Signal transduction by the TCR for antigen
Abstract
The past several years have seen the beginning of a shift in the way that TCR signal transduction is studied. Although many investigators continue to identify new molecules, particularly adaptor proteins, others have attempted to look at signaling events in a larger cellular context. Thus the identification of distinct formations of signaling molecules at junctions between T cells and antigen-presenting cells, the role of the cytoskeleton and the partitioning of molecules into specialized lipid subdomains have been the subjects of many publications. Such concepts are helping to assemble a blueprint of how the myriad adaptors and kinases fit together to effect T cell activation.
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The RhoH-Zap70 interaction is enhanced by additional expression of the Src family tyrosine kinase Lck.
“Interestingly, this interaction was enhanced by additional expression of a Src family tyrosine kinase, Lck, which is known to be an activator of Zap70 (see Figure 4) [65].”
From The small GTPase RhoH is an atypical regulator of haematopoietic cells (2008) · cites this paper as [65]
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- Authors
- Kane, L. P., Lin, J., & Weiss, A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Weiss, Arthur
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 12
- Issue
- 3
- Pages
- 242-249
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2121870374
- Cited by
- 498
- References
- 0
- Citations by year
- 2026: 8 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 15 · 2014: 7 · 2013: 14 · 2012: 6
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- T cell receptor signaling, antigen recognition, T cell activation, adaptor proteins, cytoskeleton, lipid rafts, signaling molecules, kinases
- MeSH terms
- Models, Structural, Protein-Tyrosine Kinases, Receptors, Antigen, T-Cell, T-Lymphocytes, Transcription Factors, Signal Transduction, Antigen Presentation, Models, Immunological
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