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SNAREs and NSF in targeted membrane fusion
Open accessAbstract
A major current issue in vesicle trafficking is whether NSF (N-ethylmaleimide-sensitive factor) and alpha-SNAP (alpha-soluble NSF attachment protein) are required prior to SNARE (SNAP receptor) complex formation to allow vesicle docking, or after docking at a step close to membrane fusion. Recent studies of yeast vacuolar fusion indicated that the requirement for ATP, NSF and alpha-SNAP could be completely satisfied prior to SNARE docking complex assembly; however, the universality of a predocking role for these factors remains to be established. The vacuolar fusion system has also been used to directly demonstrate a requirement for SNARE proteins on both fusing membranes, verifying a central postulate of current fusion models.
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Ravichandran, V., Chawla, A., & Roche, P. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13300 · Cited by 354
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Metadata
- Authors
- Hay, J. C., & Scheller, R. H.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 9
- Issue
- 4
- Pages
- 505-512
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2005873851
- Cited by
- 297
- References
- 1
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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