Cited by 130Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

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Signalling through the insulin receptor

Whitehead, Jonathan P, Clark, Sharon F, Ursø, Birgitte, James, David E·2000·Current Opinion in Cell Biology

DOI 10.1016/s0955-0674(99)00079-4

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Abstract

The insulin receptor substrates function at the heart of the insulin signalling network. It has recently become apparent that the intracellular localisation of these molecules is regulated in a precise manner that is critical for both the generation and the termination of the insulin signal. Some insulin receptor substrate isoforms appear to be associated with an insoluble matrix that resembles the cytoskeleton. When inappropriately dissociated from this matrix the signalling network collapses concomitant with loss of insulin sensitivity.

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Authors: Whitehead, J. P., Clark, S. F., Ursø, B., & James, D. E.
Affiliations: The University of Queensland (AU)
University of Copenhagen (DK)
Corresponding author: Whitehead, Jonathan P
Clark, Sharon F
Ursø, Birgitte
James, David E
ORCID: Whitehead, Jonathan P
James, David E
Venue: Current Opinion in Cell Biology
Publisher: Elsevier BV
Published: 2000-04
Volume: 12
Issue: 2
Pages: 222-228
ISSN: 0955-0674 (ISSN-L)
DOI: 10.1016/s0955-0674(99)00079-4
OpenAlex: W2049761828
Cited by: 130
References: 73
Citations by year: 2024: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 9 · 2014: 4 · 2013: 2 · 2012: 3
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: insulin receptor, insulin receptor substrate, insulin signaling, signal termination, insulin sensitivity, subcellular localization
MeSH terms: Animals, Insulin Resistance, Phosphoproteins, Receptor, Insulin, Signal Transduction, Insulin Receptor Substrate Proteins

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