The DOI matches its Crossref record; 24 of the 25 references it cites were found in a registry or an index.
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
Open accessAbstract
Normal somatic cells have a finite life span [1] and lose telomeric DNA, present at the ends of chromosomes, each time they divide as a function of age in vivo or in culture [2-4]. In contrast, many cancer cells and cell lines established from tumours maintain their telomere length by activation of an RNA-protein complex called telomerase, an enzyme originally discovered in Tetrahymena [5], that synthesizes telomeric repeats [6-8]. These findings have led to the formation of the 'telomere hypothesis', which proposes that critical shortening of telomeric DNA due to the end-replication problem [9] is the signal for the initiation of cellular senescence [10,11]. In yeast, the EST2 gene product, the catalytic subunit of telomerase, is essential for telomere maintenance in vivo [12-14]. The recent cloning of the cDNA encoding the catalytic subunit of human telomerase (hTERT) [15,16] makes it possible to test the telomere hypothesis. In this study, we expressed hTERT in normal human diploid fibroblasts, which lack telomerase activity, to determine whether telomerase activity could be reconstituted leading to extension of replicative life span. Our results show that retroviral-mediated expression of hTERT resulted in functional telomerase activity in normal aging human cells. Moreover, reconstitution of telomerase activity in vivo led to an increase in the length of telomeric DNA and to extension of cellular life span. These findings provide direct evidence in support of the telomere hypothesis, indicating that telomere length is one factor that can determine the replicative life span of human cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We now know that the endpoint of this proliferative limit, termed replicative senescence, is due largely to erosion of telomeres, protective structures that cap the end of all eukaryotic chromosomes.”
From Telomere dysfunction and tumour suppression: the senescence connection (2008) · cites this paper as [4]
Experimental — accuracy not yet measuredIn the citing paper
“Telomerase activation and the resulting telomere-length maintenance leads to the bypass of senescence and ultimately to cell immortalization23,26,27.”
From Telomeres in cancer: tumour suppression and genome instability (2017) · cites this paper as [27]
In the citing paper
“Thus, telomere shortening in the absence of telomerase plays a critical role in signaling entry into senescence”
From p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis (1999) · cites this paper as Vaziri and Benchimol 1998
In the citing paper
“Ectopically expressed hTERT maintains telomere length and allows unlimited growth (Bodnar et al. 1998; Counter et al. 1998; Vaziri and Benchimol 1998”
From p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis (1999) · cites this paper as Vaziri and Benchimol 1998
In the citing paper
“Activation of telomerase results in telomere elongation, abrogation of replicative senescence, a normal karyotype and cellular immortalization.”
From Telomere dysfunction and tumour suppression: the senescence connection (2008) · cites this paper as [4]
In the citing paper
“A number of genetic validation experiments indicate that telomere maintenance by the enzyme telomerase is a key event in the immortalization process and the continuous proliferation of a large proportion of human cancers (Bodnar et al., 1998;Vaziri and Benchimol, 1998;Hahn et al., 1999a).”
From A highly selective telomerase inhibitor limiting human cancer cell proliferation (2001) · cites this paper as Vaziri and Benchimol, 1998
In the citing paper
“transfection of cells with the gene encoding the human telomerase reverse transcriptase component (hTERT) and subsequent expression of active telomerase have been shown to extend the life spans of normal human fibroblasts and epithelial cells (25–27).”
From Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death (1999) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 2×
“[6–8].”
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200
Self-citationMorgenstern, J. P., & Land, H. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.12.3587 · Cited by 2,099
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096 · cited 1×
“[6–8].”
Research works printed but not linked: 1
- Olovnikov, 1971, A theory of marginotomy, Doklay Biochem, 201, 394
Cited by
Sorted by citations
Items 701–800 of 991
Puthumana, J., Sukumaran, V., Priyaja, P., Philip, R., & Singh, I. S. B. (2015) · Cytotechnology · doi:10.1007/s10616-015-9890-9 · Cited by 10
Strict control of telomerase activation using Cre-mediated inversion
Ungrin, M., & Harrington, L. A. (2006) · BMC Biotechnology · doi:10.1186/1472-6750-6-10 · Cited by 10
Telomerase: from Aging to Human Cancers
Parsa, N. (2012) · Springer eBooks · doi:10.1007/978-94-007-4632-9_1 · Cited by 15
Immortalization of bovine mammary epithelial cells alone by human telomerase reverse transcriptase
Zhao, C., Hu, H., Meng, L., Li, Q., & Lin, A. (2010) · Cell Biology International · doi:10.1042/cbi20100006 · Cited by 10
The Cytotoxic Effects of Single-Stranded Telomere Mimics on OMA-BL1 Cells
Page, T. J., Mata, J. E., Bridge, J. A., Siebler, J., Neff, J. R., & Iversen, P. L. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4613 · Cited by 10
T cell function in the aged: Lessons learned from animal models
Linton, P., Lustgarten, J., & Thoman, M. L. (2006) · Clinical and Applied Immunology Reviews · doi:10.1016/j.cair.2006.06.001 · Cited by 10
Senescence and Senescence-Related Disorders
Wang, Z. P., & Inuzuka, H. (2013) · InTech eBooks · doi:10.5772/56158 · Cited by 12
Bisphosphonates decrease telomerase activity and hTERT expression in MCF-7 breast cancer cells
Carbonare, L. D., Valenti, M. T., Azzarello, G., Balducci, E., Crepaldi, G., Realdi, G., Vinante, O., & Giannini, S. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.03.018 · Cited by 10
Telomerase: is it the future diagnostic and prognostic tool in human cancer?
Mabruk, M. J. E. M. F., & O’Flatharta, C. (2005) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.5.6.907 · Cited by 10
Lubin, B. H., Eraklis, M., & Apicelli, G. (1999) · Advances in Pediatrics · doi:10.1016/s0065-3101(24)00036-7 · Cited by 10
Telomere-related components are coordinately synthesized during human T-lymphocyte activation
Kosciolek, B. A., & Rowley, P. T. (1999) · Leukemia Research · doi:10.1016/s0145-2126(99)00134-4 · Cited by 10
Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4
Forsyth, N. R., Morrison, V., Craig, N. J., Fitzsimmons, S. A., Barr, N. I., Ireland, H., Gordon, K., Dowen, S. E., Cuthbert, A. P., Newbold, R. F., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205688 · Cited by 10
[Telomerase and telomere: their structure and dynamics in health and disease].
Gómez, D. L. M., Armando, R. G., Fariña, H. G., & Gomez, D. E. (2014) · PubMed · Cited by 9
Generation of Human Cell Lines Using Lentiviral-Mediated Genetic Engineering
Salmon, P. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-125-7_25 · Cited by 9
Differential decrease in soluble and DNA-bound telomerase in senescent human fibroblasts
Yehuda, S., Yanai, H., Priel, E., & Fraifeld, V. E. (2017) · Biogerontology · doi:10.1007/s10522-017-9688-6 · Cited by 9
Evolution of Secondary Hematologic Disorders: PREMDS→MDS→sAML
Preisler, H. D. (2001) · Cancer treatment and research · doi:10.1007/978-1-4615-1463-3_11 · Cited by 9
Ponizovskiy, M. R. (2013) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.2013005686 · Cited by 9
Telomeres and Telomerase: The Commitment Theory of Cellular Ageing Revisited
Holliday, R. (2012) · Science Progress · doi:10.3184/003685012x13361526995348 · Cited by 9
Telomerase is Frequently Activated in Tumors with Microsatellite Instability
de Cáceres, I. I., Frolova, N., Varkonyi, R. J., Dulaimi, E., Meropol, N. J., Broccoli, D., & Cairns, P. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.3.695 · Cited by 9
Shi, Y., Cui, Y., Wu, H., Zhang, W., Zhao, C., Liu, H., Lan-qin, G., Wu, B., Ai-zhen, Y. U., & ZHANG, Y.-Y. (2012) · 中医杂志：英文版 · doi:10.1016/s0254-6272(12)60030-2 · Cited by 9
Headspace measurements of irradiated in vitro cultured cells using PTR-MS
Brunner, C. C., Szymczak, W., Li, W. B., Hoeschen, C., Mörtl, S., Eckardt‐Schupp, F., & Oeh, U. (2010) · Radiation and Environmental Biophysics · doi:10.1007/s00411-010-0327-8 · Cited by 9
Mitani, A., Kobayashi, T., Hayashi, Y., Matsushita, N., Matsushita, S., Nakao, S., Takahira, N., Shiraishi, A., & Ohashi, Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222454 · Cited by 9
Ren, S., Yang, X. Y., Peng, T., Qiu, X., Wang, X., Yin, X., Wan, X., Sun, Y., & Chen, H.-T. (2022) · Journal of Virological Methods · doi:10.1016/j.jviromet.2022.114605 · Cited by 9
Xie, X., Pang, M., Shan, L., Yu, L., Zhao, Y., Ma, K., Kalhoro, D. H., Lu, C., & Liu, Y. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6794-8 · Cited by 9
Prevalence of Telomerase in Coronary Artery Atherosclerosis
GUPTA, M., Shogreen, M. R., Braden, G. A., White, W. L., & Sane, D. C. (2000) · Rejuvenation Research · doi:10.1089/rej.1.2000.3.15 · Cited by 9
Analysis of Tumor Suppressor Gene-Induced Senescence
Campisi, J. (2003) · Humana Press eBooks · doi:10.1385/1-59259-329-1:155 · Cited by 9
Tan, Z. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00185-6 · Cited by 9
Molecular mechanisms regulating telomerase activity
Liu, J. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)08003-8 · Cited by 9
UP1 Extends Life of Primary Porcine Fetal Fibroblasts in Culture
Mir, B., Tanner, N. J., Chowdhary, B. P., & Piedrahita, J. A. (2003) · Cloning and Stem Cells · doi:10.1089/153623003322234740 · Cited by 9
An Anchorage Nuclear Structure for Telomeric DNA Repeats in HeLa Cells
Pierron, G., & Puvion-Dutilleul, F. (1999) · Chromosome Research · doi:10.1023/a:1009253917125 · Cited by 8
Effects of lead and selenium on yeast(Saccharomyces cerevisiae)telomere
Cui, Q., & Tang, C. (2000) · Journal of Environmental Science and Health Part A · doi:10.1080/10934520009377062 · Cited by 8
Phenoptosis, another specialized neologism, or the mark of a widespread revolution?
Libertini, G. (2012) · Biochemistry (Moscow) · doi:10.1134/s0006297912070139 · Cited by 8
Mangerini, R., Lanino, E., Terranova, P., Faraci, M., Pistillo, M. P., Gaetani, G. F., & Ferraris, A. M. (2009) · Annals of Hematology · doi:10.1007/s00277-009-0712-z · Cited by 8
Role of Cell Senescence in Human Aging
Fossel, M. (2000) · Rejuvenation Research · doi:10.1089/rej.1.2000.3.91 · Cited by 8
Arish, N., Cohen, P. Y., Golan‐Gerstl, R., Fridlender, Z. G., Richter-Dayan, M., Zisman, P., Breuer, R., & Wallach‐Dayan, S. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126730 · Cited by 9
Telomerase as a Target for Cancer Therapeutics
Shay, J. W. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6102-0_13 · Cited by 8
Guiducci, C., Anglana, M., Wang, A., & Bacchetti, S. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5189 · Cited by 8
The INK4A/Arf Network — Cell Cycle Checkpoint or Emergency Brake?
del Arroyo, A. G., & Peters, G. G. (2005) · Advances in experimental medicine and biology · doi:10.1007/1-4020-3764-3_8 · Cited by 8
Three molecular determinants of malignant conversion and their potential as therapeutic targets
Dome, J. S., & Look, A. T. (1999) · Current Opinion in Oncology · doi:10.1097/00001622-199901000-00013 · Cited by 8
Nagpal, N., & Agarwal, S. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01429-1 · Cited by 8
Hartwig, F. P. (2014) · Aging and Disease · doi:10.14336/ad.2014.050017 · Cited by 7
Erichsen, L., Kloss, L. D. F., Thimm, C., Bohndorf, M., Schichel, K., Wruck, W., & Adjaye, J. (2023) · Cells · doi:10.3390/cells12030342 · Cited by 7
Large defects of type I allergic response in telomerase reverse transcriptase knockout mice
Ujike, A., Okada, A., Du, Y., Maruyama, M., Yuan, X., Ishikawa, F., Motoo, Y., Isobe, K., & Nakajima, H. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1006638 · Cited by 7
hTR RNA component as a marker of cellular proliferation in oral lichen planus.
Flatharta, C. Ó., Flint, S. R., Toner, M. E., & Mabruk, M. J. E. M. F. (2008) · PubMed · Cited by 7
Rhadinovirus vector-derived human telomerase reverse transcriptase expression in primary T cells
Toptan, T., Ensser, A., & Fickenscher, H. (2010) · Gene Therapy · doi:10.1038/gt.2010.3 · Cited by 7
Establishment of Immortal Swine Kidney Epithelial Cells
Kwak, S., Jung, J.-E., Jin, X., Kim, S.-M., Kim, T.-K., Lee, J.-S., Lee, S.-Y., Pian, X., You, S., Kim, H., et al. (2006) · Animal Biotechnology · doi:10.1080/10495390500461070 · Cited by 7
Translating basic aging research into geriatric health care
Hamerman, D., & Zeleznik, J. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00200-x · Cited by 7
Wilmut, I., Clark, A., & Harley, C. B. (2000) · Nature Biotechnology · doi:10.1038/76430 · Cited by 7
Gatza, C. E., Hinkal, G. W., Moore, L. M., Dumble, M. L., & Donehower, L. A. (2005) · Elsevier eBooks · doi:10.1016/b978-012088387-5/50009-1 · Cited by 7
The Concept of Phenoptosis and its Usefulness for Controlling Aging
Libertini, G. (2014) · Current Aging Science · doi:10.2174/1874609807666140521103706 · Cited by 6
Insights into the structure and function of Est3 from the Hansenula polymorpha telomerase
Shepelev, N. M., Mariasina, S. S., Mantsyzov, A. B., Malyavko, A. N., Vladimirovich, E. S., Petrova, O. A., Rodina, E. V., Zvereva, M. I., Донцова, О. А., & Polshakov, V. I. (2020) · Scientific Reports · doi:10.1038/s41598-020-68107-x · Cited by 6
Comparison of telomerase activity between malignant and tuberculous pleural effusions.
Maneechotesuwan, K., Lertworawiwat, A., Tscheikuna, J., & Wamanuttajinda, V. (2006) · PubMed · Cited by 6
Carmean, N., Kosman, J., Leaf, E. M., Hudson, A. E., Opheim, K. E., & Bassuk, J. A. (2007) · Cell Proliferation · doi:10.1111/j.1365-2184.2007.00428.x · Cited by 6
Zaunbrecher, G. M., Mir, B., Dunne, P. W., Breen, M., & Piedrahita, J. A. (2008) · Animal Biotechnology · doi:10.1080/10495390701670099 · Cited by 6
Mattson, M. P., Zhang, P., & Cheng, A. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-133-8_15 · Cited by 6
Le clonage, une fausse immortalité
de Montera, B. (2003) · Etudes sur la mort/Études sur la mort · doi:10.3917/eslm.124.0065 · Cited by 6
Valenti, M. T., Carbonare, L. D., Bertoldo, F., Donatelli, L., & Cascio, V. L. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.10.067 · Cited by 6
TELOMERASE‐DEPENDENT REACTIVATION OF DNA SYNTHESIS IN MACROPHAGES IMPLIES ALTERATION OF TELOMERES
Yegorov, Y. E., Kazimirchuk, E. V., Terekhov, S. M., Karachentsev, D., Shirokova, E. A., Khandazhinskaya, A. L., Meshcheryakova, J. A., Corey, D. R., & Zelenin, A. V. (2002) · Cell Biology International · doi:10.1006/cbir.2002.0961 · Cited by 6
Bone Marrow Stromal Stem Cells for Repairing the Skeleton
Shi, S., & Wang, C. (2004) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2004.10648052 · Cited by 6
Back to Immortality: The Restoration of Embryonic Telomere Length During Induced Pluripotency
West, M. D., & Vaziri, H. (2010) · Regenerative Medicine · doi:10.2217/rme.10.51 · Cited by 6
Self-citationTelomeres and Cell Division Potential
Perrem, K., & Reddel, R. R. (1999) · Progress in molecular and subcellular biology · doi:10.1007/978-3-662-06227-2_8 · Cited by 6
Pandita, T. K. (2002) · Elsevier eBooks · doi:10.1016/b0-12-227555-1/00237-9 · Cited by 6
Cox, L. S. (2022) · The Journal of the Economics of Ageing · doi:10.1016/j.jeoa.2022.100423 · Cited by 6
Chen, Z., Meng, D., Pang, X., Guo, J., Li, T., Song, J. W., & Peng, Y. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1440855 · Cited by 5
Human granulosa cells of poor ovarian responder patients display telomeres shortening
Yung, Y., Maydan, S. A., Bart, Y., Orvieto, R., & Aizer, A. (2023) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-023-02860-6 · Cited by 5
Saad, F. A. (2024) · Current Gene Therapy · doi:10.2174/0115665232286489240320051925 · Cited by 5
Targeting Telomerase in Hematologic Malignancy
Maritz, M. F., Napier, C. E., Wen, V. W., & MacKenzie, K. L. (2010) · Future Oncology · doi:10.2217/fon.10.42 · Cited by 5
Sainova, I. V. (2011) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp11.222 · Cited by 5
Molecular Genetics and Cancer Biology
Gonzalgo, M. L., & Meeker, A. K. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6911-9.00018-9 · Cited by 5
The role of telomerase in age-related degenerative disease and cancer
Fossel, M. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)07019-5 · Cited by 5
Golub, N. I., & Chernyk, I. I. (2008) · Cytology and Genetics · doi:10.1007/s11956-008-1005-5 · Cited by 5
Telomeres and Telomerase Regulation
Lansdorp, P. M. (2004) · Elsevier eBooks · doi:10.1016/b978-012436643-5/50101-2 · Cited by 6
Augert, A., & Bernar, D. (2013) · InTech eBooks · doi:10.5772/55519 · Cited by 6
Exploring cellular senescence as a tumor suppressor mechanism
Carnero, A., Blanco‐Aparicio, C., Blanco, F., Castro, M. E., Guijarro, M. V., Fominaya, J. M., Link, W., Martínez, J. F., Moneo, V., Renner, O., et al. (2003) · Revista de Oncología · doi:10.1007/bf02711481 · Cited by 6
Wu, X., Song, B., Zhang, J., Li, L., Ji, H., Lu, G., Chen, Z., Li, W., & Zhou, Z. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02603.x · Cited by 5
Inhibition of PP2A Activity Confers a TRAIL-Sensitive Phenotype during Malignant Transformation
Yang, H., Chen, X., Wang, X., Li, Y., Chen, S., Qian, X., Wang, R., Chen, L., Han, W., Ruan, A., et al. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0441 · Cited by 7
Telomere Length Changes in Human Cancer
Broccoli, D., & Godwin, A. K. (2003) · Humana Press eBooks · doi:10.1385/1-59259-135-3:271 · Cited by 5
Reply to 'Telomerase and cellular lifespan: Ending the debate?'
Rubin, H. (1998) · Nature Biotechnology · doi:10.1038/nbt0898-702a · Cited by 5
Generation of surrogate beta cells from tissue stem cells
Efrat, S. (2004) · Current Diabetes Reports · doi:10.1007/s11892-004-0082-9 · Cited by 5
Sengstack, J., Zheng, J., Mobaraki, M., Lin, J., Deng, C., & Li, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.20.517270 · Cited by 6
Zhang, H., Wang, F., Chen, H.-T., Wang, S., Tong, L., Wang, H., Fan, J., Yin, X., Wang, X., Sun, Y., et al. (2024) · Virology · doi:10.1016/j.virol.2024.110352 · Cited by 4
Wang, Y., Zhou, L. F., Liu, J., Zhou, Q., Xiong, W., & Wang, L. (2025) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaf073 · Cited by 4
From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines
Deng, F., Peña, V., Morales‐Sosa, P., Rivera, A. B., Yang, B., Huang, S., Ghosh, S., Katt, M. L., Castellano, L. A., Maddera, L. E., et al. (2025) · Cells · doi:10.3390/cells14151190 · Cited by 4
Decoding senescent drivers in Alzheimer's disease: From bench to bedside
Zhou, R., Lin, X., Liao, Z., Lin, J., Zheng, R., Ni, H., Liu, W., Feng, Z., He, Q., Lin, X., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102978 · Cited by 4
Evaluation of telomerase expression in chronic periodontitis
Rao, S., Balaji, T., Venkatesan, V., & Paul, S. F. D. (2010) · Indian Journal of Dental Research · doi:10.4103/0970-9290.66632 · Cited by 4
Immortalisation of Primary Cells
Stacey, G. N., & MacDonald, C. M. L. A. (2001) · Springer eBooks · doi:10.1007/978-94-017-0996-5_3 · Cited by 4
PinX1 plays multifaceted roles in human cancers: a review and perspectives
You, D., Tong, K., Li, Y., Zhang, T., Wu, Y., Wang, L., Chen, G., & Zhang, X. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-10082-x · Cited by 4
Hunt, A., Betts, D. H., King, W. A., & Madan, P. (2010) · SURG Journal · doi:10.21083/surg.v3i2.1118 · Cited by 4
Wells, T. B., Zhang, G., Harley, Z., & Vaziri, H. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-07-0748 · Cited by 4
Self-citationLi, J., Said, A., Xiu-guo, G., Wang, W., Zhang, Y., & Jin, T. (2017) · Cytotechnology · doi:10.1007/s10616-017-0114-3 · Cited by 4
Critical telomerase activity for uncontrolled cell growth
Wesch, N. L., Burlock, L. J., & Gooding, R. J. (2016) · Physical Biology · doi:10.1088/1478-3975/13/4/046005 · Cited by 4
Robinson, M. O. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4199-8_12 · Cited by 4
Protection from acute cellular injury using Sleeping Beauty mediated telomerase gene transfer
Song, J. S., Murase, N., Demetris, A. J., Michalopoulos, G. K., & Ochoa, E. R. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.213 · Cited by 4
Genetic Basis of the Barrett???s Metaplasia, Dysplasia, Adenocarcinoma Sequence
Lord, R. V. (2001) · Problems in General Surgery · doi:10.1097/00013452-200106000-00008 · Cited by 4
Hopkin, K. (2001) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2001.1.oa4 · Cited by 4
Hao, Y., & Tan, Z. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00129-2 · Cited by 4
Boltina, I. (2007) · Cytology and Genetics · doi:10.3103/s0095452707010082 · Cited by 3
Safety Study of AAV hTert and Klotho Gene Transfer Therapy for Dementia
Sewell, P. E. (2021) · Journal of Regenerative Biology and Medicine · doi:10.37191/mapsci-2582-385x-3(6)-097 · Cited by 3
Modeling telomere shortening process
Han, P., Zhou, Y., & Deng, W. (2024) · Quantitative Biology · doi:10.1002/qub2.74 · Cited by 3
Settineri, R. A., Ji, J., Luo, C., Ellithorpe, R. R., Ferreira, G., Rosenblatt, S., LaValle, J. B., Jinenez, A., Ohta, S., & Nicolson, G. L. (2019) · American Journal of Food and Nutrition · doi:10.12691/ajfn-4-6-4 · Cited by 3
Metadata
- Authors
- Vaziri, H., & Benchimol, S.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Benchimol, Samuel
- ORCID
- Benchimol, Samuel
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 1998-02
- Volume
- 8
- Issue
- 5
- Pages
- 279-282
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2100550233
- Cited by
- 1,003
- References
- 25
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 12 · 2023: 8 · 2022: 13 · 2021: 11 · 2020: 12 · 2019: 15 · 2018: 9 · 2017: 15 · 2016: 20 · 2015: 27 · 2014: 17 · 2013: 28 · 2012: 31
- FWCI
- 48.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- telomerase, hTERT, telomere length, replicative lifespan, cellular senescence, telomere maintenance, retroviral gene transfer, human diploid fibroblasts, telomeric DNA, end-replication problem
- MeSH terms
- Animals, Catalysis, Cells, Cultured, DNA Replication, DNA-Binding Proteins, Fibroblasts, Humans, Protein Conformation, Proteins, Retroviridae, RNA, Tetrahymena, Telomere, Cellular Senescence, Telomerase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
