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Compliance in asthma
Open accessAbstract
Low rates of compliance with medication pose a major challenge to the effective management of most chronic diseases, including asthma. The high medical and social costs of non-compliance, and the apparent lack of effective methods for dealing with it, has stimulated renewed interest in this complex issue. Two broad categories of non-compliance have been identified, namely unintentional (or 'accidental') and intentional (or 'deliberate'). Unintentional non-compliance may result from poor doctor-patient communication or a lack of ability to follow advice. Intentional non-compliance occurs when the patient knows what is required but decides not to follow this to some degree. Healthcare professionals need to be aware of the various issues affecting compliance in all patients. The reasons for non-compliance are many and varied, and include factors such as complexity of the treatment regimen, administration route, patient beliefs about therapy and other psychological factors. Improvement in patient compliance with therapy will require better doctor-patient communication, improved patient education, the tailoring of therapy to the individual and possible novel strategies such as offering feedback to the patients on their level of compliance.
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“Concerns about asthma medicines and side-effects are known to add to the burden of living with asthma and lower levels of medication adherence [35].”
From A randomised controlled feasibility trial of Group Cognitive Behavioural Therapy for people with severe asthma (2017) · cites this paper as [35]
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Vecchioli-Scaldazza, C., Morosetti, C., Berouz, A., Giannubilo, W., & Ferrara, V. (2013) · Gynecologic and Obstetric Investigation · doi:10.1159/000350216 · Cited by 43
Lowe, P. J., Georgiou, P., & Canvin, J. (2014) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2014.12.002 · Cited by 41
Identifying Critical Errors: Addressing Inhaler Technique in the Context of Asthma Management
Bosnic-Anticevich, S. Z., Cvetkovski, B., Azzi, E., Srour, P., Tan, R. H., & Kritikos, V. S. (2018) · Pulmonary Therapy · doi:10.1007/s41030-018-0051-0 · Cited by 41
Role of inhaler competence and contrivance in “difficult asthma”
Everard, M. L. (2003) · Paediatric Respiratory Reviews · doi:10.1016/s1526-0542(03)00032-0 · Cited by 41
Jones, K. G., Bell, J. S., Fehrenbach, C., Pearce, L., Grimley, D., & McCarthy, T. P. (2002) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2002.tb11203.x · Cited by 41
Hillebregt, C. F., Vlonk, A., Bruijnzeels, M. A., van Schayck, O. C. P., & Chavannes, N. H. (2016) · International Journal of COPD · doi:10.2147/copd.s103998 · Cited by 39
Parental attitudes towards the management of asthma in ethnic minorities
Smeeton, N., Rona, R. J., Gregory, J. R., White, P. T., & Morgan, M. (2007) · Archives of Disease in Childhood · doi:10.1136/adc.2006.112037 · Cited by 39
Supporting chronic disease care quality
Sunyaev, A., & Chornyi, D. (2012) · Journal of Data and Information Quality · doi:10.1145/2184442.2184443 · Cited by 37
“Non-compliance with medical regimens prescribed by physicians is a major problem in chronic disease care [Cochrane et al. 1999; Vermeire et al. 2001] and patient diaries were shown to improve it [van Berge Henegouwen et al.”
BackgroundFactors associated with disparities in emergency department use among Latino children with asthma
CANINO, G. J., Garro, A. C., Alvarez, M., Colón‐Semidey, A., Esteban, C. A., Fritz, G. K., Koinis‐Mitchell, D., Kopel, S. J., Ortega, A. N., Seifer, R., et al. (2012) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2012.02.002 · Cited by 37
Wardlaw, A. J., Larivée, P., Eller, J., Cockcroft, D. W., Ghaly, L., & Harris, A. G. (2004) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61446-9 · Cited by 37
Fluticasone propionate in asthma: a long term dose comparison study
Verona, E. (2003) · Archives of Disease in Childhood · doi:10.1136/adc.88.6.503 · Cited by 37
Time and Risk Preferences and the Use of Asthma Controller Medication
Brandt, S., & Dickinson, B. J. (2013) · PEDIATRICS · doi:10.1542/peds.2011-2982 · Cited by 36
A preliminary investigation of the effectiveness of a sleep apnea education program
Smith, S. S., Lang, C. P., Sullivan, K. A., & Warren, J. (2004) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(03)00545-2 · Cited by 35
“, insulin-dependent diabetes [12, 13] and asthma [14,15]), such factors need to be examined in apnea education programs.”
BackgroundKuna, P., Creemers, J. P. H. M., Vondra, V., Black, P., Lindqvist, A. E., Nihlén, U., & Vogelmeier, C. F. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.03.016 · Cited by 35
Yorke, J., Adair, P., Doyle, A.-M., Dubrow-Marshall, L., Fleming, S., Holmes, L., Menzies-Gow, A., Niven, R., Pilling, M., & Shuldham, C. (2017) · Journal of Asthma · doi:10.1080/02770903.2016.1229335 · Cited by 34
“Concerns about asthma medicines and side-effects are known to add to the burden of living with asthma and lower levels of medication adherence [35].”
Regional variation and adherence to guidelines for drug treatment of asthma
Arnlind, M. H., Wettermark, B., Nokela, M., Hjemdahl, P., Rehnberg, C., & Jonsson, E. W. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-009-0731-7 · Cited by 33
“Previous studies have shown that longitudinal data on purchases of pharmaceuticals may contribute to the evaluation of patient compliance [11, 15, 60], but patient compliance with dispensed medications was beyond the scope of the present investigation.”
BackgroundRecent educational interventions for improvement of asthma medication adherence
Axelsson, M., & Lötvall, J. O. (2012) · Asia Pacific Allergy · doi:10.5415/apallergy.2012.2.1.67 · Cited by 32
“These perceptions and beliefs could result in so called intentional nonadherence, which is a result of a person’s conscious decision to deviate from the recommended treatment, for instance by underor overusing the medication or by prematurely terminating the treatment [14, 15].”
BackgroundNormativa para el asma de control difícil
-SEPAR, Á. D. A. (2005) · Archivos de Bronconeumología · doi:10.1157/13078654 · Cited by 32
Poor adherence to self-medication instructions in children with asthma and their parents
Colland, V. T., van Essen‐Zandvliet, L. E. M., Lans, C., Denteneer, A., Westers, P., & Brackel, H. (2004) · Patient Education and Counseling · doi:10.1016/j.pec.2003.04.010 · Cited by 31
Everard, M. L. (2000) · Thorax · doi:10.1136/thorax.55.10.811 · Cited by 31
Kennedy, S., Stone, A., & Rachelefsky, G. S. (2003) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63613-7 · Cited by 31
Spanish Asthma Patients’ Beliefs About Health and Medicines: Validation of 2 Questionnaires
Tordera, M. P., Moragón, E. M. M., Belloch, A., Bayo, A. L., & Císcar, C. P. (2009) · Archivos de Bronconeumología · doi:10.1016/s1579-2129(09)72151-2 · Cited by 30
Once-daily evening administration of mometasone furoate in asthma treatment initiation
Bensch, G. W., Prenner, B. M., Berkowitz, R. B., Galant, S. P., Ramsdell, J., & Lutsky, B. N. (2006) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63547-8 · Cited by 30
Cangelosi, M. J., Ortendahl, J. D., Meckley, L. M., Bentley, T. G. K., Anene, A. M., Shriner, K., & Fox, J. (2014) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/14737167.2015.978292 · Cited by 29
“Researchers have called for novel strategies and interventions to address severe persistent asthma patients who continue to experience exacerbations despite treatment with what is considered optimal pharmacological therapy [2–4].”
BackgroundInterference of psychological factors in difficult-to-control asthma
Halimi, L., Vachier, I., Varrin, M., Godard, P., Pithon, G., & Chanez, P. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.03.036 · Cited by 29
Self-citationKatsara, M., Donnelly, D., Iqbal, S., Elliott, T., & Everard, M. L. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.01.012 · Cited by 29
“Indeed, in one large study physicians were found to greatly over estimate compliance and physician assessment was found to be less reliable than either canister weighing or patient completed questionnaires, both of which significantly over-estimated compliance.(13) Personal characteristics provide few immediate clues…”
BackgroundEffects of treatment with mometasone furoate dry powder inhaler in children with persistent asthma
Berger, W. E., Milgrom, H., Chervinsky, P., Noonan, M. J., Weinstein, S. F., Lutsky, B. N., & Staudinger, H. W. (2006) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61099-x · Cited by 29
The role of leukotriene receptor antagonists in the treatment of chronic asthma in childhood
Warner, J. O. (2001) · Allergy · doi:10.1034/j.1398-9995.2001.00005.x · Cited by 28
“Because compliance is an important factor affecting the success of anti-asthma therapy (13, 19) these findings, coupled with frequently poor inhaler technique among children, may explain the difficulties faced by clinicians in ensuring adherence to their instructions for administering inhaled corticosteroids.”
Background
Metadata
- Authors
- Cochrane, G. M., Horne, R., & Chanez, P.
- Affiliations
- St Thomas' Hospital (GB)
- University of Brighton (GB)
- Hôpital Arnaud de Villeneuve (FR)
- ORCID
- Venue
- Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 93
- Issue
- 11
- Pages
- 763-769
- ISSN
- 0954-6111 (ISSN-L)
- OpenAlex
- W2016277634
- Cited by
- 246
- References
- 47
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 2 · 2014: 12 · 2013: 8 · 2012: 12
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
- Keywords
- medication adherence, asthma, non-compliance, physician-patient communication, patient education, psychological factors
- MeSH terms
- Asthma, Drug Administration Schedule, Humans, Patient Compliance, Treatment Refusal, Anti-Asthmatic Agents
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