Kinesin-II recruits Armadillo and Dishevelled for Wingless signaling in Drosophila
Open accessAbstract
Wingless (Wg)/Wnt signaling is fundamental in metazoan development. Armadillo (Arm)/β-catenin and Dishevelled (Dsh) are key components of Wnt signal transduction. Recent studies suggest that intracellular trafficking of Wnt signaling components is important, but underlying mechanisms are not well known. Here, we show that Klp64D, the Drosophila homolog of Kif3A kinesin II subunit, is required for Wg signaling by regulating Arm during wing development. Mutations in klp64D or RNAi cause wing notching and loss of Wg target gene expression. The wing notching phenotype by Klp64D knockdown is suppressed by activated Arm but not by Dsh, suggesting that Klp64D is required for Arm function. Furthermore, klp64D and arm mutants show synergistic genetic interaction. Consistent with this genetic interaction, Klp64D directly binds to the Arm repeat domain of Arm and can recruit Dsh in the presence of Arm. Overexpression of Klp64D mutated in the motor domain causes dominant wing notching, indicating the importance of the motor activity. Klp64D shows subcellular localization to intracellular vesicles overlapping with Arm and Dsh. In klp64D mutants, Arm is abnormally accumulated in vesicular structures including Golgi, suggesting that intracellular trafficking of Arm is affected. Human KIF3A can also bind β-catenin and rescue klp64D RNAi phenotypes. Taken together, we propose that Klp64D is essential for Wg signaling by trafficking of Arm via the formation of a conserved complex with Arm.
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Primary cilia are redundant for both branches of WNT signalling.
“demonstrating that primary cilia are redundant for both branches of WNT signalling 203.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [203]
The Discussion (page unavailable) reports that studies suggest cilia have no role in Wnt signalling during early development. That narrower, hedged statement does not establish that primary cilia are redundant for both branches of WNT signalling across contexts; the same passage says their role has not been clearly defined. (LLM, conf=0.85)
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- Authors
- Vuong, L. T., Mukhopadhyay, B., & Choi, K.-W.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- MedImmune, Gaithersburg, MD 20878, USA
- Corresponding author
- Mukhopadhyay, Bibhash
- Choi, Kwang-Wook
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2014-08-15
- Volume
- 141
- Issue
- 16
- Pages
- 3222-3232
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2028822760
- Cited by
- 21
- References
- 65
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Research Foundation
- National Research Foundation of Korea (NRF-2011-0028326)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- kinesin-2, KIF3A, armadillos, β-catenin, Dishevelled, Wingless signaling, Wnt signaling, intracellular trafficking, Golgi apparatus, motor domain, Drosophila wing development, protein complex formation
- MeSH terms
- Dishevelled Proteins, Amino Acid Sequence, Animals, Drosophila melanogaster, Golgi Apparatus, Humans, Molecular Sequence Data, Mutation, Phenotype, Phosphoproteins, Transcription Factors, Wings, Animal, Signal Transduction, Kinesins, Sequence Homology, Amino Acid, Gene Expression Regulation, Developmental, Body Patterning, Gene Expression Profiling, Drosophila Proteins, RNA Interference, Adaptor Proteins, Signal Transducing, beta Catenin, Armadillo Domain Proteins
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