Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly (ethylene oxide-aspartate) block copolymer-adriamycin conjugates
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For polymeric micelles, longer PEO chains prolong circulation time and minimize reticuloendothelial system uptake.
“For polymeric micelles, the length of the PEO chains affects circulation time and uptake by the reticuloendothelial system, with longer chains prolonging circulation time and minimizing reticuloendothelial system uptake [38].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [38]
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“For polymeric micelles, the length of the PEO chains affects circulation time and uptake by the reticuloendothelial system, with longer chains prolonging circulation time and minimizing reticuloendothelial system uptake [38].”
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- Authors
- Kwon, G., Suwa, S., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K.
- Affiliations
- Tokyo University of Science (JP)
- Corresponding author
- Kataoka, K.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 1994-02
- Volume
- 29
- Issue
- 1-2
- Pages
- 17-23
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2013683557
- Cited by
- 409
- References
- 23
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 8 · 2017: 14 · 2016: 8 · 2015: 18 · 2014: 21 · 2013: 14 · 2012: 29
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- Funders
- Japan Research Foundation for Clinical Pharmacology
- Japan Society for the Promotion of Science
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- doxorubicin, tumor accumulation, circulation time, tissue distribution, colon adenocarcinoma, reticuloendothelial system, heart uptake, targeted drug delivery, core-shell micelles
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