Signalling through the insulin receptor

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250

Disruption of IRS-2 causes type 2 diabetes in mice

Withers, D. J., Gutierrez, J. S., Towery, H. H., Burks, D. J., Ren, J., Previs, S. F., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,775

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

Araki, E., Lipes, M. A., Patti, M.-E., Brüning, J. C., Haag III, B., Johnson, R. S., & Kahn, C. R. (1994) · Nature · doi:10.1038/372186a0 · Cited by 1,252

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

Tamemoto, H., Kadowaki, T., Tobe, K., Yagi, T., Sakura, H., Hayakawa, T., Terauchi, Y., Ueki, K., Kaburagi, Y., Satoh, S., et al. (1994) · Nature · doi:10.1038/372182a0 · Cited by 1,081

Role of Translocation in the Activation and Function of Protein Kinase B

Andjelkovic, M., Alessi, D. R., Meier, R., Fernandez, A., Lamb, N. J. C., Frech, M., Cron, P., Cohen, P., Lucocq, J. M., & Hemmings, B. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31515 · Cited by 1,051

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

SHEPHERD, P. R., WITHERS, D. J., & SIDDLE, K. (1998) · Biochemical Journal · doi:10.1042/bj3330471 · Cited by 953

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

Böhni, R., Riesgo‐Escovar, J. R., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B. F., Beckingham, K., & Hafen, E. (1999) · Cell · doi:10.1016/s0092-8674(00)80799-0 · Cited by 840

Mechanism of activation and function of protein kinase B

Alessi, D. R., & Cohen, P. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80062-2 · Cited by 739

The IRS-signalling system: A network of docking proteins that mediate insulin action

White, M. F. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5647-3_1 · Cited by 666

Pathogenesis of type 2 diabetes mellitus

DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342

The protein tyrosine kinase family of the human genome

Robinson, D. R., Wu, Y., & Lin, S. (2000) · Oncogene · doi:10.1038/sj.onc.1203957 · Cited by 1,179

Pathogenesis of insulin resistance in skeletal muscle

Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670

Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo

Ring, D. B., Johnson, K. W., Henriksen, E. J., Nuss, J. M., Goff, D., Kinnick, T. R., Ma, S. T., Reeder, J. W., Samuels, I., Slabiak, T., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.3.588 · Cited by 532

Crk family adaptors–signalling complex formation and biological roles

Feller, S. M. (2001) · Oncogene · doi:10.1038/sj.onc.1204779 · Cited by 468

Insulin promotes rapid delivery of N -methyl- d - aspartate receptors to the cell surface by exocytosis

Skeberdis, V. A., Lan, J.-Y., Zheng, X., Zukin, R. S., & Bennett, M. V. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051634698 · Cited by 303

Axl is essential for VEGF‐A‐dependent activation of PI3K/Akt

Ruan, G.-X., & Kazlauskas, A. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.21 · Cited by 229

Insulin-related peptides and their conserved signal transduction pathway

Claeys, I., Simonet, G., Poels, J., Loy, T. V., Vercammen, L., LOOF, A. D., & Broeck, J. V. (2002) · Peptides · doi:10.1016/s0196-9781(01)00666-0 · Cited by 207

Mitochondrial dysfunction and complications associated with diabetes

Blake, R., & Trounce, I. A. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.11.007 · Cited by 190

Insulin and Sterol-regulatory Element-binding Protein-1c (SREBP-1C) Regulation of Gene Expression in 3T3-L1 Adipocytes

Lay, S. L., Lefrère, I., Trautwein, C., Dugail, I., & Krief, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203913200 · Cited by 172

Glucagon-Like Peptide-1 Gene Therapy in Obese Diabetic Mice Results in Long-Term Cure of Diabetes by Improving Insulin Sensitivity and Reducing Hepatic Gluconeogenesis

Lee, Y.-S., Shin, S., Shigihara, T., Hahm, E., Liu, M.-J., Han, J., Yoon, J.-W., & Jun, H.-S. (2007) · Diabetes · doi:10.2337/db06-1182 · Cited by 158

Persistent impaired glucose metabolism in a zebrafish hyperglycemia model

Capiotti, K. M., Antonioli, R., Kist, L. W., Bogo, M. R., Bonan, C. D., & da Silva, R. S. (2014) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2014.03.005 · Cited by 161

Regulation of phospholipase C γ isoforms in haematopoietic cells

Wilde, J. I., & Watson, S. P. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(01)00191-7 · Cited by 149

Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells

Yu, W., Chen, Z., Zhang, J., Zhang, L., Hui, K., Huang, L., Peng, Y., Zhang, X., Shu-nong, L., Lahn, B. T., et al. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9661-9 · Cited by 131

Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination

Papaconstantinou, J. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.11.025 · Cited by 127

The T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase

Genot, E. M., Arrieumerlou, C., Ku, G., Burgering, B. M. T., Weiss, A., & Kramer, I. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5469-5478.2000 · Cited by 121

Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation

Sun, L., Liu, L., Yang, X., & Wu, Z. (2004) · Journal of Cell Science · doi:10.1242/jcs.01142 · Cited by 119

Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo

Lorén, C. E., Scully, A. L., Grabbe, C., Edeen, P. T., Thomas, J. B., McKeown, M., Hunter, T. R., & Palmer, R. H. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00440.x · Cited by 111

Surfing the insulin signaling web

OBBERGHEN, E. V., Baron, V. T., Delahaye, L., Emanuelli, B., Filippa, N., Giorgetti‐Peraldi, S., Lebrun, P., Mothe‐Satney, I., Peraldi, P., Rocchi, S., et al. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00896.x · Cited by 111

In Vivo Phosphorylation of Insulin Receptor Substrate 1 at Serine 789 by a Novel Serine Kinase in Insulin-resistant Rodents

Qiao, L.-Y., Zhande, R., Jetton, T. L., Zhou, G., & Sun, X. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201494200 · Cited by 104

High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1

Reynoso‐Camacho, R., Salgado, L. M., & Calderón, V. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0298-2_22 · Cited by 96

Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse

Hsieh, C.-C., DeFord, J. H., Flurkey, K., Harrison, D. E., & Papaconstantinou, J. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00037-4 · Cited by 93

A newly synthetic chromium complex – chromium(phenylalanine)3 improves insulin responsiveness and reduces whole body glucose tolerance

Yang, X., Palanichamy, K., Ontko, A. C., Rao, M. N. A., Fang, C. X., Ren, J. T., & Sreejayan, N. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.01.049 · Cited by 87

Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the level of phosphorylation of IRS1 in type 2 diabetes

Danielsson, A., Öst, A., Lystedt, E., Kjølhede, P., Gustavsson, J., Nyström, F. H., & Strålfors, P. (2004) · FEBS Journal · doi:10.1111/j.1432-1033.2004.04396.x · Cited by 85

Insulin enhances the expression of the endothelial nitric oxide synthase in native endothelial cells: a dual role for Akt and AP-1

Fißlthaler, B., Benzing, T. R., Busse, R., & Fleming, I. (2003) · Nitric Oxide · doi:10.1016/s1089-8603(03)00042-9 · Cited by 82

Trpc1 Ion Channel Modulates Phosphatidylinositol 3-Kinase/Akt Pathway during Myoblast Differentiation and Muscle Regeneration

Zanou, N., Schakman, O., Louis, P., Rüegg, U. T., Dietrich, A., Birnbaumer, L., & Gailly, P. L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.341784 · Cited by 81

Epinephrine inhibits insulin-stimulated muscle glucose transport

Hunt, D. G., & Ivy, J. L. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00445.2002 · Cited by 82

Insulin Resistance the Link between T2DM and CVD: Basic Mechanisms and Clinical Implications

Abdul‐Ghani, M. A., Jayyousi, A., DeFronzo, R. A., Asaad, N., & Suwaidi, J. M. S. A. (2017) · Current Vascular Pharmacology · doi:10.2174/1570161115666171010115119 · Cited by 79

Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm

Hsieh, C.-C., DeFord, J. H., Flurkey, K., Harrison, D. E., & Papaconstantinou, J. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00036-2 · Cited by 75

High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1

Reynoso‐Camacho, R., Salgado, L. M., & Calderón, V. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1023423005187 · Cited by 74

Robust optimization of SVM hyperparameters in the classification of bioactive compounds

Czarnecki, W. M., Podlewska, S., & Bojarski, A. J. (2015) · Journal of Cheminformatics · doi:10.1186/s13321-015-0088-0 · Cited by 68

Depletion of Mitochondrial DNA Causes Impaired Glucose Utilization and Insulin Resistance in L6 GLUT4myc Myocytes

Park, S. Y., Choi, G. H., Choi, H. I., Ryu, J., Jung, C. Y., & Lee, W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409399200 · Cited by 61

Aloe emodin glycosides stimulates glucose transport and glycogen storage through PI3K dependent mechanism in L6 myotubes and inhibits adipocyte differentiation in 3T3L1 adipocytes

Anand, S., Muthusamy, V., Sujatha, S., Sangeetha, K. N., Raja, R., Selvaraju, S., Devi, N., & Lakshmi, B. S. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.06.004 · Cited by 60

Naphthalenemethyl ester derivative of dihydroxyhydrocinnamic acid, a component of cinnamon, increases glucose disposal by enhancing translocation of glucose transporter 4

Kim, W. I., Khil, L., Clark, R., Bok, S. H., Kim, E. E., Lee, S., Jun, H., & Yoon, J. (2006) · Diabetologia · doi:10.1007/s00125-006-0373-6 · Cited by 60

The Pleckstrin Homology (PH) Domain-Interacting Protein Couples the Insulin Receptor Substrate 1 PH Domain to Insulin Signaling Pathways Leading to Mitogenesis and GLUT4 Translocation

Farhang-Fallah, J., Randhawa, V. K., Nimnual, A. S., Klip, A., Bar‐Sagi, D., & Rozakis-Adcock, M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.20.7325-7336.2002 · Cited by 58

Trauma and Hemorrhage-Induced Acute Hepatic Insulin Resistance: Dominant Role of Tumor Necrosis Factor-α

Xu, J. H., Kim, H. T., Ma, Y., Ling, Z., Zhai, L., Kokorina, N. A., Wang, P., & Messina, J. L. (2008) · Endocrinology · doi:10.1210/en.2007-0922 · Cited by 51

Bitter melon triterpenes work as insulin sensitizers and insulin substitutes in insulin-resistant cells

Chang, C., Chou, C., Liao, M., Chen, T.-M., Cheng, C.-H., Anggriani, R., Tsai, C.-P., Tseng, H.-I., & Cheng, H. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2014.12.050 · Cited by 49

Tetramethylpyrazine prevents diabetes by activating PI3K/Akt/GLUT-4 signalling in animal model of type-2 diabetes

Rai, U., Kosuru, R., Prakash, S., Singh, S. P., Birla, H., Tiwari, V. K., & Singh, S. K. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116836 · Cited by 46

NO Attenuates Insulin Signaling and Motility in Aortic Smooth Muscle Cells via Protein Tyrosine Phosphatase 1B–Mediated Mechanism

Sreejayan, N., Lin, Y., & Hassid, A. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000020550.65963.e9 · Cited by 46

Autonomic Blockade Improves Insulin Sensitivity in Obese Subjects

Gamboa, A., Okamoto, L. E., Arnold, A. C., Figueroa, R. A., Diedrich, A., Raj, S. R., Paranjape, S. Y., Farley, G., Abumrad, N., & Biaggioni, I. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03738 · Cited by 45

A novel view on the mechanisms of action of insulin and other insulin superfamily peptides: involvement of adenylyl cyclase signaling system

Pertseva, M. N., Shpakov, A. O., Плеснева, С. А., & Kuznetsova, L. A. (2003) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(02)00160-4 · Cited by 45

Platelet-Derived Growth Factor (PDGF) Stimulates Glucose Transport in 3T3-L1 Adipocytes Overexpressing PDGF Receptor by a Pathway Independent of Insulin Receptor Substrates

Whiteman, E. L., Chen, J. J., & Birnbaum, M. J. (2003) · Endocrinology · doi:10.1210/en.2003-0480 · Cited by 44

The Exocytotic Trafficking of TC10 Occurs through both Classical and Nonclassical Secretory Transport Pathways in 3T3L1 Adipocytes

Watson, R. T., Furukawa, M., Chiang, S.-H., Boeglin, D., Kanzaki, M., Saltiel, A. R., & Pessin, J. E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.961-974.2003 · Cited by 43

Insect Neuropeptide and Peptide Hormone Receptors: Current Knowledge and Future Directions

Claeys, I., Poels, J., Simonet, G., Franssens, V., Loy, T. V., Hiel, M. B. V., Breugelmans, B., & Broeck, J. V. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)73007-7 · Cited by 43

Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60 %-partial pancreatectomy rats

Jetton, T. L., Liu, Y. Q., Trotman, W., Sun, X., Leahy, J. L., & Nevin, P. W. (2001) · Diabetologia · doi:10.1007/s001250100011 · Cited by 42

Growth effects of insulin and insulin analogues

SANDOW, J. (2009) · Archives of Physiology and Biochemistry · doi:10.1080/13813450902835690 · Cited by 40

Differential sensitivity to apoptosis between the human small and large intestinal mucosae: Linkage with segment‐specific regulation of Bcl‐2 homologs and involvement of signaling pathways*

Gauthier, R., Laprise, P., Cardin, É., Harnois, C., Plourde, A., Reed, J. C., Vézina, A., & Vachon, P. H. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1172 · Cited by 39

Conservatism of the Insulin Signaling System in Evolution of Invertebrate and Vertebrate Animals

Pertseva, M. N., & Shpakov, A. O. (2002) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1023/a:1022008932029 · Cited by 35

Pleckstrin Homology and Phosphotyrosine-binding Domain-dependent Membrane Association and Tyrosine Phosphorylation of Dok-4, an Inhibitory Adapter Molecule Expressed in Epithelial Cells

Bedirian, A., Baldwin, C., Abe, J., Takano, T., & Lemay, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310689200 · Cited by 35

Dose- and time-dependent effects of 17beta-oestradiol on insulin sensitivity in insulin-dependent tissues of rat: implications of IRS-1

González, C., Alonso, A., Diaz, F., & PATTERSON, A. M. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1760367 · Cited by 34

Role of Rab5 in insulin receptor-mediated endocytosis and signaling

Hunker, C. M., Kruk, I., Hall, J., Giambini, H., Veisaga, M. L., & Barbieri, M. A. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.01.020 · Cited by 34

Constituents of the stem of Cucurbita moschata exhibit antidiabetic activities through multiple mechanisms

Chang, C., Hsu, C.-M., Li, T.-S., Huang, S.-D., Lin, C.-C., Yen, C., Chou, C., & Cheng, H. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.06.017 · Cited by 33

The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin

Martens, N., Wéry, M., Wang, P., Braet, F., Gertler, A., Hooghe, R. J., Vandenhaute, J., & Hooghe-Peters, E. L. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.002 · Cited by 32

G Protein-coupled Receptor-induced Sensitization of Phospholipase C Stimulation by Receptor Tyrosine Kinases

Schmidt, M., Frings, M., Mono, M., Guo, Y., Weernink, P. A. O., Evellin, S., Li, H., & Jakobs, K. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004784200 · Cited by 31

Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells

Kim, S., & Pak, Y. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.130 · Cited by 30

Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1

Xu, J., Ji, S., Venable, D. Y., Franklin, J. L., & Messina, J. L. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05977 · Cited by 31

Insulin inhibits voltage-dependent calcium influx into rod photoreceptors

Stella, S., Bryson, E. J., & Thoreson, W. B. (2001) · Neuroreport · doi:10.1097/00001756-200104170-00017 · Cited by 28

Rin1 regulates insulin receptor signal transduction pathways

Hunker, C. M., Giambini, H., Galvis, A., Hall, J., Kruk, I., Veisaga, M. L., & Barbieri, M. A. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.12.021 · Cited by 27

Diabetes: The importance of the liver

Rutter, G. A. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00737-5 · Cited by 26

Skeletal Muscle of Stroke-Prone Spontaneously Hypertensive Rats Exhibits Reduced Insulin-Stimulated Glucose Transport and Elevated Levels of Caveolin and Flotillin

James, D. J., Cairns, F., Salt, I. P., Murphy, G. J., Dominiczak, A. F., Connell, J., & Gould, G. W. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2148 · Cited by 25

Focal adhesion kinase and Src mediate integrin regulation of insulin receptor phosphorylation

Annabi, S. E., Gautier, N., & Baron, V. T. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02981-7 · Cited by 25

Lipid kinases play crucial and multiple roles in membrane trafficking and signaling.

Cm, H., Stahl, P. D., & Ma, B. (2003) · PubMed · doi:10.14670/hh-18.989 · Cited by 27

Pyruvate dehydrogenase kinase 4 (PDK4) could be involved in a regulatory role in apoptosis and a link between apoptosis and insulin resistance

Dlamini, Z., Ntlabati, P., Mbita, Z., & Shoba-Zikhali, L. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.03.022 · Cited by 23

Changes of DNA Methylation Pattern in Metabolic Pathways Induced by High-Carbohydrate Diet Contribute to Hyperglycemia and Fat Deposition in Grass Carp (Ctenopharyngodon idellus)

Cai, W.-J., Liang, X., Yuan, X., Li, A., & He, S. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00398 · Cited by 23

Exercise does not alter subcellular localization, but increases phosphorylation of insulin-signaling proteins in human skeletal muscle

Wilson, C., Hargreaves, M., & Howlett, K. F. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00314.2005 · Cited by 23

Regulation of Intermediary Metabolism During Fasting and Feeding

DeFronzo, R. A., & Ferrannini, E. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00035-4 · Cited by 22

Amino acid- and lipid-induced insulin resistance in rat heart: molecular mechanisms

Terruzzi, I., Allibardi, S., Bendinelli, P., Maroni, P., Piccoletti, R., Vesco, F., Samaja, M., & Luzi, L. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00005-9 · Cited by 21

Lipid-Induced Insulin Resistance in the Liver

Katsanos, C. S. (2004) · Sports Medicine · doi:10.2165/00007256-200434140-00002 · Cited by 21

Co-location of HDAC2 and Insulin Signaling Components in the Adult Mouse Hippocampus

Yao, Z., Liu, Y., Zhang, L., Huang, L., Ma, C., Xu, Y., Zhu, H., & Qin, C. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9859-6 · Cited by 19

Pulling Strings Below the Surface: Hormone Receptor Signaling Through Inhibition of Protein Tyrosine Phosphatases

Espanel, X., Wälchli, S., Gobert, R. P., Alama, M. E., Curchod, M., Gullu-Isler, N., & van Huijsduijnen, R. H. (2001) · Endocrine · doi:10.1385/endo:15:1:019 · Cited by 19

Glucose Homeostasis and Cardiovascular Alterations in Diabetes

Xiang, L., Mittwede, P. N., & Clemmer, J. S. (2015) · Comprehensive physiology · doi:10.1002/cphy.c150001 · Cited by 19

Increasing neutrophil F‐actin corrects CD11b exposure in Type 2 diabetes

Advani, A., Marshall, S. M., & Thomas, T. H. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01346.x · Cited by 17

Pretreatment with FK506 up-regulates insulin receptors in regenerating rat liver

Escribano, Ó., Fernández-Moreno, M. D., Pina, M. J. B., Fueyo, J., Menor, C., Román, I. D., & Guijarro, L. G. (2002) · Hepatology · doi:10.1053/jhep.2002.35439 · Cited by 17

Light Regulation of the Insulin Receptor in the Retina

Rajala, R. V. S., & Anderson, R. E. (2003) · Molecular Neurobiology · doi:10.1385/mn:28:2:123 · Cited by 15

Metabolic and Molecular Pathogenesis of Type 2 Diabetes Mellitus

DeFronzo, R. A., Mandarino, L. J., & Ferrannini, E. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0310 · Cited by 15

Insulin-Like Peptide Receptor-Mediated Signaling Pathways Orchestrate Regulation of Growth in the Pacific Oyster (Crassostrea gigas), as Revealed by Gene Expression Profiles

Li, Y., Fu, H., Zhang, F., Ren, L., Tian, J., Li, Q., & Liu, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105259 · Cited by 14

The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity

Thomas, E. C., Yang, Z., Molero, J. C., Schmitz‐Peiffer, C., Ramm, G., James, D. E., & Whitehead, J. P. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.03.009 · Cited by 13

Potentiation of Mitogenic Activity of Platelet‐Derived Growth Factor by Physiological Concentrations of Insulin via the MAP Kinase Cascade in Rat A10 Vascular Smooth Muscle Cells

Yamada, H., Tsushima, T., Murakami, H., Uchigata, Y., & Iwamoto, Y. (2001) · Journal of Diabetes Research · doi:10.1080/15604280214489 · Cited by 13

Exploiting uncertainty measures in compounds activity prediction using support vector machines

Podlewska, S., Czarnecki, W. M., Warszycki, D., & Bojarski, A. J. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.11.005 · Cited by 11

Effect of fetal dexamethasone exposure on the development of adult insulin sensitivity in a rat model

O’Brien, K., Sekimoto, H., Boney, C. M., & Malee, M. P. (2008) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050802213073 · Cited by 11

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MicroarrayAnalysis of Altered Gene Expression in Kidneys of Adult Spontaneously Hypertensive Rats

Koo, J.-R., Liang, K. H., Vaziri, N. D., & Wo, R. (2004) · Cited by 7

Regulation of Intermediatory Metabolism During Fasting and Feeding

DeFronzo, R. A., & Ferrannini, E. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00036-8 · Cited by 7

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Gies, J., & Landry, Y. (2003) · Elsevier eBooks · doi:10.1016/b978-012744481-9/50008-8 · Cited by 7

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Iliya, I., Mohammed, B., Akuyam, S., Nok, A., Bauchi, Z. M., Tanko, M., Timbuak, J., & Yusuf, B. (2016) · Sub-Saharan African Journal of Medicine · doi:10.4103/2384-5147.176267 · Cited by 6

Antidiabetic Activity

Vogel, H. G. (2007) · Springer eBooks · doi:10.1007/978-3-540-70995-4_12 · Cited by 6

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Gorbunov, E. A., Brigadirova, A. A., Качаева, Е. В., Putilovskiy, M., & Тарасов, С. А. (2015) · Problems of Endocrinology · doi:10.14341/probl201561644-54 · Cited by 4

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Isenović, E. R., Žakula, Z., Korićanac, G., & Ribarac-Stepić, N. (2006) · Acta Biologica Hungarica · doi:10.1556/abiol.57.2006.1.4 · Cited by 4

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Inoue, G., Cheatham, B., Emkey, R., & Kahn, C. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11548 · Cited by 166

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