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A review of MRI findings in schizophrenia
Open accessAbstract
After more than 100 years of research, the neuropathology of schizophrenia remains unknown and this is despite the fact that both Kraepelin (1919/1971: Kraepelin, E., 1919/1971. Dementia praecox. Churchill Livingston Inc., New York) and Bleuler (1911/1950: Bleuler, E., 1911/1950. Dementia praecox or the group of schizophrenias. International Universities Press, New York), who first described 'dementia praecox' and the 'schizophrenias', were convinced that schizophrenia would ultimately be linked to an organic brain disorder. Alzheimer (1897: Alzheimer, A., 1897. Beitrage zur pathologischen anatomie der hirnrinde und zur anatomischen grundlage einiger psychosen. Monatsschrift fur Psychiarie und Neurologie. 2, 82-120) was the first to investigate the neuropathology of schizophrenia, though he went on to study more tractable brain diseases. The results of subsequent neuropathological studies were disappointing because of conflicting findings. Research interest thus waned and did not flourish again until 1976, following the pivotal computer assisted tomography (CT) finding of lateral ventricular enlargement in schizophrenia by Johnstone and colleagues. Since that time significant progress has been made in brain imaging, particularly with the advent of magnetic resonance imaging (MRI), beginning with the first MRI study of schizophrenia by Smith and coworkers in 1984 (Smith, R.C., Calderon, M., Ravichandran, G.K., et al. (1984). Nuclear magnetic resonance in schizophrenia: A preliminary study. Psychiatry Res. 12, 137-147). MR in vivo imaging of the brain now confirms brain abnormalities in schizophrenia. The 193 peer reviewed MRI studies reported in the current review span the period from 1988 to August, 2000. This 12 year period has witnessed a burgeoning of MRI studies and has led to more definitive findings of brain abnormalities in schizophrenia than any other time period in the history of schizophrenia research. Such progress in defining the neuropathology of schizophrenia is largely due to advances in in vivo MRI techniques. These advances have now led to the identification of a number of brain abnormalities in schizophrenia. Some of these abnormalities confirm earlier post-mortem findings, and most are small and subtle, rather than large, thus necessitating more advanced and accurate measurement tools. These findings include ventricular enlargement (80% of studies reviewed) and third ventricle enlargement (73% of studies reviewed). There is also preferential involvement of medial temporal lobe structures (74% of studies reviewed), which include the amygdala, hippocampus, and parahippocampal gyrus, and neocortical temporal lobe regions (superior temporal gyrus) (100% of studies reviewed). When gray and white matter of superior temporal gyrus was combined, 67% of studies reported abnormalities. There was also moderate evidence for frontal lobe abnormalities (59% of studies reviewed), particularly prefrontal gray matter and orbitofrontal regions. Similarly, there was moderate evidence for parietal lobe abnormalities (60% of studies reviewed), particularly of the inferior parietal lobule which includes both supramarginal and angular gyri. Additionally, there was strong to moderate evidence for subcortical abnormalities (i.e. cavum septi pellucidi-92% of studies reviewed, basal ganglia-68% of studies reviewed, corpus callosum-63% of studies reviewed, and thalamus-42% of studies reviewed), but more equivocal evidence for cerebellar abnormalities (31% of studies reviewed). The timing of such abnormalities has not yet been determined, although many are evident when a patient first becomes symptomatic. There is, however, also evidence that a subset of brain abnormalities may change over the course of the illness. The most parsimonious explanation is that some brain abnormalities are neurodevelopmental in origin but unfold later in development, thus setting the stage for the development of the symptoms of schizophrenia. Or there may be additional factors, such as stress or neurotoxicity, that occur during adolescence or early adulthood and are necessary for the development of schizophrenia, and may be associated with neurodegenerative changes. Importantly, as several different brain regions are involved in the neuropathology of schizophrenia, new models need to be developed and tested that explain neural circuitry abnormalities effecting brain regions not necessarily structurally proximal to each other but nonetheless functionally interrelated. (ABSTRACT TRUNCATED)
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“whereas adult-onset schizophrenia (the more typical form) is more strongly associated with deficits in later-maturing temporal and frontal regions (53–55) and is associated with selective abnormalities of the heteromodal regions (29).”
From Dynamic mapping of human cortical development during childhood through early adulthood (2004) · cites this paper as [53]
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“Schizophrenia is associated with loss of brain tissue, in particular in the frontal and temporal cortices as well as in some subcortical structures. 1,2”
From Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls. (2015) · cites this paper as [2]
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Cites
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Morphometric Tools for Landmark Data
Bookstein, F. L. (1992) · Cambridge University Press eBooks · doi:10.1017/cbo9780511573064 · Cited by 4,481
Dementia Praecox or the Group of Schizophrenias
(1951) · Journal of the American Medical Association · doi:10.1001/jama.1951.02920270079043 · Cited by 4,407
Le Bihan, D., Breton, E., Lallemand, D., Grenier, P., Cabanis, E., & Laval-Jeantet, M. (1986) · Radiology · doi:10.1148/radiology.161.2.3763909 · Cited by 3,912
Meta-analysis in social research
(1982) · Evaluation and Program Planning · doi:10.1016/0149-7189(82)90011-8 · Cited by 3,896
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072
Research works printed but not linked: 10
- Altshuler, 1998, Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: an MRI study demonstrating neuroanatomic specificity [letter], Arch. Gen. Psychiatry, 55, 663
- Anderson, 1998, Anatomy Browser: Java based interactive teaching tool for learning human neuroanatomy, RSNA Electronic Journal, 2, 50
- Gruzelier, 1991, Hemispheric imbalance: syndromes of schizophrenia, premorbid personality, and neurodevelopmental influences, vol. 5, 599
- Hecker, 1871, Die hebephrenic, Arch. Patholiche Anat. und fur Physiol. Klinische Medicin., 52, 394
- Hier, 1978, Autism-association with reversed cerebral asymmetry, Neurology, 28, 348
- LeMay, 1986, Leftright temporal region asymmetry in infants and children [letter], AJNR Am. J. Neuroradiol., 7, 974
- Scheibel, 1981, Disorientation of the hippocampal pyramidal cell and its processes in the schizophrenic patient, Biol. Psychiatry, 16, 101
- Shelton, 1986, X-ray computerized tomography studies in schizophrenia: a review and synthesis, vol. I, 207
- Shenton, 1996, Temporal lobe structural abnormalities in schizophrenia: a selective review and presentation of new MR findings, 51
- Shenton, 1997, A review of magnetic resonance imaging studies of brain abnormalities in schizophrenia, 297
Cited by
Sorted by citations
Items 101–200 of 1,006
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Tamminga, C. A., & Holcomb, H. H. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001563 · Cited by 263
Fornito, A., Yucel, M., Dean, B., Wood, S. J., & Pantelis, C. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn025 · Cited by 259
Lui, S., Deng, W., Huang, X., Jiang, L., Ma, X., Chen, H., Zhang, T., Li, X., Li, D., Zou, L., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08020183 · Cited by 258
Steen, R. G., Hamer, R. M., & Lieberman, J. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300850 · Cited by 254
Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology
Abazyan, B., Nomura, J., Kannan, G., Ishizuka, K., Tamashiro, K. L., Nucifora, F., Pogorelov, V., Ladenheim, B., Yang, C., Krasnova, I. N., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.022 · Cited by 255
Hashimoto, R., Numakawa, T., Ohnishi, T., Kumamaru, E., Yagasaki, Y., Ishimoto, T., Mori, T., Nemoto, K., Adachi, N., Izumi, A., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl244 · Cited by 247
Effects of antipsychotics on brain structure
Scherk, H., & Falkai, P. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000214339.06507.d8 · Cited by 245
Christian Gaser, B. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg107 · Cited by 245
MRI study of white matter diffusion anisotropy in schizophrenia
Ardekani, B. A., Nierenberg, J. J., Hoptman, M. J., Javitt, D. C., & Lim, K. O. (2003) · Neuroreport · doi:10.1097/00001756-200311140-00004 · Cited by 245
Risk Factors for the Emergence of Psychotic Disorders in Adolescents With 22q11.2 Deletion Syndrome
Gothelf, D., Feinstein, C., Thompson, T., Gu, E., Penniman, L. C., Stone, E. V., Kwon, H., D, S. E. M., & Reiss, A. L. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.4.663 · Cited by 240
Samartzis, L., Dima, D., Fusar‐Poli, P., & Kyriakopoulos, M. (2014) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2012.00779.x · Cited by 236
Vostrikov, V. M., Uranova, N. A., & Orlovskaya, D. D. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.04.014 · Cited by 233
Miller, C. L., Llenos, I. C., Dulay, J. R., Barillo, M. M., Yolken, R. H., & Weis, S. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.015 · Cited by 232
Gardiner, E. J., Beveridge, N. J., Wu, J. Q., Carr, V. J., Scott, R. J., Tooney, P. A., & Cairns, M. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.78 · Cited by 235
KaSP, Moberget, T., Doan, N. T., Alnæs, D., Kaufmann, T., Córdova‐Palomera, A., Lagerberg, T. V., Diedrichsen, J., Schwarz, E., Zink, M., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.106 · Cited by 228
Volumetric brain imaging findings in mood disorders
Beyer, J. L., & Krishnan, K. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01157.x · Cited by 234
Smucny, J., Dienel, S. J., Lewis, D. A., & Carter, C. S. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01089-0 · Cited by 231
Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization
Steiner, J. H., Mawrin, C., Ziegeler, A., Bielau, H., Ullrich, O., Bernstein, H., & Bogerts, B. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0090-8 · Cited by 232
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Lim, K. O., & Helpern, J. A. (2002) · NMR in Biomedicine · doi:10.1002/nbm.789 · Cited by 228
Jaroslav Flegr, A. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.073635 · Cited by 220
Ashtari, M., Cervellione, K. L., Hasan, K. M., Wu, J., McIlree, C., Kester, H. M., Ardekani, B. A., Roofeh, D., Szeszko, P. R., & Kumra, S. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.10.047 · Cited by 227
DISC1 Regulates the Transport of the NUDEL/LIS1/14-3-3ε Complex through Kinesin-1
Taya, S., Shinoda, T., Tsuboi, D., Uraguchi‐Asaki, J., Nagai, K., Hikita, T., Kuroda, S., Kuroda, K., Shimizu, M., Hirotsune, S., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3826-06.2006 · Cited by 222
Nesvåg, R., Lawyer, G., Varnäs, K., Fjell, A. M., Walhovd, K. B., Frigessi, A., Jönsson, E. G., & Agartz, I. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.09.015 · Cited by 226
Review of thalamocortical resting-state fMRI studies in schizophrenia
Giraldo‐Chica, M., & Woodward, N. D. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.08.005 · Cited by 229
Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine
Ben-Shachar, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01263.x · Cited by 232
Blokland, G. A. M., de Zubicaray, G. I., McMahon, K. L., & Wright, M. J. (2012) · Twin Research and Human Genetics · doi:10.1017/thg.2012.11 · Cited by 221
A Genome-Wide Association Study of Schizophrenia Using Brain Activation as a Quantitative Phenotype
Potkin, S. G., Turner, J. A., Guffanti, G., Lakatos, A., Fallon, J. H., Nguyen, D. D., Mathalon, D. H., Ford, J. M., Lauriello, J., & Macciardi, F. M. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn155 · Cited by 222
Patterns of Gray Matter Abnormalities in Schizophrenia Based on an International Mega-analysis
Gupta, C. N., Calhoun, V. D., Rachakonda, S., Chen, J., Patel, V., Liu, J., Segall, J., Franke, B., Zwiers, M. P., Vásquez, A. A., et al. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu177 · Cited by 219
Lodge, D. J., & Grace, A. A. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.01.031 · Cited by 221
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McIntosh, A. M., Moorhead, T. W. J., Job, D. E., Lymer, G. K. S., Maniega, S. M., McKirdy, J. W., Sussmann, J. E., Baig, B. J., Bastin, M. E., Porteous, D. J., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002103 · Cited by 215
Schizophrenia and the inferior parietal lobule
Torrey, E. F. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.08.023 · Cited by 216
Social cognition in schizophrenia: a review of face processing
Marwick, K., & Hall, J. (2008) · British Medical Bulletin · doi:10.1093/bmb/ldn035 · Cited by 214
Phang, C., Noman, F. M., Hussain, H., Ting, C., & Ombao, H. (2019) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2019.2941222 · Cited by 217
Schizophrenia, neurodevelopment and corpus callosum
Innocenti, G. M., Ansermet, F., & Parnas, J. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001205 · Cited by 207
Dietsche, B., Kircher, T. T. J., & Falkenberg, I. (2017) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867417699473 · Cited by 210
Floresco, S. B., & Tse, M. T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5474-06.2007 · Cited by 204
Barkataki, I., Kumari, V., Das, M., Taylor, P. J., & Sharma, T. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.01.009 · Cited by 205
Smieskova, R., Fusar‐Poli, P., Allen, P., Bendfeldt, K., Stieglitz, R. D., Drewe, J., Radue, E. W., McGuire, P. K., Riecher‐Rössler, A., & Borgwardt, S. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788957456 · Cited by 205
Jarskog, L. F., Selinger, E. S., Lieberman, J. A., & Gilmore, J. H. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.109 · Cited by 203
Larson, M. K., Walker, E. F., & Compton, M. T. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.93 · Cited by 203
Emotional Arousal Can Impair Feature Binding in Working Memory
Mather, M., Mitchell, K., Raye, C. L., Novak, D. L., Greene, E. J., & Johnson, M. K. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.4.614 · Cited by 199
Kelly, B. D., O’Callaghan, E., Waddington, J. L., Feeney, L., Browne, S., Scully, P. J., Clarke, M., Quinn, J. F., McTigue, O., Morgan, M. G., et al. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.10.015 · Cited by 210
Fineberg, A. M., & Ellman, L. M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.001 · Cited by 206
Honea, R. A., Meyer‐Lindenberg, A., Hobbs, K. B., Pezawas, L., Mattay, V. S., Egan, M. F., Verchinski, B. A., Passingham, R. E., Weinberger, D. R., & Callicott, J. H. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.027 · Cited by 199
Cortical Thinning in Cingulate and Occipital Cortices in First Episode Schizophrenia
Narr, K. L., Toga, A. W., Szeszko, P. R., Thompson, P. M., Woods, R. P., Robinson, D. G., Sevy, S. M., Wang, Y.-P., Schrock, K., & Bilder, R. M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.043 · Cited by 203
Morey, R. A., Inan, S., Mitchell, T. V., Perkins, D. O., Lieberman, J. A., & Belger, A. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.3.254 · Cited by 201
DeLisi, L. E. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm164 · Cited by 202
Vierling-Claassen, D., Siekmeier, P. J., Stufflebeam, S. M., & Kopell, N. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00870.2007 · Cited by 200
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Konrad, A., & Winterer, G. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm034 · Cited by 202
Cheung, V., Cheung, C. C. G., McAlonan, G. M., Deng, Y. M., Wong, J. G., Yip, L., Tai, K. S., Khong, P. L., Sham, P. C., & Chua, S. E. (2007) · Psychological Medicine · doi:10.1017/s0033291707001808 · Cited by 197
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Kreczmański, P., Heinsen, H., Mantua, V., Woltersdorf, F., Masson, T., Ulfig, N., Schmidt‐Kastner, R., Korr, H., Steinbusch, H. W. M., Hof, P. R., et al. (2007) · Brain · doi:10.1093/brain/awl386 · Cited by 196
Wood, S. J., Pantelis, C., Velakoulis, D., Yücel, M., Fornito, A., & McGorry, P. D. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm149 · Cited by 195
Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study
Wible, C. G., Anderson, J. E., Shenton, M. E., Kricun, A., Hirayasu, Y., Tanaka, S., Levitt, J. J., O’Donnell, B. F., Kikinis, R., Jolesz, F. A., et al. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00109-3 · Cited by 195
Self-citationMitochondria, Synaptic Plasticity, And Schizophrenia
Ben‐Shachar, D., & Laifenfeld, D. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)59011-6 · Cited by 191
Read, J., Bentall, R. P., & Fosse, R. (2009) · Epidemiology and Psychiatric Sciences · doi:10.1017/s1121189x00000257 · Cited by 193
Konopaske, G. T., Dorph‐Petersen, K., Pierri, J. N., Wu, Q., Sampson, A. R., & Lewis, D. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301233 · Cited by 192
Adenosine hypothesis of schizophrenia – Opportunities for pharmacotherapy
Boison, D., Singer, P., Shen, H., Feldon, J., & Yee, B. K. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.048 · Cited by 194
Auditory event-related potential abnormalities in bipolar disorder and schizophrenia
O'Donnell, B. F., Vohs, J. L., Hetrick, W. P., Carroll, C. A., & Shekhar, A. (2004) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2004.02.001 · Cited by 190
Koutsouleris, N., Christian Gaser, B., Jäger, M., Ronald Bottlender, A., Frodl, T., Holzinger, S., Schmitt, G. J. E., Zetzsche, T., Burgermeister, B., Scheuerecker, J., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.029 · Cited by 190
Progressive Brain Volume Loss During Adolescence in Childhood-Onset Schizophrenia
Sporn, A. L., GREENSTEIN, D. K., Gogtay, N., Jeffries, N. O., Lenane, M., Gochman, P., CLASEN, L. S., Blumenthal, J. D., Giedd, J. N., & Rapoport, J. L. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.12.2181 · Cited by 190
A neurobiological mapping of theory of mind
Abu-Akel, A. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00190-5 · Cited by 189
Cerebral grey, white matter and csf in never-medicated, first-episode schizophrenia
Chua, S. E., Cheung, C., Cheung, V., Tsang, J. T. K., Chen, E. Y. H., Wong, J. C. H., Cheung, J. P. Y., Yip, L., Tai, K.-S., John Suckling, A., et al. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.09.009 · Cited by 188
Michie, P. T., Innes-Brown, H., Todd, J., & Jablensky, A. V. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01379-3 · Cited by 187
Ross, L. A., Saint‐Amour, D., Leavitt, V. M., Molholm, S., Javitt, D. C., & Foxe, J. J. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.08.008 · Cited by 188
Campbell, L., Daly, E., Toal, F., Stevens, A., Azuma, R., Catani, M., Ng, V., van Amelsvoort, T., Chitnis, X. A., Cutter, W. J., et al. (2006) · Brain · doi:10.1093/brain/awl066 · Cited by 185
Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia
Théberge, J., Williamson, K. E., Aoyama, N., Drost, D. J., Manchanda, R., Malla, A. K., Northcott, S., Menon, R. S., Neufeld, R. W. J., Rajakumar, N., et al. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.033670 · Cited by 185
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Rieger, K., Hernandez, L. D., Bänninger, A., & Koenig, T. W. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00022 · Cited by 205
Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder
Irle, E., Lange, C., & Sachsse, U. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.004 · Cited by 182
Kawasaki, Y., Suzuki, M., Kherif, F., Takahashi, T., Zhou, S.-Y., Nakamura, K., Matsui, M., Sumiyoshi, T., Seto, H., & Kurachi, M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.08.018 · Cited by 180
McCarley, R. W., Salisbury, D. F., Hirayasu, Y., Yurgelun-Todd, D. A., Tohen, M. F., Zarate, C. A., Kikinis, R., Jolesz, F. A., & Shenton, M. E. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.4.321 · Cited by 182
Self-citationStrasser, H. C., Lilyestrom, J., Ashby, E. R., Honeycutt, N. A., Schretlen, D. J., Pulver, A. E., Hopkins, R. O., DePaulo, J. R., Potash, J. B., Schweizer, B. W., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.009 · Cited by 179
Classification of schizophrenia patients based on resting-state functional network connectivity
Arbabshirani, M. R., Kiehl, K. A., Pearlson, G. D., & Calhoun, V. D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00133 · Cited by 183
Antonova, E., Kumari, V., Morris, R. G., Halari, R., Anilkumar, A. P., Mehrotra, R., & Sharma, T. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.036 · Cited by 178
A voxel-based morphometric MRI study in female patients with borderline personality disorder
Rüsch, N., van Elst, L. T., Ludäscher, P., Wilke, M., Huppertz, H., Thiel, T., Schmahl, C. G., Bohus, M., Lieb, K., Heßlinger, B., et al. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00297-0 · Cited by 178
McIntosh, A. M., Job, D. E., Moorhead, T. W. J., Harrison, L. K., Forrester, K., Lawrie, S. M., & Johnstone, E. C. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.07.020 · Cited by 177
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Lee, S.-H., Kubicki, M., Asami, T., Seidman, L. J., Goldstein, J. M., Mesholam-Gately, R. I., McCarley, R. W., & Shenton, M. E. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.11.029 · Cited by 176
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Metadata
- Authors
- Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W.
- Affiliations
- Harvard University (US)
- Corresponding author
- Shenton, Martha E.
- McCarley, Robert W.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 49
- Issue
- 1-2
- Pages
- 1-52
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC2812015
- OpenAlex
- W1985994929
- Cited by
- 2,346
- References
- 480
- Citations by year
- 2026: 21 · 2025: 47 · 2024: 35 · 2023: 52 · 2022: 51 · 2021: 69 · 2020: 57 · 2019: 72 · 2018: 62 · 2017: 99 · 2016: 81 · 2015: 110 · 2014: 98 · 2013: 107 · 2012: 143
- FWCI
- 16.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- U.S. Department of Veterans Affairs
- University of Cambridge
- National Institute of Mental Health (MH-01110, MH-50740, MH40799, K02MH001110, R01MH050740, R01MH040799)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- schizophrenia, brain abnormalities
- MeSH terms
- Brain, Humans, Magnetic Resonance Imaging, Psychotic Disorders, Schizophrenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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