β-catenin: a key mediator of Wnt signaling
Abstract
Beta-catenin is a pivotal player in the signaling pathway initiated by Wnt proteins, mediators of several developmental processes. beta-catenin activity is controlled by a large number of binding partners that affect the stability and the localization of beta-catenin and is thereby able to participate in such varying processes as gene expression and cell adhesion. Activating mutations in beta-catenin and in components regulating its stability can contribute to the formation of certain tumors.
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GSK-3β phosphorylates the transcription factor Armadillo/β-catenin, which targets it for degradation.
“GSK-3β phosphorylates the transcription factor Armadillo/β-catenin, which targets it for degradation (107)”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [107]
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- Authors
- Willert, K., & Nusse, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Willert, Karl
- ORCID
- Willert, Karl
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 1998-02
- Volume
- 8
- Issue
- 1
- Pages
- 95-102
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W2006718453
- Cited by
- 753
- References
- 0
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 9 · 2023: 5 · 2022: 14 · 2021: 17 · 2020: 17 · 2019: 13 · 2018: 13 · 2017: 20 · 2016: 13 · 2015: 17 · 2014: 26 · 2013: 22 · 2012: 33
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- β-catenin, Wnt signaling, protein stability, protein localization, gene expression regulation, cell adhesion, activating mutations, tumor formation, developmental processes
- MeSH terms
- Animals, Cell Adhesion, Cytoskeletal Proteins, DNA-Binding Proteins, Humans, Proto-Oncogene Proteins, Transcription Factors, Signal Transduction, Trans-Activators, Drosophila Proteins, Wnt1 Protein, beta Catenin, Lymphoid Enhancer-Binding Factor 1
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