The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The Receptor for the Cytotoxic Ligand TRAIL
Abstract
TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found to be an undescribed member of the TNF-receptor family (designated death receptor-4, DR4) that contains a cytoplasmic “death domain” capable of engaging the cell suicide apparatus but not the nuclear factor kappa B pathway in the system studied. Unlike Fas, TNFR-1, and DR3, DR4 could not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery. Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.
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Cites
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Cited by
Death Receptors: Signaling and Modulation
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Engineered Nanoparticles for Drug Delivery in Cancer Therapy
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Metadata
- Authors
- Pan, G., O'Rourke, K., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., & Dixit, V. M.
- Venue
- Science
- Published
- 1997-04-04
- Volume
- 276
- Issue
- 5309
- Pages
- 111-113
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092508425
- Cited by
- 1,767
- References
- 23
- FWCI
- 32.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pan, G., O'Rourke, K., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., & Dixit, V. M. (1997). The Receptor for the Cytotoxic Ligand TRAIL. Science. https://doi.org/10.1126/science.276.5309.111
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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