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Dendritic arbor development and synaptogenesis
Abstract
In vivo studies indicate that synaptic activity promotes dendritic arbor elaboration at early stages of brain development. At later stages of development, synaptic activity stabilizes dendritic structure. The different roles of synaptic activity with respect to structural plasticity probably reflect the regulated spatiotemporal expression of key components within signaling pathways.
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“Dendritic development is regulated by a combination of intrinsic programs and extrinsic factors78.”
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Metadata
- Authors
- Cline, H. T.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- Corresponding author
- Cline, Hollis T
- ORCID
- Cline, Hollis T
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 11
- Issue
- 1
- Pages
- 118-126
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2065958702
- Semantic Scholar
- 25da4cebd6ff01d6bed9db0c0f8e8329ba573e80
- Cited by
- 499
- References
- 58
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 9 · 2023: 15 · 2022: 6 · 2021: 5 · 2020: 14 · 2019: 11 · 2018: 15 · 2017: 11 · 2016: 21 · 2015: 18 · 2014: 28 · 2013: 17 · 2012: 21
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- Cold Spring Harbor Laboratory
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- dendritic arbor development, synaptogenesis, synaptic activity, structural plasticity, brain development, signaling pathways, spatiotemporal gene expression
- MeSH terms
- Animals, Brain, Brain Chemistry, Dendrites, Humans, Nervous System, Synapses, GTP Phosphohydrolases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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