The DOI matches its Crossref record; 19 of the 20 references it cites were found in a registry or an index.
Oral probiotics can resolve urogenital infections
Open accessAbstract
We report the first clinical evidence that probiotic lactobacilli can be delivered to the vagina following oral intake. In 10 women with a history of recurrent yeast vaginitis, bacterial vaginosis (BV) and urinary tract infections, strains Lactobacillus rhamnosus GR-1 and Lactobacillus fermentum RC-14 suspended in skim milk and given twice daily for 14 days, were recovered from the vagina and identified by morphology and molecular typing within 1 week of commencement of therapy. In six cases of asymptomatic BV or intermediate BV (based upon Nugent scoring) was resolved within 1 week of therapy.
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“Evidence supports the translocation of gastrointestinal Lactobacillus strains to the vagina (gut-vagina axis), suggesting that oral probiotic intake may be directly linked with improved vaginal microbiota balance and local immune responses [55].”
From Women's health is a team effort: probiogenomics supports the development of a multi-species vaginal probiotic (2026) · cites this paper as [55]
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Cites
Nugent, R. P., Krohn, M. A., & Hillier, S. L. (1991) · Journal of Clinical Microbiology · doi:10.1128/jcm.29.2.297-301.1991 · Cited by 3,332
Guandalini, S., Pensabene, L., Zikri, M. A., Dias, J. A., Casali, L. G., Hoekstra, H., Kolaček, S., Massar, K., Mičetić‐Turk, D., Papadopoulou, A., et al. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00018 · Cited by 659
HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis
Sewankambo, N. K., Gray, R. H., Wawer, M. J., Paxton, L. A., McNairn, D., Wabwire‐Mangen, F., Serwadda, D., Li, C., Kiwanuka, N., Hillier, S. L., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01063-5 · Cited by 657
Gupta, K. (1999) · JAMA · doi:10.1001/jama.281.8.736 · Cited by 622
Hydrogen Peroxide--Producing Lactobacilli and Acquisition of Vaginal Infections
Hawes, S. E., Hillier, S. L., Benedetti, J., Stevens, C. E., Koutsky, L. A., Wölner‐Hanssen, P., & Holmes, K. K. (1996) · The Journal of Infectious Diseases · doi:10.1093/infdis/174.5.1058 · Cited by 525
The Scientific Basis for Probiotic Strains of Lactobacillus
Reid, G. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.9.3763-3766.1999 · Cited by 353
Self-citationHamilton‐Miller, J., Shah, S. A., & Winkler, J. T. (1999) · Public Health Nutrition · doi:10.1017/s1368980099000282 · Cited by 201
Heinemann, C., Vlieg, J. E. T. V. H., Janssen, D. B., Busscher, H. J., van der Mei, H. C., & Reid, G. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09282.x · Cited by 189
Self-citationSelection ofLactobacillusStrains for Urogenital Probiotic Applications
Reid, G., & Bruce, A. W. (2001) · The Journal of Infectious Diseases · doi:10.1086/318841 · Cited by 160
Self-citationDifferentiation of Lactobacillus Species by Molecular Typing
Wei, Z., Millsap, K. W., Bialkowska-Hobrzanska, H., & Reid, G. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.7.2418-2423.1998 · Cited by 157
Self-citationImplantation of Lactobacillus casei var rhamnosus into vagina
Reid, G., Millsap, K., & Bruce, A. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90543-6 · Cited by 89 · cited 2×
“Keywords: Probiotics; Urogenital ; Bacterial vaginosis ; Infection”
BackgroundMethodSelf-citationTreatment of Acute Diarrhea in the New Millennium
Guandalini, S. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200005000-00004 · Cited by 77
Reid, G. (2000) · International Dairy Journal · doi:10.1016/s0958-6946(00)00059-5 · Cited by 73
Self-citationHoward, J. C., Heinemann, C., Thatcher, B. J., Martin, B. M., Gan, B. S., & Reid, G. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.10.4396-4400.2000 · Cited by 54
Self-citationPotential Role of Lactobacilli as Prophylactic Agents Against Genital Pathogens
Barbés, C., & Boris, S. (1999) · AIDS Patient Care and STDs · doi:10.1089/apc.1999.13.747 · Cited by 53
Tackling bacterial vaginosis and HIV in developing countries
Mayaud, P. (1997) · The Lancet · doi:10.1016/s0140-6736(97)22034-9 · Cited by 35
Reid, G., & Seidenfeld, A. M. (1997) · PubMed · Cited by 23
Self-citationProbiotics in the treatment of diarrheal diseases
Reid, G. (2000) · Current Infectious Disease Reports · doi:10.1007/s11908-000-0092-y · Cited by 21
Self-citationBiotherapeutic Agents and Adult Diarrhea
Salminen, S., Isolauri, E., & Salminen, E. K. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-711-6_9 · Cited by 2
Research works printed but not linked: 2
- [4] Felmingham, D. (2000) Changing resistance patterns: European perspective. International Symposium on Trends and Perspectives in the Management of Urinary Tract Infection, Orlando, FL, March 10.
- Reid, 1995, Instillation of Lactobacillus and stimulation of indigenous organisms to prevent recurrence of urinary tract infections, Microecol. Ther., 23, 32
Cited by
Sorted by citations
Microbial biosurfactants production, applications and future potential
Banat, I. M., Franzetti, A., Gandolfi, I., Bestetti, G., Martinotti, M. G., Fracchia, L., Smyth, T. J., & Marchant, R. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2589-0 · Cited by 1,488
Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens
Servin, A. L. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.01.003 · Cited by 1,267
Probiotics: an overview of beneficial effects
Ouwehand, A. C., Salminen, S., & Isolauri, E. (2002) · Antonie van Leeuwenhoek · doi:10.1023/a:1020620607611 · Cited by 1,066
Biosurfactants: potential applications in medicine
Rodrigues, L. R., Banat, I. M., Teixeira, J. A., & Oliveira, R. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl024 · Cited by 923
Potential Uses of Probiotics in Clinical Practice
Reid, G., Jaß, J., Sebulsky, M. T., & McCormick, J. K. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.4.658-672.2003 · Cited by 918
Self-citation
Metadata
- Authors
- Reid, G., Bruce, A. W., Fraser, N., Heinemann, C., Owen, J., & Henning, B.
- Affiliations
- Western University (CA)
- Lawson Research Institute (CA)
- Corresponding author
- Reid, Gregor
- ORCID
- Reid, Gregor
- Venue
- FEMS Immunology & Medical Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02
- Volume
- 30
- Issue
- 1
- Pages
- 49-52
- ISSN
- 0928-8244 (ISSN-L)
- 1574-695X
- OpenAlex
- W2130187365
- Cited by
- 464
- References
- 20
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 14 · 2023: 32 · 2022: 19 · 2021: 24 · 2020: 15 · 2019: 19 · 2018: 12 · 2017: 22 · 2016: 22 · 2015: 14 · 2014: 27 · 2013: 33 · 2012: 24
- FWCI
- 30.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Immunology & Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Urology › Urinary Tract Infections Management
- Keywords
- oral probiotics, vaginal lactobacilli, Lactobacillus rhamnosus GR-1, bacterial vaginosis, urinary tract infection, urogenital infections, Nugent score
- MeSH terms
- Administration, Oral, Bacterial Infections, Female, Humans, Lactobacillus, Vagina, Probiotics, Female Urogenital Diseases
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