James, David E.

Regulated transport of the glucose transporter GLUT4

Bryant, N. J., Govers, R., & James, D. E. (2002) · Nature Reviews Molecular Cell Biology

Metabolism, Diabetes, and CancerCellular transport and secretion

Cited by 1,183

Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States

Lee, Y. S., Kim, W. S., Kim, K. H., Yoon, M. J., Cho, H. J., Shen, Y., Ye, J.-M., Lee, C. H., Oh, W. K., Kim, C. T., et al. (2006) · Diabetes

Berberine and alkaloids researchMetabolism, Diabetes, and Cancer

Cited by 1,054

Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 898

Insulin resistance is a cellular antioxidant defense mechanism

Hoehn, K. L., Salmon, A. B., Hohnen-Behrens, C., Turner, N., Hoy, A. J., Maghzal, G. J., Stocker, R., Van Remmen, H., Kraegen, E. W., Cooney, G. J., et al. (2009) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 540

Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I

Turner, N., Li, J.-Y., Gosby, A., To, S. W. C., Cheng, Z., Miyoshi, H., Taketo, M. M., Cooney, G. J., Kraegen, E. W., James, D. E., et al. (2008) · Diabetes

Berberine and alkaloids researchMetabolism, Diabetes, and Cancer

Cited by 535

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Mills, R. J., Titmarsh, D. M., Koenig, X., Parker, B. L., Ryall, J. G., Quaife-Ryan, G. A., Voges, H. K., Hodson, M. P., Ferguson, C., Drowley, L., et al. (2017) · Proceedings of the National Academy of Sciences

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 478

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates

Hoffman, N. J., Parker, B. L., Chaudhuri, R., Fisher-Wellman, K. H., Kleinert, M., Humphrey, S. J., Yang, P., Holliday, M., Trefely, S., Fazakerley, D. J., et al. (2015) · Cell Metabolism

Metabolism, Diabetes, and CancerMuscle metabolism and nutrition

Cited by 426

Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway

Mills, R. J., Parker, B. L., Quaife-Ryan, G. A., Voges, H. K., Needham, E. J., Bornot, A., Ding, M., Andersson, H., Polla, M., Elliott, D. A., et al. (2019) · Cell Stem Cell

Congenital heart defects researchPluripotent Stem Cells Research

Cited by 312

Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework

Solon-Biet, S. M., Cogger, V. C., Pulpitel, T., Heblinski, M., Wahl, D., McMahon, A. C., Warren, A., Durrant-Whyte, J., Walters, K. A., Krycer, J. R., et al. (2016) · Cell Metabolism

Fibroblast Growth Factor ResearchDietary Effects on Health

Cited by 212

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance

Fazakerley, D. J., Chaudhuri, R., Yang, P., Maghzal, G. J., Thomas, K. C., Krycer, J. R., Humphrey, S. J., Parker, B. L., Fisher-Wellman, K. H., Meoli, C. C., et al. (2018) · eLife

Coenzyme Q10 studies and effectsMitochondrial Function and Pathology

Cited by 160

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

Hoehn, K. L., Turner, N., Swarbrick, M. M., Wilks, D., Preston, E., Phua, Y., Joshi, H., Furler, S. M., Larance, M., Hegarty, B. D., et al. (2010) · Cell Metabolism

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 156

Multi-Omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

Yang, P., Humphrey, S. J., Cinghu, S., Pathania, R., Oldfield, A. J., Kumar, D., Perera, D., Yang, J. Y. H., James, D. E., Mann, M., et al. (2018) · Cell Systems

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 146

Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

Yang, P., Humphrey, S. J., Cinghu, S., Pathania, R., Oldfield, A. J., Kumar, D., Perera, D., Yang, J. Y. H., James, D. E., Mann, M., et al. (2019) · Cell Systems

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 146

Vascular cells improve functionality of human cardiac organoids

Voges, H. K., Foster, S. R., Reynolds, L., Parker, B. L., Devilée, L., Quaife-Ryan, G. A., Fortuna, P. R. J., Mathieson, E., Fitzsimmons, R., Lor, M., et al. (2023) · Cell Reports

Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

Cited by 139

The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion

Pagan, J. K., Wylie, F. G., Joseph, S., Widberg, C., Bryant, N. J., James, D. E., & Stow, J. L. (2003) · Current Biology

Cellular transport and secretionImmune Response and Inflammation

Cited by 130

Signalling through the insulin receptor

Whitehead, J. P., Clark, S. F., Ursø, B., & James, D. E. (2000) · Current Opinion in Cell Biology

Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

Cited by 130

Syntaxin 7 Complexes with Mouse Vps10p Tail Interactor 1b, Syntaxin 6, Vesicle-associated Membrane Protein (VAMP)8, and VAMP7 in B16 Melanoma Cells

Wade, N., Bryant, N. J., Connolly, L. M., Simpson, R. J., Luzio, J. P., Piper, R. C., & James, D. E. (2001) · Journal of Biological Chemistry

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 89

MASTL overexpression promotes chromosome instability and metastasis in breast cancer

Rogers, S., McCloy, R. A., Parker, B. L., Gallego-Ortega, D., Law, A. M. K., Chin, V. T., Conway, J. R. W., Fey, D., Millar, E. K. A., O’Toole, S., et al. (2018) · Oncogene

Microtubule and mitosis dynamicsCancer-related Molecular Pathways

Cited by 67

Hyperinsulinemia Suppresses Glucose Utilization in Specific Brain Regions:In Vivo Studies Using the Euglycemic Clamp in the Rat

GRUNSTEIN, H. S., JAMES, D. E., STORLIEN, L. H., SMYTHE, G. A., & KRAEGEN, E. W. (1985) · Endocrinology

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 62

Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice

Kleinert, M., Parker, B. L., Fritzen, A. M., Knudsen, J. R., Jensen, T. E., Kjøbsted, R., Sylow, L., Ruegg, M., James, D. E., & Richter, E. A. (2017) · The Journal of Physiology

Metabolism, Diabetes, and CancerMuscle metabolism and nutrition

Cited by 59

Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass

Davey, J. R., Watt, K. I., Parker, B. L., Chaudhuri, R., Ryall, J. G., Cunningham, L., Qian, H., Sartorelli, V., Sandri, M., Chamberlain, J., et al. (2016) · JCI Insight

Muscle Physiology and DisordersTGF-β signaling in diseases

Cited by 51

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake

Li, J., Cantley, J., Burchfield, J. G., Meoli, C. C., Stöckli, J., Whitworth, P. T., Pant, H., Chaudhuri, R., Groffen, A. J. A., Verhage, M., et al. (2014) · Diabetologia

Pancreatic function and diabetesCellular transport and secretion

Cited by 34

Targeting of the insulin-regulatable glucose transporter (GLUT-4)

James, D. E. (1994) · Biochemical Society Transactions

Metabolism, Diabetes, and CancerCellular transport and secretion

Cited by 17