Osteosarcoma over the age of forty
Abstract
The European Musculo Skeletal Oncology Society (EMSOS) has carried out a retrospective review of patients over the age of 40 years with osteosarcoma. 481 patients from 12 centres or multicentric groups were included. 42 patients had osteosarcoma arising in Paget's disease, median survival was 9 months. Patients with axial or metastatic tumours also did badly whilst 41 patients with radiation-induced osteosarcoma had a prognosis paralleling conventional osteosarcoma matched for patient age and site of the tumour. 238 patients had high grade non-metastatic osteosarcoma and had a survival of 46% at 5 years. Older patients had less chemotherapy and fared worse. Osteosarcoma in the elderly is a curable condition and warrants intensive treatment with chemotherapy and surgical resection.
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There is no standard-of-care systemic therapy for patients >40 years of age with osteosarcoma, and few clinical trials inform practice.
“There is no standard-of-care systemic therapy for patients >40 years of age with a poor outcome and few clinical trials to inform practice 132 .”
From Osteosarcoma (2022) · cites this paper as [132]
Retrospective analysis of the European Musculoskeletal Oncology Society of patients over 40 years demonstrated that adult patients may benefit from aggressive treatment with surgery and chemotherapy, with outcomes possibly related to decreased chemotherapy administered to some elderly patients.
“Retrospective analysis of the European Musculoskeletal Oncology Society of patients over 40 years did demonstrate that adult patients may benefit from aggressive treatment with surgery and chemotherapy, with outcomes possibly being related to decreased chemotherapy administered to some of the elderly patients 132 .”
From Osteosarcoma (2022) · cites this paper as [132]
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- Authors
- Grimer, R. J., Cannon, S. R., Taminiau, A. M., Bielack, S., Kempf-Bielack, B., Windhager, R., Dominkus, M., Saeter, G., Bauer, H., Meller, I., Szendroi, M., Folleras, G., San-Julian, M., & van der Eijken, J.
- Affiliations
- Royal Orthopaedic Hospital (GB)
- Royal National Orthopaedic Hospital (GB)
- Leiden University Medical Center (NL)
- University Hospital Münster (DE)
- University of Graz (AT)
- University of Vienna (AT)
- Karolinska University Hospital (SE)
- Tel Aviv Sourasky Medical Center (IL)
- Corresponding author
- Grimer, R.J
- Venue
- European Journal of Cancer
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 39
- Issue
- 2
- Pages
- 157-163
- ISSN
- 0959-8049 (ISSN-L)
- OpenAlex
- W2052299135
- Cited by
- 188
- References
- 25
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 13 · 2020: 10 · 2019: 11 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 7 · 2012: 6
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
- Keywords
- osteosarcoma, elderly patients, Paget's disease, radiation-induced osteosarcoma, metastatic osteosarcoma, survival, chemotherapy, surgical resection, prognosis
- MeSH terms
- Adult, Aged, Aged, 80 and over, Bone Neoplasms, Female, Humans, Male, Middle Aged, Neoplasm Metastasis, Neoplasms, Radiation-Induced, Osteitis Deformans, Prognosis, Retrospective Studies, Osteosarcoma, Survival Analysis, Age Distribution, Sex Distribution
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