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Cited by 199Head and Neck Cancer StudiesCancer survivorship and careInflammatory Biomarkers in Disease Prognosis

The DOI matches its Crossref record; 49 of the 51 references it cites were found in a registry or an index.

Sociodemographic factors and quality of life as prognostic indicators in head and neck cancer

de Graeff, A, de Leeuw, J.R.J, Ros, W.J.G, Hordijk, G.J, Blijham, G.H, Winnubst, J.A.M·2001·European Journal of Cancer
DOI 10.1016/s0959-8049(00)00385-3
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Abstract

Pre-treatment quality of life (QOL) has been found to be an independent prognostic factor for survival in cancer patients, in particular in patients with advanced cancer. Sociodemographic factors such as marital and socioeconomic status have also been recognised as prognostic factors. We studied the influence of QOL and mood (measured with the European Organization for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) and the Head and Neck Cancer Questionnaire (EORTC QLQ-H&N35), and with the Center for Epidemiologic Studies-Depression Scale (CES-D)) as measured before treatment, the use of cigarettes and alcohol and sociodemographic factors (age, gender, marital status, income and occupation) on recurrence and survival in 208 patients with head and neck cancer prior to treatment with surgery and/or radiotherapy, using Kaplan-Meier and Cox regression analyses. Cognitive functioning and, to a lesser degree, marital status were independent predictors of recurrence and survival, along with medical factors (stage and radicality). Patients with less than optimal cognitive functioning and unmarried patients had a relative risk (RR) of recurrence of 1.72 (95% confidence interval (95% CI) 1.01-2.93) and 1.85 (95% CI 1.06-3.33), respectively, and a RR of dying of 1.90 (95% CI 1.10-3.26) and 1.82 (95% CI 1.03-3.23), respectively. Performance status, physical functioning, mood and global QOL and smoking and drinking did not predict for recurrence and survival. The influence of cognitive functioning might be related to the use of alcohol. Marital status may influence prognosis through mechanisms of health behaviour and/or social support mechanisms.

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Crossref · 10.1016/s0959-8049(00)00385-3

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Metadata

Authors
de Graeff, A., de Leeuw, J. R. J., Ros, W. J. G., Hordijk, G. J., Blijham, G. H., & Winnubst, J. A. M.
Affiliations
University Medical Center Utrecht (NL)
ORCID
Ros, W.J.G
Venue
European Journal of Cancer
Publisher
Elsevier BV
Published
2001-02
Volume
37
Issue
3
Pages
332-339
ISSN
0959-8049 (ISSN-L)
DOI
10.1016/s0959-8049(00)00385-3
OpenAlex
W2080391410
Cited by
199
References
51
Citations by year
2026: 4 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 12 · 2021: 2 · 2020: 3 · 2019: 7 · 2018: 9 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 12 · 2013: 7 · 2012: 11
FWCI
8.57
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
head and neck cancer, quality of life, prognostic factors, recurrence, survival, sociodemographic factors, marital status, cognitive function, mood, depression, smoking, alcohol consumption, socioeconomic status, EORTC QLQ-H&N35, EORTC QLQ-C30, social support
MeSH terms
Alcohol Drinking, Female, Head and Neck Neoplasms, Humans, Male, Neoplasm Recurrence, Local, Prognosis, Prospective Studies, Quality of Life, Risk Factors, Smoking, Socioeconomic Factors, Multivariate Analysis, Survival Analysis

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