Signalling through the insulin receptor

Whitehead, Jonathan P; Clark, Sharon F; Ursø, Birgitte; James, David E

doi:10.1016/s0955-0674(99)00079-4

Cited by 130Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Signalling through the insulin receptor

Whitehead, Jonathan P, Clark, Sharon F, Ursø, Birgitte, James, David E·2000·Current Opinion in Cell Biology

DOI 10.1016/s0955-0674(99)00079-4

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Abstract

The insulin receptor substrates function at the heart of the insulin signalling network. It has recently become apparent that the intracellular localisation of these molecules is regulated in a precise manner that is critical for both the generation and the termination of the insulin signal. Some insulin receptor substrate isoforms appear to be associated with an insoluble matrix that resembles the cytoskeleton. When inappropriately dissociated from this matrix the signalling network collapses concomitant with loss of insulin sensitivity.

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From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [140]
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From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [140]
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From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [140]

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Trauma and Hemorrhage-Induced Acute Hepatic Insulin Resistance: Dominant Role of Tumor Necrosis Factor-α
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Retracted
Bitter melon triterpenes work as insulin sensitizers and insulin substitutes in insulin-resistant cells
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Platelet-Derived Growth Factor (PDGF) Stimulates Glucose Transport in 3T3-L1 Adipocytes Overexpressing PDGF Receptor by a Pathway Independent of Insulin Receptor Substrates
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Mechanisms of Hemorrhage-Induced Hepatic Insulin Resistance: Role of Tumor Necrosis Factor-α
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The Exocytotic Trafficking of TC10 Occurs through both Classical and Nonclassical Secretory Transport Pathways in 3T3L1 Adipocytes
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Insect Neuropeptide and Peptide Hormone Receptors: Current Knowledge and Future Directions
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Conservatism of the Insulin Signaling System in Evolution of Invertebrate and Vertebrate Animals
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Pleckstrin Homology and Phosphotyrosine-binding Domain-dependent Membrane Association and Tyrosine Phosphorylation of Dok-4, an Inhibitory Adapter Molecule Expressed in Epithelial Cells
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Dose- and time-dependent effects of 17beta-oestradiol on insulin sensitivity in insulin-dependent tissues of rat: implications of IRS-1
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Role of Rab5 in insulin receptor-mediated endocytosis and signaling
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Constituents of the stem of Cucurbita moschata exhibit antidiabetic activities through multiple mechanisms
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The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin
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G Protein-coupled Receptor-induced Sensitization of Phospholipase C Stimulation by Receptor Tyrosine Kinases
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Insulin inhibits voltage-dependent calcium influx into rod photoreceptors
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Diabetes: The importance of the liver
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Focal adhesion kinase and Src mediate integrin regulation of insulin receptor phosphorylation
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Lipid kinases play crucial and multiple roles in membrane trafficking and signaling.
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Pyruvate dehydrogenase kinase 4 (PDK4) could be involved in a regulatory role in apoptosis and a link between apoptosis and insulin resistance
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Changes of DNA Methylation Pattern in Metabolic Pathways Induced by High-Carbohydrate Diet Contribute to Hyperglycemia and Fat Deposition in Grass Carp (Ctenopharyngodon idellus)
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Lipid-Induced Insulin Resistance in the Liver
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Pulling Strings Below the Surface: Hormone Receptor Signaling Through Inhibition of Protein Tyrosine Phosphatases
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Increasing neutrophil F‐actin corrects CD11b exposure in Type 2 diabetes
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Pretreatment with FK506 up-regulates insulin receptors in regenerating rat liver
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Light Regulation of the Insulin Receptor in the Retina
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Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles
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The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity
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Potentiation of Mitogenic Activity of Platelet‐Derived Growth Factor by Physiological Concentrations of Insulin via the MAP Kinase Cascade in Rat A10 Vascular Smooth Muscle Cells
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Effect of fetal dexamethasone exposure on the development of adult insulin sensitivity in a rat model
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Reduced volume-regulated outwardly rectifying anion channel activity in ventricular myocyte of type 1 diabetic mice
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Comparative analysis of tryptophan oxygenase activity and glucocorticoid receptor under the influence of insulin
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83. Abnormal Insulin Sensitivity Persists up to Three Years in Pediatric Patients Post Burn
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Cloning, chromosomal localization, SNP detection and association analysis of the porcine IRS-1 gene
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MicroarrayAnalysis of Altered Gene Expression in Kidneys of Adult Spontaneously Hypertensive Rats
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Regulation of Intermediatory Metabolism During Fasting and Feeding
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DRUG TARGETS: MOLECULAR MECHANISMS OF DRUG ACTION
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Alterations in Energy Metabolism, Mitochondrial Function and Redox Homeostasis in GK Diabetic Rat Tissues Treated with Aspirin
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Molecular mechanisms of insulin signaling
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Authors: Whitehead, J. P., Clark, S. F., Ursø, B., & James, D. E.
Affiliations: The University of Queensland (AU)
University of Copenhagen (DK)
Corresponding author: Whitehead, Jonathan P
Clark, Sharon F
Ursø, Birgitte
James, David E
ORCID: Whitehead, Jonathan P
James, David E
Venue: Current Opinion in Cell Biology
Publisher: Elsevier BV
Published: 2000-04
Volume: 12
Issue: 2
Pages: 222-228
ISSN: 0955-0674 (ISSN-L)
DOI: 10.1016/s0955-0674(99)00079-4
OpenAlex: W2049761828
Cited by: 130
References: 73
Citations by year: 2024: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 9 · 2014: 4 · 2013: 2 · 2012: 3
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: insulin receptor, insulin receptor substrate, insulin signaling, signal termination, insulin sensitivity, subcellular localization
MeSH terms: Animals, Insulin Resistance, Phosphoproteins, Receptor, Insulin, Signal Transduction, Insulin Receptor Substrate Proteins

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