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A review of MRI findings in schizophrenia
Open accessAbstract
After more than 100 years of research, the neuropathology of schizophrenia remains unknown and this is despite the fact that both Kraepelin (1919/1971: Kraepelin, E., 1919/1971. Dementia praecox. Churchill Livingston Inc., New York) and Bleuler (1911/1950: Bleuler, E., 1911/1950. Dementia praecox or the group of schizophrenias. International Universities Press, New York), who first described 'dementia praecox' and the 'schizophrenias', were convinced that schizophrenia would ultimately be linked to an organic brain disorder. Alzheimer (1897: Alzheimer, A., 1897. Beitrage zur pathologischen anatomie der hirnrinde und zur anatomischen grundlage einiger psychosen. Monatsschrift fur Psychiarie und Neurologie. 2, 82-120) was the first to investigate the neuropathology of schizophrenia, though he went on to study more tractable brain diseases. The results of subsequent neuropathological studies were disappointing because of conflicting findings. Research interest thus waned and did not flourish again until 1976, following the pivotal computer assisted tomography (CT) finding of lateral ventricular enlargement in schizophrenia by Johnstone and colleagues. Since that time significant progress has been made in brain imaging, particularly with the advent of magnetic resonance imaging (MRI), beginning with the first MRI study of schizophrenia by Smith and coworkers in 1984 (Smith, R.C., Calderon, M., Ravichandran, G.K., et al. (1984). Nuclear magnetic resonance in schizophrenia: A preliminary study. Psychiatry Res. 12, 137-147). MR in vivo imaging of the brain now confirms brain abnormalities in schizophrenia. The 193 peer reviewed MRI studies reported in the current review span the period from 1988 to August, 2000. This 12 year period has witnessed a burgeoning of MRI studies and has led to more definitive findings of brain abnormalities in schizophrenia than any other time period in the history of schizophrenia research. Such progress in defining the neuropathology of schizophrenia is largely due to advances in in vivo MRI techniques. These advances have now led to the identification of a number of brain abnormalities in schizophrenia. Some of these abnormalities confirm earlier post-mortem findings, and most are small and subtle, rather than large, thus necessitating more advanced and accurate measurement tools. These findings include ventricular enlargement (80% of studies reviewed) and third ventricle enlargement (73% of studies reviewed). There is also preferential involvement of medial temporal lobe structures (74% of studies reviewed), which include the amygdala, hippocampus, and parahippocampal gyrus, and neocortical temporal lobe regions (superior temporal gyrus) (100% of studies reviewed). When gray and white matter of superior temporal gyrus was combined, 67% of studies reported abnormalities. There was also moderate evidence for frontal lobe abnormalities (59% of studies reviewed), particularly prefrontal gray matter and orbitofrontal regions. Similarly, there was moderate evidence for parietal lobe abnormalities (60% of studies reviewed), particularly of the inferior parietal lobule which includes both supramarginal and angular gyri. Additionally, there was strong to moderate evidence for subcortical abnormalities (i.e. cavum septi pellucidi-92% of studies reviewed, basal ganglia-68% of studies reviewed, corpus callosum-63% of studies reviewed, and thalamus-42% of studies reviewed), but more equivocal evidence for cerebellar abnormalities (31% of studies reviewed). The timing of such abnormalities has not yet been determined, although many are evident when a patient first becomes symptomatic. There is, however, also evidence that a subset of brain abnormalities may change over the course of the illness. The most parsimonious explanation is that some brain abnormalities are neurodevelopmental in origin but unfold later in development, thus setting the stage for the development of the symptoms of schizophrenia. Or there may be additional factors, such as stress or neurotoxicity, that occur during adolescence or early adulthood and are necessary for the development of schizophrenia, and may be associated with neurodegenerative changes. Importantly, as several different brain regions are involved in the neuropathology of schizophrenia, new models need to be developed and tested that explain neural circuitry abnormalities effecting brain regions not necessarily structurally proximal to each other but nonetheless functionally interrelated. (ABSTRACT TRUNCATED)
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“whereas adult-onset schizophrenia (the more typical form) is more strongly associated with deficits in later-maturing temporal and frontal regions (53–55) and is associated with selective abnormalities of the heteromodal regions (29).”
From Dynamic mapping of human cortical development during childhood through early adulthood (2004) · cites this paper as [53]
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“Schizophrenia is associated with loss of brain tissue, in particular in the frontal and temporal cortices as well as in some subcortical structures. 1,2”
From Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls. (2015) · cites this paper as [2]
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Cites
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Morphometric Tools for Landmark Data
Bookstein, F. L. (1992) · Cambridge University Press eBooks · doi:10.1017/cbo9780511573064 · Cited by 4,481
Dementia Praecox or the Group of Schizophrenias
(1951) · Journal of the American Medical Association · doi:10.1001/jama.1951.02920270079043 · Cited by 4,407
Le Bihan, D., Breton, E., Lallemand, D., Grenier, P., Cabanis, E., & Laval-Jeantet, M. (1986) · Radiology · doi:10.1148/radiology.161.2.3763909 · Cited by 3,912
Meta-analysis in social research
(1982) · Evaluation and Program Planning · doi:10.1016/0149-7189(82)90011-8 · Cited by 3,896
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072
Research works printed but not linked: 10
- Altshuler, 1998, Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: an MRI study demonstrating neuroanatomic specificity [letter], Arch. Gen. Psychiatry, 55, 663
- Anderson, 1998, Anatomy Browser: Java based interactive teaching tool for learning human neuroanatomy, RSNA Electronic Journal, 2, 50
- Gruzelier, 1991, Hemispheric imbalance: syndromes of schizophrenia, premorbid personality, and neurodevelopmental influences, vol. 5, 599
- Hecker, 1871, Die hebephrenic, Arch. Patholiche Anat. und fur Physiol. Klinische Medicin., 52, 394
- Hier, 1978, Autism-association with reversed cerebral asymmetry, Neurology, 28, 348
- LeMay, 1986, Leftright temporal region asymmetry in infants and children [letter], AJNR Am. J. Neuroradiol., 7, 974
- Scheibel, 1981, Disorientation of the hippocampal pyramidal cell and its processes in the schizophrenic patient, Biol. Psychiatry, 16, 101
- Shelton, 1986, X-ray computerized tomography studies in schizophrenia: a review and synthesis, vol. I, 207
- Shenton, 1996, Temporal lobe structural abnormalities in schizophrenia: a selective review and presentation of new MR findings, 51
- Shenton, 1997, A review of magnetic resonance imaging studies of brain abnormalities in schizophrenia, 297
Cited by
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Uhlhaas, P. J., & Singer, W. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2774 · Cited by 2,120
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Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020
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MOFFETT, J., Ross, B., Arun, P., Madhavarao, C. N., & Namboodiri, A. M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.12.003 · Cited by 1,443
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Scheid, T. L., & Brown, T. N. (2009) · Cited by 1,320
Schizophrenia as a Disorder of Neurodevelopment
Lewis, D. A., & Levitt, P. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142754 · Cited by 1,163
Honea, R., Crow, T. J., Passingham, D., & Mackay, C. E. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.12.2233 · Cited by 1,157
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106
Functional connectivity of human striatum: a resting state FMRI study
Di Martino, A., Scheres, A., Margulies, D. S., Kelly, A. M. C., Uddin, L. Q., Shehzad, Z., Biswal, B., Walters, J. R., Castellanos, F. X., & Milham, M. P. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn041 · Cited by 1,090
The neurodevelopmental model of schizophrenia: update 2005
Rapoport, J. L., Addington, A. M., Frangou, S., & Psych, M. R. C. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001642 · Cited by 993
Regionally Localized Thinning of the Cerebral Cortex in Schizophrenia
Kuperberg, G. R., Broome, M. R., McGuire, P. K., David, A. S., Eddy, M., Ozawa, F., Goff, D., West, W. C., Williams, S. C. R., van der Kouwe, A. J. W., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.878 · Cited by 843
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
the Alzheimer’s Disease Neuroimaging Initiative, E. C., Thompson, P. M., Stein, J. L., Medland, S. E., Hibar, D. P., Vasquez, A. A., Renteria, M. E., Toro, R., Jahanshad, N., Schumann, G., et al. (2014) · Brain Imaging and Behavior · doi:10.1007/s11682-013-9269-5 · Cited by 838
Steen, R. G., Mull, C., Mcclure, R., Hamer, R. M., & Lieberman, J. A. (2006) · British Journal of Psychiatry · doi:10.1192/bjp.188.6.510 · Cited by 832
Zhang, F., & O’Donnell, L. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815739-8.00007-9 · Cited by 869
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Lieberman, J. A. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.361 · Cited by 804
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Jones, C., Watson, D., & Fone, K. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01386.x · Cited by 771
Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia
Douaud, G., Smith, S. M., Jenkinson, M., Behrens, T. E. J., Johansen‐Berg, H., Vickers, J., James, S., Voets, N., Watkins, K. E., Matthews, P. M., et al. (2007) · Brain · doi:10.1093/brain/awm184 · Cited by 781
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Kubicki, M., McCarley, R., Westin, C.-F., Park, H.-J., Maier, S., Kikinis, R., Jolesz, F. A., & Shenton, M. E. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.05.005 · Cited by 769
Self-citationRegionally localized thinning of the cerebral cortex in schizophrenia
Kuperberg, G. R., Broome, M. R., McGuire, P. K., David, A. S., Eddy, M., Ozawa, F., GOFF, D. C., West, W. C., Williams, S., van der Kouwe, A. J. W., et al. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)81127-1 · Cited by 759
Decreased volume of left and total anterior insular lobule in schizophrenia
Makris, N., Goldstein, J. M., Kennedy, D. N., Hodge, S. M., Caviness, V. S., Faraone, S. V., Tsuang, M. T., & Seidman, L. J. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.11.020 · Cited by 788
Meta-analysis of diffusion tensor imaging studies in schizophrenia
Ellison-Wright, I., & Bullmore, E. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.11.021 · Cited by 715
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Wang, S., & Summers, R. M. (2012) · Medical Image Analysis · doi:10.1016/j.media.2012.02.005 · Cited by 727
The role of the cerebellum in schizophrenia
Andreasen, N. C., & Pierson, R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.003 · Cited by 669
Mitchell, K., & Johnson, M. K. (2009) · Psychological Bulletin · doi:10.1037/a0015849 · Cited by 712
Ellison-Wright, I., Glahn, D. C., Laird, A. R., Thelen, S. M., & Bullmore, E. T. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07101562 · Cited by 624
Allen, P., Larøi, F., McGuire, P. K., & Aleman, A. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.07.012 · Cited by 579
Pantelis, C. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi034 · Cited by 573
Anatomy of bipolar disorder and schizophrenia: A meta-analysis
Ellison-Wright, I., & Bullmore, E. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.12.022 · Cited by 565
Jovicich, J., Czanner, S., Han, X., Salat, D. H., van der Kouwe, A. J. W., Quinn, B. T., Pacheco, J., Albert, M., Killiany, R., & Blacker, D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.02.010 · Cited by 557
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Ho, B., Andreasen, N. C., Nopoulos, P., Arndt, S. V., Magnotta, V. A., & Flaum, M. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.585 · Cited by 536
Reichenberg, A., & Harvey, P. D. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.5.833 · Cited by 558
Meta-analysis, Database, and Meta-regression of 98 Structural Imaging Studies in Bipolar Disorder
Kempton, M. J., Geddes, J. R., Ettinger, U., Williams, S., & Grasby, P. M. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.9.1017 · Cited by 547
Rosenfield, S., & Mouzon, D. M. (2012) · Handbooks of sociology and social research · doi:10.1007/978-94-007-4276-5_14 · Cited by 592
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Lesh, T. A., Niendam, T. A., Minzenberg, M., & Carter, C. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.156 · Cited by 522
Onitsuka, T., Shenton, M. E., Salisbury, D. F., Dickey, C. C., Kasai, K., Toner, S. K., Frumin, M., Kikinis, R., Jolesz, F. A., & McCarley, R. W. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.9.1603 · Cited by 512
Self-citationOlabi, B., Ellison-Wright, I., McIntosh, A. M., Wood, S. J., Bullmore, E. T., & Lawrie, S. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.032 · Cited by 489
Barch, D. M., & Dowd, E. C. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq068 · Cited by 507
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Simpson, E. H., Kellendonk, C., & Kandel, E. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.014 · Cited by 478
Skudlarski, P., Jagannathan, K., Anderson, K., Stevens, M. C. G., Calhoun, V. D., Skudlarska, B. A., & Pearlson, G. D. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.035 · Cited by 476
Hubl, D., Koenig, T. W., Strik, W. K., Federspiel, A., Kreis, R., Boesch, C., Maier, S. E., Schroth, G., Lövblad, K., & Dierks, T. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.658 · Cited by 466
Cortical Thickness and Subcortical Volumes in Schizophrenia and Bipolar Disorder
Rimol, L. M., Hartberg, C. B., Nesvåg, R., Fennema‐Notestine, C., Hagler, D. J., Pung, C. J., Jennings, R. G., Haukvik, U. K., Lange, E., Nakstad, P., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.036 · Cited by 469
Uncinate Fasciculus Findings in Schizophrenia: A Magnetic Resonance Diffusion Tensor Imaging Study
Kubicki, M. R., Westin, C., Maier, S. E., Frumin, M., Nestor, P. G., Salisbury, D. F., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Shenton, M. E. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.813 · Cited by 454
Self-citationLodge, D., & Grace, A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2847-07.2007 · Cited by 475
Disrupted axonal fiber connectivity in schizophrenia
Zalesky, A., Fornito, A., Seal, M. L., Cocchi, L., Westin, C.-F., Bullmore, E. T., Egan, G. F., & Pantelis, C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.022 · Cited by 439
Dorph‐Petersen, K., Pierri, J. N., Perel, J. M., Sun, Z., Sampson, A. R., & Lewis, D. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300710 · Cited by 438
Collerton, D., Perry, E. K., & McKeith, I. G. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000130 · Cited by 447
The cognitive neuroscience of schizophrenia.
Barch, D. M. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143959 · Cited by 437
Suto, T., Fukuda, M., Ito, M., Uehara, T., & Mikuni, M. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.09.008 · Cited by 430
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Kubicki, M. R., Park, H., Westin, C., Nestor, P. G., Mulkern, R. V., Maier, S. E., Niznikiewicz, M. A., Connor, E. E., Levitt, J. J., Frumin, M., et al. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.03.026 · Cited by 433
Self-citationHikida, T., Jaaro-Peled, H., Seshadri, S., Oishi, K., Hookway, C., Kong, S., Wu, D., Xue, R., Andradé, M., Tankou, S. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704774104 · Cited by 424
D'Angelo, E., & Casali, S. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00116 · Cited by 407
The relationship between brain structure and neurocognition in schizophrenia: a selective review
Antonova, E., Sharma, T., Morris, R. G., & Kumari, V. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2003.12.002 · Cited by 427
MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders
Geuze, E., Vermetten, E., & Bremner, J. D. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001579 · Cited by 412
Schizophrenia, “Just the Facts”: What we know in 2008
Tandon, R., Keshavan, M. S., & Nasrallah, H. A. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.01.022 · Cited by 430
A review of multivariate methods for multimodal fusion of brain imaging data
Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, N. Q. U. O. S. A. T., Adalı, T., Yu, Q., Chen, J., & Calhoun, V. D. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.10.031 · Cited by 418
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Cahn, W., Pol, H. E. H., Lems, E. B. T. E., van Haren, N. E. M., Schnack, H. G., van der Linden, J. A., Schothorst, P. F., van Engeland, H., & Kahn, R. S. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.11.1002 · Cited by 398
Hippocampal changes associated with early-life adversity and vulnerability to depression
Rao, U., Chen, L.-A., Bidesi, A. S., Shad, M. U., Thomas, M. A., & Hammen, C. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.017 · Cited by 383
Salisbury, D. F., Kuroki, N., Kasai, K., Shenton, M. E., & McCarley, R. W. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.5.521 · Cited by 379
Self-citationXu, L., Groth, K. M., Pearlson, G. D., Schretlen, D. J., & Calhoun, V. D. (2008) · Human Brain Mapping · doi:10.1002/hbm.20540 · Cited by 383
Kubicki, M., Westin, C.-F., Nestor, P. G., Wible, C. G., Frumin, M., Maier, S. E., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Shenton, M. E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00419-0 · Cited by 376
Self-citationHulshoff Pol, H. E., & Kahn, R. S. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm168 · Cited by 364
Schobel, S., Lewandowski, N., Corcoran, C., Moore, H., Brown, T., Malaspina, D., & Small, S. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.115 · Cited by 384
Kasai, K., Shenton, M. E., Salisbury, D. F., Hirayasu, Y., Lee, C., Ciszewski, A. A., Yurgelun-Todd, D. A., Kikinis, R., Jolesz, F. A., & McCarley, R. W. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.156 · Cited by 365
Self-citationMoore, H., Jentsch, J., Ghajarnia, M., Geyer, M. A., & Grace, A. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.01.003 · Cited by 362
Fornito, A., Yücel, M., Patti, J., Wood, S. J., & Pantelis, C. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.12.011 · Cited by 359
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Narr, K. L., Bilder, R. M., Toga, A. W., Woods, R. P., Rex, D., Szeszko, P. R., Robinson, D. G., Sevy, S. M., Gunduz‐Bruce, H., Wang, Y.-P., et al. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh172 · Cited by 363
Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation?
MEYER, U., FELDON, J., & DAMMANN, O. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212c196 · Cited by 357
“One example is that autism has generally been associated with excessive brain growth (macrocephaly) involving thickening of cortex, increased gray and white matter, and lack of gray matter loss (41), whereas schizophrenia seems to be associated with microcephaly involving thinner cortical areas, reduced gray and white…”
Francks, C., Maegawa, S., Laurén, J., Abrahams, B. S., Velayos‐Baeza, A., Medland, S. E., Colella, S., Groszer, M., McAuley, E. Z., Caffrey, T. M., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002053 · Cited by 355
Voxel-Based Morphometric Analysis of Gray Matter in First Episode Schizophrenia
Kubicki, M. R. (2002) · NeuroImage · doi:10.1006/nimg.2002.1296 · Cited by 357
Review: Glutamate and dopamine dysregulation in schizophrenia — a synthesis and selective review
Stone, J. M., Morrison, P. D., & Pilowsky, L. S. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106073126 · Cited by 362
Schizophrenia, “just the facts”: What we know in 2008Part 3: Neurobiology
Keshavan, M. S., TANDON, R., Boutros, N. N., & Nasrallah, H. A. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.07.020 · Cited by 360
Teffer, K., & Semendeferi, K. (2012) · Progress in brain research · doi:10.1016/b978-0-444-53860-4.00009-x · Cited by 367
Cortical Volume, Surface Area, and Thickness in Schizophrenia and Bipolar Disorder
Rimol, L. M., Nesvåg, R., Hagler, D. J., Bergmann, Ø., Fennema‐Notestine, C., Hartberg, C. B., Haukvik, U. K., Lange, E., Pung, C. J., Server, A., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.026 · Cited by 340
Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings
Navari, S., & Dazzan, P. (2009) · Psychological Medicine · doi:10.1017/s0033291709005315 · Cited by 353
The Myth of Schizophrenia as a Progressive Brain Disease
Zipursky, R. B., Reilly, T. J., & Murray, R. M. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs135 · Cited by 336
Evidence of a dimensional relationship between schizotypy and schizophrenia: A systematic review
Nelson, M. T., Seal, M. L., Pantelis, C., & Phillips, L. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.004 · Cited by 334
Progressive Gray Matter Reduction of the Superior Temporal Gyrus During Transition to Psychosis
Takahashi, T., Wood, S. J., Yung, A. R., Soulsby, B., McGorry, P. D., Suzuki, M., Kawasaki, Y., Phillips, L., Velakoulis, D., & Pantelis, C. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.12 · Cited by 328
γ-Band Auditory Steady-State Responses Are Impaired in First Episode Psychosis
Spencer, K., Salisbury, D. F., Shenton, M. E., & McCarley, R. W. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.021 · Cited by 325
Self-citationChan, R. C. K., Di, X., McAlonan, G. M., & Gong, Q. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp073 · Cited by 330
On the other hand: including left-handers in cognitive neuroscience and neurogenetics
Willems, R. M., der Haegen, L. V., Fisher, S. E., & Francks, C. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3679 · Cited by 333
Chisholm, K., Lin, A. P., Abu-Akel, A. M., & Wood, S. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.012 · Cited by 347
What Do We Know About Neuropsychological Aspects Of Schizophrenia?
Palmer, B. W., Dawes, S. E., & Heaton, R. K. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9109-y · Cited by 339
Regional gray matter volume abnormalities in the at risk mental state.
Borgwardt, S., Riecher-Rössler, A., Dazzan, P., Chitnis, X., Aston, J., Drewe, M., Gschwandtner, U., Haller, S., Pflüger, M., Rechsteiner, E., et al. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.009 · Cited by 329
Structural connectomics in brain diseases
Griffa, A., Baumann, P., Thiran, J., & Hagmann, P. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.056 · Cited by 319
Link, B. G., & Phelan, J. C. (2012) · Handbooks of sociology and social research · doi:10.1007/978-94-007-4276-5_25 · Cited by 314
Neural circuits subserving behavioral flexibility and their relevance to schizophrenia
Floresco, S. B., Zhang, Y., & Enomoto, T. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.001 · Cited by 298
Progressive brain structural changes mapped as psychosis develops in ‘at risk’ individuals
Sun, D., Phillips, L., Velakoulis, D., Yung, A. R., McGorry, P. D., Wood, S. J., van Erp, T. G. M., Thompson, P. M., Toga, A. W., Cannon, T. D., et al. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.11.026 · Cited by 300
Holmes, A. J., Lee, P. H., Hollinshead, M. O., Bakst, L., Roffman, J. L., Smoller, J. W., & Buckner, R. L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2531-12.2012 · Cited by 293
“…bipolar disorder (Drevets et al., 1997; Phillips and Vieta, 2007; Price and Drevets, 2010; Savitz and Drevets, 2009a; Strakowski et al., 1999), schizophrenia (Benes, 2000; Koo et al., 2008; Shenton et al., 2001; Williams et al., 2004), and ADHD (Castellanos and Proal, 2012; Seidman et al., 2006)].”
BackgroundNeuroimaging predictors of transition to psychosis—A systematic review and meta-analysis
Smieskova, R., Fusar‐Poli, P., Allen, P., Bendfeldt, K., Stieglitz, R. D., Drewe, J., Radue, E. W., McGuire, P. K., Riecher‐Rössler, A., & Borgwardt, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.016 · Cited by 299
Apoptotic mechanisms and the synaptic pathology of schizophrenia
Glantz, L. A., Gilmore, J. H., Lieberman, J. A., & Jarskog, L. F. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.08.014 · Cited by 293
Santesteban-Echarri, O., Paino, M., Rice, S., González-Blanch, C., McGorry, P., Gleeson, J., & Alvarez-Jimenez, M. (2017) · Clinical Psychology Review · doi:10.1016/j.cpr.2017.09.007 · Cited by 268
Developmental Vitamin D3 deficiency alters the adult rat brain
Feron, F. P., Burne, T. H. J., Brown, J., Smith, E., McGrath, J. J., Mackay‐Sim, A., & Eyles, D. W. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2004.12.007 · Cited by 272
MR connectomics: Principles and challenges
Hagmann, P., Cammoun, L., Gigandet, X., Gerhard, S., Grant, P. E., Wedeen, V. J., Meuli, R. A., Thiran, J., Honey, C. J., & Sporns, O. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.01.014 · Cited by 276
Davatzikos, C. A., Shen, D. G., Gur, R. C., Wu, X., Liu, D., Yong Fan, A., Hughett, P., Turetsky, B. I., & Gur, R. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.11.1218 · Cited by 270
Giuliani, N. R., Calhoun, V. D., Pearlson, G. D., Francis, A., & Buchanan, R. W. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.08.019 · Cited by 269
Graph-based analysis of brain connectivity in schizophrenia
Olejarczyk, E., & Jernajczyk, W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188629 · Cited by 267
Takahashi, T., Cho, R. Y., Mizuno, T., Kikuchi, M., Murata, T., Takahashi, K., & Wada, Y. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.02.009 · Cited by 267
Regional specificity of hippocampal volume reductions in first-episode schizophrenia
Narr, K. L., Thompson, P. M., Szeszko, P. R., Robinson, D. G., Jang, S., Woods, R. P., Kim, S. H., Hayashi, K. M., Asunction, D., Toga, A. W., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.011 · Cited by 265
Metadata
- Authors
- Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W.
- Affiliations
- Harvard University (US)
- Corresponding author
- Shenton, Martha E.
- McCarley, Robert W.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 49
- Issue
- 1-2
- Pages
- 1-52
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC2812015
- OpenAlex
- W1985994929
- Cited by
- 2,346
- References
- 480
- Citations by year
- 2026: 21 · 2025: 47 · 2024: 35 · 2023: 52 · 2022: 51 · 2021: 69 · 2020: 57 · 2019: 72 · 2018: 62 · 2017: 99 · 2016: 81 · 2015: 110 · 2014: 98 · 2013: 107 · 2012: 143
- FWCI
- 16.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- U.S. Department of Veterans Affairs
- University of Cambridge
- National Institute of Mental Health (MH-01110, MH-50740, MH40799, K02MH001110, R01MH050740, R01MH040799)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- schizophrenia, brain abnormalities
- MeSH terms
- Brain, Humans, Magnetic Resonance Imaging, Psychotic Disorders, Schizophrenia
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