A cross-validation of the European organization for research and treatment of cancer QLQ-C30 (EORTC QLQ-C30) for Japanese with Lung Cancer
Abstract
The EORTC QLQ-C30 was developed in English-speaking cultures. To determine if this instrument could cross a broad cultural divide and be used in Japan, the cross-cultural validity of its Japanese version was estimated. In evaluating psychometric testing, internal consistency by Cronbach's alpha, item-discrimination by multitrait scaling analysis, and validity analysis with ECOG performance score (PS) and Karnofsky Performance Status Scale (KPS) were performed. The QLQ-C30 (version 1.0) was given to 105 patients with lung cancer. Although the response rate was low in patients with PS 4, the questionnaire was well accepted by patients with PS 0-3. The Japanese QLQ-C30 has a weak scale of role functioning in terms of item discriminative validity. It also has a weak scale of cognitive functioning in items of discriminative validity and internal consistency. However, known-groups comparison showed the expected clinical validity with PS for all the scales except for financial impact, and longitudinally clinical validity with KPS was shown in scales of cognitive functioning, fatigue, and nausea and vomiting. Multitrait scaling analysis showed that the predicted scales constituting quality of life (QOL) in the English-speaking culture were extracted from the Japanese QLQ-C30, and found to be valid in Japan, indicating its possible usefulness as an instrument that is universally applicable across cultures.
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The QLQ-C30 has been shown to be reliable and valid in cancer populations.
“It has been shown to be reliable and valid in cancer populations.52–54”
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- Authors
- Kobayashi, K., Takeda, F., Teramukai, S., Gotoh, I., Sakai, H., Yoneda, S., Noguchi, Y., Ogasawara, H., & Yoshida, K.
- Affiliations
- Saitama Cancer Center (JP)
- The University of Tokyo (JP)
- Corresponding author
- Kobayashi, K
- Venue
- European Journal of Cancer
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 34
- Issue
- 6
- Pages
- 810-815
- ISSN
- 0959-8049 (ISSN-L)
- OpenAlex
- W2061696005
- Cited by
- 256
- References
- 11
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 9 · 2023: 14 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 6 · 2018: 14 · 2017: 10 · 2016: 8 · 2015: 18 · 2014: 14 · 2013: 7 · 2012: 13
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Social Sciences › Education › Health Education and Validation
- Keywords
- EORTC QLQ-C30, lung cancer, cross-cultural validation, Japanese version, quality of life, cancer-related quality of life, psychometric properties, item discrimination, known-groups validity, ECOG performance status, Karnofsky performance status, role functioning, cognitive function, fatigue, nausea and vomiting, financial impact
- MeSH terms
- Cross-Cultural Comparison, Female, Humans, Japan, Lung Neoplasms, Male, Psychometrics, Surveys and Questionnaires, Sensitivity and Specificity
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