 52
Neurotoxicity, Neuroplasticity, and Magnetic Resonance Imaging Morphometry
Mathalon, D. H., Rapoport, J. L., Davis, K. L., & Krystal, J. H. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.846 · Cited by 51
Neurosurgery for schizophrenia: an update on pathophysiology and a novel therapeutic target
Mikell, C. B., Sinha, S. R., & Sheth, S. A. (2015) · Journal of neurosurgery · doi:10.3171/2015.4.jns15120 · Cited by 53
Joint Modeling of Anatomical and Functional Connectivity for Population Studies
Venkataraman, A., Yogesh Rathi, A., Kubicki, M. R., Westin, C., & Golland, P. (2011) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2011.2166083 · Cited by 50
Chen, J., Calhoun, V. D., Pearlson, G. D., Perrone‐Bizzozero, N. I., Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, N. Q. U. O. S. A. T., Turner, J. A., Bustillo, J., Ehrlich, S., Sponheim, S. R., Cañive, J. M., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.073 · Cited by 51
White matter alterations in the corpus callosum of adolescents with first-admission schizophrenia
Henze, R., Brunner, R. M., Thiemann, U., Parzer, P., Klein, J., Resch, F., & Stieltjes, B. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.02.032 · Cited by 50
Prefrontal atrophy in first episodes of schizophrenia associated with limbic metabolic hyperactivity
Molina, V., Sanz, J., Sarramea, F., Benito, C., & Palomo, T. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.06.008 · Cited by 51
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Liemburg, E. J., Vercammen, A., Horst, G. J. T., Ćurĉić‐Blake, B., Knegtering, H., & Aleman, A. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2011.12.003 · Cited by 52
Xiao, M., Ge, H., Khundrakpam, B. S., Xu, J., Bezgin, G., Leng, Y., Zhao, L., Tang, Y., Ge, X., Jeon, S., et al. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00194 · Cited by 48
Chung, Y., Haut, K. M., He, G. S., van Erp, T. G. M., McEwen, S. C., Addington, J., Bearden, C. E., Cadenhead, K. S., Cornblatt, B. A., Mathalon, D. H., et al. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.02.014 · Cited by 50
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Iannitelli, A., Quartini, A., Tirassa, P., & Bersani, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.010 · Cited by 52
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Lin, Y., Ding, H., & Zhang, Y. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100363 · Cited by 50
Cyr, M., Caron, M. G., Johnson, G. A., & Laakso, A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.039 · Cited by 50
Papiol, S., Molina, V., Desco, M., Rosa, A., Reig, S., Gispert, J. D., Sanz, J., Palomo, T., & Fañanás, L. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.05.035 · Cited by 50
Shashi, V., Muddasani, S., dos Santos, C. C., Berry, M. N., Kwapil, T. R., Lewandowski, K. E., & Keshavan, M. S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.12.004 · Cited by 50
Visual White Matter Integrity in Schizophrenia
Butler, P. D., Hoptman, M. J., Nierenberg, J. J., Foxe, J. J., Javitt, D. C., & Lim, K. O. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.2011 · Cited by 50
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Konopaske, G. T., Sweet, R. A., Wu, Q., Sampson, A. R., & Lewis, D. A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.070 · Cited by 50
Zinkstok, J., & van Amelsvoort, T. (2005) · Child Neuropsychology · doi:10.1080/09297040590911194 · Cited by 49
Halari, R., Mehrotra, R., Sharma, T., Ng, V., & Kumari, V. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2005.07.021 · Cited by 49
Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study
Rosenberger, G., Nestor, P. G., Oh, J. S., Levitt, J. J., Kindleman, G., Sylvain Bouix, A., Fitzsimmons, J., Niznikiewicz, M. A., Westin, C., Kikinis, R., et al. (2012) · Brain Imaging and Behavior · doi:10.1007/s11682-012-9152-9 · Cited by 47
Self-citationAbazyan, B., Dziedzic, J., Hua, K., Abazyan, S., Yang, C., Mori, S., Pletnikov, M., & Guilarte, T. (2014) · Schizophrenia bulletin · doi:10.1093/schbul/sbt071 · Cited by 54
Wible, C. G., Preus, A. P., & Hashimoto, R. (2008) · Brain Imaging and Behavior · doi:10.1007/s11682-008-9052-1 · Cited by 50
de Wit, S., Wierenga, L. M., Oranje, B., Ziermans, T. B., Schothorst, P. F., van Engeland, H., Kahn, R. S., & Durston, S. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.08.013 · Cited by 49
Ftouh, S., Akbar, M. T., Hirsch, S. R., & de Belleroche, J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03239.x · Cited by 48
Inter-rater reliability of manual segmentation of the superior, inferior and middle frontal gyri
John, J. P., Wang, L., Moffitt, A. J., Singh, H. K., Gado, M. H., & Csernansky, J. G. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.05.006 · Cited by 49
22q11.2 Deletion Syndrome: Genetics, Neuroanatomy and Cognitive/Behavioral Features Keywords
Antshel, K. M., Kates, W. R., Roizen, N., Fremont, W. P., & Shprintzen, R. J. (2005) · Child Neuropsychology · doi:10.1080/09297040590911185 · Cited by 49
Pseudo-continuous arterial spin labeling MRI study of schizophrenic patients
Ota, M., Ishikawa, M., Sato, N., Okazaki, M., Maikusa, N., Hori, H., Hattori, K., Teraishi, T., Ito, K., & Kunugi, H. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.01.035 · Cited by 48
Ronan, L., Voets, N., Hough, M., Mackay, C. E., Roberts, N., Suckling, J., Bullmore, E. T., James, A. C., & Fletcher, P. C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.034 · Cited by 49
The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia.
Takahashi, T., Suzuki, M., Tsunoda, M., Maeno, N., Kawasaki, Y., Zhou, S.-Y., Hagino, H., Niu, L., Tsuneki, H., Kobayashi, S., et al. (2009) · Psychiatry Research · doi:10.1016/j.pscychresns.2009.01.005 · Cited by 56
Rosso, I. M., Makris, N., Thermenos, H. W., Hodge, S. M., Brown, A., Kennedy, D. N., Caviness, V. S., Faraone, S. V., Tsuang, M. T., & Seidman, L. J. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.06.015 · Cited by 48
Song, X., Fan, X., Li, X., Kennedy, D. N., Pang, L., Quan, M., Chen, X., Gao, J., Zhang, W., Zhang, J., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.033 · Cited by 48
Dutt, A., Tseng, H., Fonville, L., Drakesmith, M., Su, L., Evans, J., Zammit, S., Jones, D. K., Lewis, G., & David, A. S. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.08.018 · Cited by 48
Reduced language lateralization in first-episode medication-naive schizophrenia
van Veelen, N. M. J., Vink, M., Ramsey, N. F., Sommer, I. E., van Buuren, M., Bas‐Hoogendam, J. M., & Kahn, R. S. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2010.12.013 · Cited by 48
Morbid risk for schizophrenia in first-degree relatives of people with frontotemporal dementia
Schoder, D., Hannequin, D., Martinaud, O., Opolczynski, G., Guyant‐Maréchal, L., Ber, I. L., & Campion, D. (2010) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.109.068981 · Cited by 46
Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia
Wigand, M. C. C., Kubicki, M. R., von Hohenberg, C. C., Leicht, G., Karch, S., Eckbo, R., Pelavin, P. E., Hawley, K. J., Rujescu, D., Sylvain Bouix, A., et al. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2014.948063 · Cited by 48
Self-citationSormunen, E., Saarinen, M. M., Salokangas, R. K. R., Telama, R., Hutri‐Kähönen, N., Tammelin, T., Viikari, J. S. A., Raitakari, O. T., & Hietala, J. A. (2017) · Schizophrenia · doi:10.1038/s41537-016-0007-z · Cited by 48
Molecular imaging of schizophrenia: Neurochemical findings in a heterogeneous and evolving disorder
Cumming, P. D., Abi‐Dargham, A., & Gründer, G. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113004 · Cited by 53
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Bozikas, V. P., Γιαννάκου, Μ., Kosmidis, M. H., Kargopoulos, P., Kioseoglou, G., Liolios, D., & Garyfallos, G. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.04.025 · Cited by 48
Hippocampal dysfunction during free word association in male patients with schizophrenia
Kircher, T. T. J., Whitney, C., Krings, T., Huber, W., & Weis, S. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.02.003 · Cited by 52
Exploring imagined movements in patients with schizophrenia
Danckert, J. A., Rossetti, Y., d’Amato, T., Jean Dalery, A., & Saoud, M. (2002) · Neuroreport · doi:10.1097/00001756-200204160-00014 · Cited by 48
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Ardekani, B. A., Bappal, A., D’Angelo, D., Ashtari, M., Lencz, T., Szeszko, P. R., Butler, P. D., Javitt, D. C., Lim, K. O., Hrabě, J., et al. (2005) · Neuroreport · doi:10.1097/01.wnr.0000177001.27569.06 · Cited by 48
Functional brain imaging of symptoms and cognition in schizophrenia
Kircher, T. T. J., & Thienel, R. (2005) · Progress in brain research · doi:10.1016/s0079-6123(05)50022-0 · Cited by 47
Goulet, K., Deschamps, B., Evoy, F., & Trudel, J.-F. (2009) · The Canadian Journal of Psychiatry · doi:10.1177/070674370905400711 · Cited by 47
Premkumar, P., Fannon, D. G., Kuipers, E., Cooke, M. A., Simmons, A., & Kumari, V. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.05.012 · Cited by 46
Takahashi, T., Suzuki, M., Tsunoda, M., Kawamura, Y., Takahashi, N., Tsuneki, H., Kawasaki, Y., Zhou, S.-Y., Kobayashi, S., Sasaoka, T., et al. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.02.004 · Cited by 46
Bhojraj, T. S., Francis, A., Rajarethinam, R., Eack, S. M., Kulkarni, S., Prasad, K. M. R., Montrose, D. M., Dworakowski, D., Diwadkar, V. A., & Keshavan, M. S. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.09.033 · Cited by 47
Reetz, K., Lencer, R., Steinlechner, S., Gaser, C., Hagenah, J. M., Büchel, C., Petersen, D., Kock, N., Djarmati, A., Siebner, H. R., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.12.010 · Cited by 49
Evidence of gray matter reduction and dysfunction in chromosome 22q11.2 deletion syndrome
Shashi, V., Kwapil, T. R., Kaczorowski, J. A., Berry, M. N., Santos, C. S., Howard, T. D., Goradia, D. D., Prasad, K. M. R., Vaibhav, D., Rajarethinam, R., et al. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.07.003 · Cited by 48
Phospholipase A2 activity is associated with structural brain changes in schizophrenia
Smesny, S., Milleit, B., Nenadić, I., Preul, C., Kinder, D., Lasch, J., Willhardt, I., Sauer, H., & Gaser, C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.05.009 · Cited by 46
López-García, P., Aizenstein, H. J., Snitz, B. E., Walter, R. P., & Carter, C. S. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.04.007 · Cited by 47
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Penttilä, J., Martinot, M. P., Martinot, J., Mangin, J., Burke, L., Corrigall, R. J., Frangou, S., & Cachia, A. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181825aa7 · Cited by 51
Work and Unemployment as Stressors
Lennon, M. C., & Limonic, L. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511984945.015 · Cited by 46
Unawareness in schizophrenia: Neuropsychological and neuroanatomical findings
Pia, L., & Tamietto, M. (2006) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2006.01576.x · Cited by 46
Cortical Signature of Neurological Soft Signs in Recent Onset Schizophrenia
Hirjak, D., Wolf, R. C., Stieltjes, B., Hauser, T., Seidl, U., Schröder, J., & Thomann, P. A. (2013) · Brain Topography · doi:10.1007/s10548-013-0292-z · Cited by 46
Kurosawa, S., Hashimoto, E., Ukai, W., Toki, S., Saitô, S., & Saito, T. (2007) · Journal of Neural Transmission · doi:10.1007/s00702-007-0747-z · Cited by 46
Regional cortical thinning in subjects with high genetic loading for schizophrenia
Byun, M. S., Kim, J. S., Jung, W. H., Jang, J. H., Choi, J., Kim, S. N., Choi, C., Chung, C. K., An, S. K., & Kwon, J. S. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.08.028 · Cited by 46
Prospective memory in schizophrenia: The impact of varying retrospective-memory load
Altgassen, M., Kliegel, M., Rendell, P. G., Henry, J. D., & Zöllig, J. (2008) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390701779552 · Cited by 49
Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus
Stevens, H. E., Jiang, G. Y., Schwartz, M. L., & Vaccarino, F. M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.013 · Cited by 48
Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophrenia
Kubicki, M. R., Alvarado, J. L., Westin, C., Tate, D. F., Markant, D. B., Terry, D. P., Whitford, T. J., Siebenthal, J. D., Sylvain Bouix, A., McCarley, R. W., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.01.047 · Cited by 48
Self-citationBrain volume and dysexecutive behavior in schizophrenia
Kawada, R., Yoshizumi, M., Hirao, K., Fujiwara, H., Miyata, J., Shimizu, M., Namiki, C., Sawamoto, N., Fukuyama, H., Hayashi, T., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.07.014 · Cited by 46
Ragland, J. D., Valdez, J. N., Loughead, J., Gur, R. C., & Gur, R. E. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.05.008 · Cited by 48
Mental illness is indeed a myth
Pickard, H. (2009) · Oxford University Press eBooks · doi:10.1093/med/9780199238033.003.0005 · Cited by 46
Eom, T.-Y., Han, S. B., Kim, J., Blundon, J. A., Wang, Y., Yu, J., Anderson, K., Kaminski, D. B., Sakurada, S. M., Pruett‐Miller, S. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14628-y · Cited by 47
The BOLD onset transient: identification of novel functional differences in schizophrenia
Fox, M., Snyder, A. Z., McAvoy, M. P., Barch, D. M., & Raichle, M. E. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.025 · Cited by 46
Reduced hippocampal anisotropy related to anteriorization of alpha EEG in schizophrenia
Begré, S., Federspiel, A., Kiefer, C., Schroth, G., Dierks, T., & Strik, W. K. (2003) · Neuroreport · doi:10.1097/00001756-200304150-00016 · Cited by 46
Narr, K. L., Sharma, T., Woods, R. P., Thompson, P. M., Sowell, E. R., Rex, D., Kim, S. H., Asuncion, D. M., Jang, S., Mazziotta, J. C., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.12.2169 · Cited by 46
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Hirjak, D., Wolf, R. C., Stieltjes, B., Seidl, U., Schröder, J., & Thomann, P. A. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.01.015 · Cited by 45
Comorbid substance abuse and brain morphology in recent-onset psychosis
Wobrock, T., Sittinger, H., Behrendt, B., D’Amelio, R., & Falkai, P. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0831-x · Cited by 45
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Pankow, A., Knobel, A., Voss, M., & Heinz, A. (2012) · Neuropsychobiology · doi:10.1159/000337132 · Cited by 48
Mukherjee, P., Whalley, H. C., McKirdy, J. W., McIntosh, A. M., Johnstone, E. C., Lawrie, S. M., & Hall, J. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.09.033 · Cited by 48
Forsyth, J. K., Ellman, L. M., Tanskanen, A. J., Mustonen, U., HUTTUNEN, M. O., Suvisaari, J., & Cannon, T. D. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs098 · Cited by 45
Spared and impaired aspects of motivated cognitive control in schizophrenia.
Mann, C. L., Footer, O., Chung, Y. S., Driscoll, L. L., & Barch, D. M. (2013) · Journal of Abnormal Psychology · doi:10.1037/a0033069 · Cited by 50
Jørgensen, K. N., Nesvåg, R., Gunleiksrud, S., Raballo, A., Jönsson, E. G., & Agartz, I. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-015-0650-9 · Cited by 46
Cortical white-matter microstructure in schizophrenia
Andreone, N., Tansella, M., Cerini, R., Versace, A., Rambaldelli, G., Perlini, C., Dusi, N., Pelizza, L., Balestrieri, M., Barbui, C., et al. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.105.020990 · Cited by 45
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Gururajan, A., & Malone, D. T. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.06.022 · Cited by 51
del Re, E. C., Stone, W. S., Sylvain Bouix, A., Seitz, J., Zeng, V., Guliano, A., Somes, N., Zhang, T., Reid, B. E., Lyall, A. E., et al. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa127 · Cited by 45
Self-citationExpression of immune genes on chromosome 6p21.3–22.1 in schizophrenia
Sinkus, M. L., Adams, C. E., Logel, J., Freedman, R., & Leonard, S. S. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.01.087 · Cited by 46
Jarskog, L. F., Gilmore, J. H., Glantz, L. A., Gable, K., German, T. T., Tong, R. I., & Lieberman, J. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301074 · Cited by 45
Emotion processing, the amygdala, and outcome in schizophrenia
Shayegan, D. K., & Stahl, S. M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.03.002 · Cited by 45
Zipparo, L., Whitford, T. J., Hodge, M. A., Lucas, S. K., Farrow, T. F. D., Brennan, J., Gomes, L. J., Williams, L. M., & Harris, A. W. F. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.10.011 · Cited by 44
Spencer, M. D., Moorhead, T. W. J., McIntosh, A. M., Stanfield, A. C., Muir, W. J., Hoare, P. G., Owens, D. G. C., Lawrie, S. M., & Johnstone, E. C. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.01.008 · Cited by 45
Tian, L., Meng, C., Yan, H., Zhao, Q., Liu, Q., Yan, J., Han, Y., Yuan, H., Wang, L., Yue, W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028794 · Cited by 44
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Ritsner, M. S., & Gottesman, I. I. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9464-4_1 · Cited by 45
Smoking status as a potential confounder in the study of brain structure in schizophrenia
Schneider, C. E., White, T. J. H., Haß, J., Geisler, D., Wallace, S. R., Roessner, V., Holt, D. J., Calhoun, V. D., Gollub, R. L., & Ehrlich, S. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.12.004 · Cited by 44
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Tognin, S., Riecher‐Rössler, A., Meisenzahl, E. M., Wood, S. J., Hutton, C., Borgwardt, S., Koutsouleris, N., Yung, A. R., Allen, P., Phillips, L., et al. (2013) · Psychological Medicine · doi:10.1017/s0033291713000998 · Cited by 44
Gray Matter Volumetric Abnormalities Associated with the Onset of Psychosis
Jung, W. H., Borgwardt, S., Fusar‐Poli, P., & Kwon, J. S. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00101 · Cited by 43
Impact of cannabis use on thalamic volume in people at familial high risk of schizophrenia
Welch, K. A., Stanfield, A. C., McIntosh, A. M., Whalley, H. C., Job, D. E., Moorhead, T. W. J., Owens, D. G. C., Lawrie, S. M., & Johnstone, E. C. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.090175 · Cited by 44
The effect of ageing on grey and white matter reductions in schizophrenia
Bose, S. K., Mackinnon, T., Mehta, M. A., Turkheimer, F., Howes, O. D., Selvaraj, S., Kempton, M. J., & Grasby, P. M. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.04.023 · Cited by 44
Yılmaz, P. T., Aydın, M., & İlhan, B. Ç. (2018) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2018.1426693 · Cited by 44
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Allswede, D. M., & Cannon, T. D. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000317 · Cited by 46
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Gröhn, C. F., Norgren, E., & Eriksson, L. G. (2021) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2021.100219 · Cited by 43
Abnormal processing of speech during oddball target detection in schizophrenia
Ngan, E. T. C., Vouloumanos, A., Cairo, T. A., Laurens, K. R., Bates, A. T., Anderson, C. M., Werker, J. F., & Liddle, P. F. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00385-9 · Cited by 44
Formal thought disorder in non-clinical individuals with auditory verbal hallucinations
Sommer, I. E., Derwort, A. M. C., Daalman, K., de Weijer, A. D., Liddle, P. F., & Boks, M. P. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.01.024 · Cited by 44
Molina, V., Reig, S., Pascau, J., Sanz, J., Sarramea, F., Gispert, J. D., Luque, R., Benito, C., Palomo, T., & Desco, M. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00107-0 · Cited by 44
Arachnoid cyst in a patient with psychosis: Case report
da Silva, J. A., Alves, A., Talina, M. C., Carreiro, S. V., Guimarães, J., & Xavier, M. (2007) · Annals of General Psychiatry · doi:10.1186/1744-859x-6-16 · Cited by 44
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Bebbington, P. (2009) · Epidemiology and Psychiatric Sciences · doi:10.1017/s1121189x00000233 · Cited by 43
Shen, M., Wen, P. P., Song, B., & Li, Y. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107022 · Cited by 48
Metadata
- Authors
- Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W.
- Affiliations
- Harvard University (US)
- Corresponding author
- Shenton, Martha E.
- McCarley, Robert W.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 49
- Issue
- 1-2
- Pages
- 1-52
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC2812015
- OpenAlex
- W1985994929
- Cited by
- 2,346
- References
- 480
- Citations by year
- 2026: 21 · 2025: 47 · 2024: 35 · 2023: 52 · 2022: 51 · 2021: 69 · 2020: 57 · 2019: 72 · 2018: 62 · 2017: 99 · 2016: 81 · 2015: 110 · 2014: 98 · 2013: 107 · 2012: 143
- FWCI
- 16.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- U.S. Department of Veterans Affairs
- University of Cambridge
- National Institute of Mental Health (MH-01110, MH-50740, MH40799, K02MH001110, R01MH050740, R01MH040799)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- schizophrenia, brain abnormalities
- MeSH terms
- Brain, Humans, Magnetic Resonance Imaging, Psychotic Disorders, Schizophrenia
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