Circulating memory CD8 + T cells are limited in forming CD103 + tissue‐resident memory T cells at mucosal sites after reinfection
Open accessAbstract
Tissue‐resident memory CD8 + T cells (T RM ) localize to barrier tissues and mediate local protection against reinvading pathogens. Circulating central memory (T CM ) and effector memory CD8 + T cells (T EM ) also contribute to tissue recall responses, but their potential to form mucosal T RM remains unclear. Here, we employed adoptive transfer and lymphocytic choriomeningitis virus reinfection models to specifically assess secondary responses of T CM and T EM at mucosal sites. Donor T CM and T EM exhibited robust systemic recall responses, but only limited accumulation in the small intestine, consistent with reduced expression of tissue‐homing and ‐retention molecules. Murine and human circulating memory T cells also exhibited limited CD103 upregulation following TGF‐β stimulation. Upon pathogen clearance, T CM and T EM readily gave rise to secondary T EM . T CM also formed secondary central memory in lymphoid tissues and T RM in internal tissues, for example, the liver. Both T CM and T EM failed to substantially contribute to resident mucosal memory in the small intestine, while activated intestinal T RM , but not liver T RM , efficiently reformed CD103 + T RM . Our findings demonstrate that circulating T CM and T EM are limited in generating mucosal T RM upon reinfection. This may pose important implications on cell therapy and vaccination strategies employing memory CD8 + T cells for protection at mucosal sites.
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As currently no Abs are available to detect murine Hobit accurately by flow cytometry, Hobit reporter mice are the tool of choice to identify and manipulate Trm.
“As currently no Abs are available to detect murine Hobit accurately by flow cytometry, Hobit reporter mice are the tool of choice to identify and manipulate Trm [251, 289] (Figure 21).”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [289]
The Flow cytometry section describes antibody staining, and Table 1 lists antibodies used, but neither addresses whether antibodies can accurately detect murine Hobit. Searches for Hobit and reporter mice found no passage in our copy supporting their use to identify or manipulate tissue-resident memory T cells. (LLM, conf=0.74)
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Li, C., Ligons, D. L., Lanasa, D., Keller, H. R., Luckey, M. A., Capaldo, B. J., Meerzaman, D. M., Park, J., & Park, J. (2025) · Immunity · doi:10.1016/j.immuni.2025.08.014 · Cited by 14 · see citing works
Tissue-Resident Memory T Cell: Ontogenetic Cellular Mechanism and Clinical Translation
Xu, H., Zhou, R., & Chen, Z. (2023) · Clinical & Experimental Immunology · doi:10.1093/cei/uxad090 · Cited by 14 · see citing works
Tissue-Resident Memory T Cells in Allergy
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Fung, H. Y., Espinal, A. M., Teryek, M., Lemenze, A., & Bergsbaken, T. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.03.002 · Cited by 9 · see citing works
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Resident memory T cell development is gradual and shows AP-1 gene expression in mature cells
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Preliminary exploration of the association of CXCR6+T lymphocytes in T2D
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- Authors
- Behr, F. M., Beumer‐Chuwonpad, A., Kragten, N. A. M., Wesselink, T. H., Stark, R., & van Gisbergen, K. P. J. M.
- Affiliations
- Sanquin (NL)
- Department of Hematopoiesis Sanquin Research and Landsteiner Laboratory Amsterdam UMC University of Amsterdam Amsterdam The Netherlands
- Corresponding author
- Behr, Felix M.
- ORCID
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2020-08-31
- Volume
- 51
- Issue
- 1
- Pages
- 151-166
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W3047752211
- Cited by
- 30
- References
- 66
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 7 · 2021: 5
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (acceptedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (016.186.116, 917.13.338)
- Landsteiner Foundation for Blood Transfusion Research
- Alexander von Humboldt-Stiftung
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- tissue-resident memory T cells, CD8+ T cells, CD103, mucosal immunity, reinfection, central memory T cells, effector memory T cells, TGF-beta, lymphocytic choriomeningitis virus, small intestine, liver, memory T cell homeostasis, adoptive T cell therapy
- MeSH terms
- Animals, Cell Differentiation, Female, Humans, Immunologic Memory, Intestinal Mucosa, Intestine, Small, Lymphocyte Activation, Lymphocytic choriomeningitis virus, Male, Mice, Inbred C57BL, Mucous Membrane, Antigens, CD, Transforming Growth Factor beta, CD8-Positive T-Lymphocytes, Immunity, Mucosal, Adoptive Transfer, Integrin alpha Chains, Mice, Adaptive Immunity
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