Antipsychotic Adherence Intervention for Veterans over 40 with Schizophrenia: Results of a Pilot Study
Open accessAbstract
This pilot study tested the feasibility, acceptability, and effect-sizes of a multimodal, individual intervention designed to optimize antipsychotic medication use in patients ≥40 years of age with schizophrenia or schizoaffective disorder. Methods: We randomized 40 patients into two groups: usual care (UC) or a nine-session, manualized, antipsychotic adherence intervention (AAI). the AAI attempted to improve adherence by combining three psychosocial techniques: a.education, b.skills training, and c.alliance building. Sessions employed a semi-structured format to facilitate open communication. the primary outcome was antipsychotic adherence at study end. We obtained qualitative data regarding patient preferences for the duration and modality for receiving the adherence intervention. Results: Compared to the UC group, a greater proportion of the AAI group was adherent post-intervention based on medication possession ratio, a commonly used measure of medication adherence (85% vs. 66.6%; OR=2.64), a difference that was statistically not significant. the entire AAI group reported that they intended to take medications, and 75% were satisfied with the intervention. Conclusions: The AAI was feasible and acceptable. Preliminary data on its effectiveness warrant a larger study. Qualitative data shows that patients prefer brief adherence interventions and accept telephone strategies.
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It is common for researchers to undertake a cross-sectional interview study with intervention deliverers and recipients and not to specify explicitly an approach or design when undertaking qualitative research in feasibility studies for trials.
“When undertaking qualitative research in feasibility studies for trials, it is common for researchers to undertake a cross-sectional interview study with intervention deliverers and recipients and not to specify explicitly an approach or design [12, 21, 22, 24].”
From Maximising the impact of qualitative research in feasibility studies for randomised controlled trials: guidance for researchers (2015) · cites this paper as [24]
Researchers commonly use qualitative research to address the acceptability and feasibility of the intervention or its perceived benefits.
“Researchers commonly use qualitative research to address the acceptability and feasibility of the intervention [10, 21–24] or its perceived benefits [11, 22].”
From Maximising the impact of qualitative research in feasibility studies for randomised controlled trials: guidance for researchers (2015) · cites this paper as [24]
Sample sizes for qualitative research in feasibility studies are usually small, typically between 5 and 20 individuals.
“In practice, sample sizes for qualitative research in feasibility studies are usually small (typically between 5 and 20 individuals [10, 12, 22–24]).”
From Maximising the impact of qualitative research in feasibility studies for randomised controlled trials: guidance for researchers (2015) · cites this paper as [24]
Feasibility studies for trials have often tended to rely solely upon interviews or focus group discussions with participants and intervention deliverers and have not drawn on the wider range of methods available.
“To date, feasibility studies for trials have often tended to rely solely upon interviews or focus group discussions with participants and intervention deliverers and have not drawn on the wider range of methods available [21–24].”
From Maximising the impact of qualitative research in feasibility studies for randomised controlled trials: guidance for researchers (2015) · cites this paper as [24]
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O’Cathain, A., Hoddinott, P., Lewin, S., Thomas, K. J., Young, B., Adamson, J., Jansen, Y. J., Mills, N., Moore, G., & Donovan, J. L. (2015) · Pilot and Feasibility Studies · doi:10.1186/s40814-015-0026-y · Cited by 458 · see citing works
- Authors
- Mittal, D., Owen, R., Lacro, J., Landes, R., Edlund, M., Valenstein, M., & Jeste, D.
- Affiliations
- Central Arkansas Veterans Healthcare System (US)
- VA San Diego Healthcare System (US)
- University of Arkansas for Medical Sciences (US)
- United States Department of Veterans Affairs (US)
- Venue
- European Psychiatry
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-01
- Volume
- 24
- Issue
- S1
- Pages
- S1171-S1171
- ISSN
- 0924-9338 (ISSN-L)
- 1778-3585
- PMC
- PMC2867602
- OpenAlex
- W3024050049
- Cited by
- 4
- References
- 30
- Citations by year
- 2021: 1 · 2016: 1 · 2015: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P30MH080002)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- antipsychotic adherence, medication adherence interventions, schizophrenia, schizoaffective disorder, older adults, veterans, psychosocial interventions, patient education, skills training, alliance building, feasibility and acceptability, telephone-delivered intervention, patient satisfaction
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