The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
A novel receptor for Apo2L/TRAIL contains a truncated death domain
Open accessAbstract
Apo2 ligand (Apo2L [1], also called TRAIL for tumor necrosis factor (TNF)-related apoptosis-inducing ligand [2]) belongs to the TNF family and activates apoptosis in tumor cells. Three closely related receptors bind Apo2L: DR4 and DR5, which contain cytoplasmic death domains and signal apoptosis, and DcR1, a decoy receptor that lacks a cytoplasmic tail and inhibits Apo2L function [3-5]. By cross-hybridization with DcR1, we have identified a fourth Apo2L receptor, which contains a cytoplasmic region with a truncated death domain. We subsequently named this protein decoy receptor 2 (DcR2). The DcR2 gene mapped to human chromosome 8p21, as did the genes encoding DR4, DR5 and DcR1. A single DcR2 mRNA transcript showed a unique expression pattern in human tissues and was particularly abundant in fetal liver and adult testis. Upon overexpression, DcR2 did not activate apoptosis or nuclear factor-kappaB; however, it substantially reduced cellular sensitivity to Apo2L-induced apoptosis. These results suggest that DcR2 functions as an inhibitory Apo2L receptor.
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Cites
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Identification and characterization of a new member of the TNF family that induces apoptosis
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Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family
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Self-citationThe Receptor for the Cytotoxic Ligand TRAIL
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Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors
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Self-citationAn Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL
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A novel domain within the 55 kd TNF receptor signals cell death
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Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95
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A death-domain-containing receptor that mediates apoptosis
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Cited by
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866
Self-citationBiochemical Pathways of Caspase Activation During Apoptosis
Budihardjo, I., Oliver, H., Lutter, M., Luo, X., & Wang, X. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.269 · Cited by 2,565
Targeting apoptosis in cancer therapy
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Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.
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Safety and antitumor activity of recombinant soluble Apo2 ligand
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Metadata
- Authors
- Marsters, S. A., Sheridan, J. P., Pitti, R. M., Huang, A., Skubatch, M., Baldwin, D., Yuan, J., Gurney, A., Goddard, A. D., Godowski, P., & Ashkenazi, A.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 7
- Issue
- 12
- Pages
- 1003-1006
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2092196409
- Cited by
- 653
- References
- 15
- FWCI
- 13.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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