RUNX transcription factors as key targets of TGF-β superfamily signaling
Abstract
The Runt domain transcription factors, RUNX1, RUNX2 and RUNX3, are integral components of signaling cascades mediated by both TGF-beta and bone morphogenetic proteins (BMPs) in several important biological systems. RUNX2 functions synergistically with Smad1 and Smad5 to regulate bone-specific genes when BMP induces osteogenesis. RUNX3, which has been mapped to locus 1p36, is a major tumor suppressor of gastric cancer and appears to be an important component of the TGF-beta-induced tumor suppressor pathway. A possible relationship between the TGF-beta-induced tumor-suppressor pathway and a postulated tumor suppressor gene on 1p36 must be examined.
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Runx3 has roles in cancers including melanoma but has not previously been ascribed roles in normal pigment cells.
“Runx3 has roles in cancers including melanoma but has not previously been ascribed roles in normal pigment cells (63–66).”
From Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish (2025) · cites this paper as [66]
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<i>Cbfa2</i> is required for the formation of intra-aortic hematopoietic clusters
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- Authors
- Ito, Y., & Miyazono, K.
- Affiliations
- National University of Singapore (SG)
- The University of Tokyo (JP)
- Corresponding author
- Ito, Yoshiaki
- Miyazono, Kohei
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 13
- Issue
- 1
- Pages
- 43-47
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W2093820637
- Cited by
- 324
- References
- 3
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 11 · 2022: 20 · 2021: 8 · 2020: 5 · 2019: 7 · 2018: 14 · 2017: 10 · 2016: 13 · 2015: 11 · 2014: 7 · 2013: 10 · 2012: 13
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Keywords
- Runx transcription factors, RUNX1, Runx2, RUNX3, TGF-beta signaling, bone morphogenetic proteins, Smad1, Smad5, bone formation, tumor suppression, 1p36, gastric cancer, signaling pathways
- MeSH terms
- Animals, DNA-Binding Proteins, Multigene Family, Neoplasm Proteins, Proto-Oncogene Proteins, Transcription Factors, Signal Transduction, Trans-Activators, Transforming Growth Factor beta, Mice, Knockout, Transcription Factor AP-2, Core Binding Factor alpha Subunits, Core Binding Factor Alpha 1 Subunit, Core Binding Factor Alpha 2 Subunit, Core Binding Factor Alpha 3 Subunit, Mice, Smad Proteins, Smad1 Protein
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