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Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
Open accessAbstract
Normal somatic cells have a finite life span [1] and lose telomeric DNA, present at the ends of chromosomes, each time they divide as a function of age in vivo or in culture [2-4]. In contrast, many cancer cells and cell lines established from tumours maintain their telomere length by activation of an RNA-protein complex called telomerase, an enzyme originally discovered in Tetrahymena [5], that synthesizes telomeric repeats [6-8]. These findings have led to the formation of the 'telomere hypothesis', which proposes that critical shortening of telomeric DNA due to the end-replication problem [9] is the signal for the initiation of cellular senescence [10,11]. In yeast, the EST2 gene product, the catalytic subunit of telomerase, is essential for telomere maintenance in vivo [12-14]. The recent cloning of the cDNA encoding the catalytic subunit of human telomerase (hTERT) [15,16] makes it possible to test the telomere hypothesis. In this study, we expressed hTERT in normal human diploid fibroblasts, which lack telomerase activity, to determine whether telomerase activity could be reconstituted leading to extension of replicative life span. Our results show that retroviral-mediated expression of hTERT resulted in functional telomerase activity in normal aging human cells. Moreover, reconstitution of telomerase activity in vivo led to an increase in the length of telomeric DNA and to extension of cellular life span. These findings provide direct evidence in support of the telomere hypothesis, indicating that telomere length is one factor that can determine the replicative life span of human cells.
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In the citing paper
“We now know that the endpoint of this proliferative limit, termed replicative senescence, is due largely to erosion of telomeres, protective structures that cap the end of all eukaryotic chromosomes.”
From Telomere dysfunction and tumour suppression: the senescence connection (2008) · cites this paper as [4]
Experimental — accuracy not yet measuredIn the citing paper
“Telomerase activation and the resulting telomere-length maintenance leads to the bypass of senescence and ultimately to cell immortalization23,26,27.”
From Telomeres in cancer: tumour suppression and genome instability (2017) · cites this paper as [27]
In the citing paper
“Thus, telomere shortening in the absence of telomerase plays a critical role in signaling entry into senescence”
From p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis (1999) · cites this paper as Vaziri and Benchimol 1998
In the citing paper
“Ectopically expressed hTERT maintains telomere length and allows unlimited growth (Bodnar et al. 1998; Counter et al. 1998; Vaziri and Benchimol 1998”
From p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis (1999) · cites this paper as Vaziri and Benchimol 1998
In the citing paper
“Activation of telomerase results in telomere elongation, abrogation of replicative senescence, a normal karyotype and cellular immortalization.”
From Telomere dysfunction and tumour suppression: the senescence connection (2008) · cites this paper as [4]
In the citing paper
“A number of genetic validation experiments indicate that telomere maintenance by the enzyme telomerase is a key event in the immortalization process and the continuous proliferation of a large proportion of human cancers (Bodnar et al., 1998;Vaziri and Benchimol, 1998;Hahn et al., 1999a).”
From A highly selective telomerase inhibitor limiting human cancer cell proliferation (2001) · cites this paper as Vaziri and Benchimol, 1998
In the citing paper
“transfection of cells with the gene encoding the human telomerase reverse transcriptase component (hTERT) and subsequent expression of active telomerase have been shown to extend the life spans of normal human fibroblasts and epithelial cells (25–27).”
From Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death (1999) · cites this paper as [26]
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Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 2×
“[6–8].”
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200
Self-citationMorgenstern, J. P., & Land, H. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.12.3587 · Cited by 2,099
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096 · cited 1×
“[6–8].”
Research works printed but not linked: 1
- Olovnikov, 1971, A theory of marginotomy, Doklay Biochem, 201, 394
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Betts, D. H., & Madan, P. (2008) · Molecular Human Reproduction · doi:10.1093/molehr/gan035 · Cited by 131
Holyoake, T. L., Jiang, X., Drummond, M. W., Eaves, A., & Eaves, C. J. (2002) · Leukemia · doi:10.1038/sj.leu.2402444 · Cited by 129
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Zhang, H. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20919 · Cited by 136
Thomas, M., Yang, L., & Hornsby, P. J. (2000) · Nature Biotechnology · doi:10.1038/71894 · Cited by 128
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Artandi, S. E., & DePinho, R. A. (2000) · Nature Medicine · doi:10.1038/78595 · Cited by 126
Immortalisation and transformation revisited
Drayton, S. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00271-4 · Cited by 129
Role of telomeres and telomerase in genomic instability, senescence and cancer
Deng, Y., & Chang, S. S. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700673 · Cited by 127
Mechanisms of chromosome instability in cancers
Jefford, C. E., & Irminger‐Finger, I. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2006.02.005 · Cited by 129
Evolving views of telomerase and cancer
Blasco, M. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00085-0 · Cited by 123
Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells
Ramunas, J., Yakubov, E., Brady Jennifer, J., Corbel, S. Y., Holbrook, C., Brandt, M., Stein, J., Santiago, J. G., Cooke, J. P., & Blau, H. M. (2015) · The FASEB Journal · doi:10.1096/fj.14-259531 · Cited by 129
Hormones and growth factors regulate telomerase activity in ageing and cancer
Bayne, S., & Liu, J. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.05.009 · Cited by 127
Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformationPreprint
Woo, R. A., & Poon, R. Y. C. (2004) · Genes & Development · doi:10.1101/gad.1165204 · Cited by 129
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Graham, M. K., & Meeker, A. K. (2017) · Nature Reviews Urology · doi:10.1038/nrurol.2017.104 · Cited by 125
Cancer genetics: from Boveri and Mendel to microarrays
Balmain, A. (2001) · Nature reviews. Cancer · doi:10.1038/35094086 · Cited by 122
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Xu, S. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500263 · Cited by 125
New prospects for targeting telomerase beyond the telomere
Arndt, G. M., & MacKenzie, K. L. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.55 · Cited by 120
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Schnabl, B., Choi, Y. H., Olsen, J. C., Hagedorn, C. H., & Brenner, D. A. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780426 · Cited by 123
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Sabin, R. J., & Anderson, R. M. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-7 · Cited by 123
Grabowski, P., Hultdin, M., Karlsson, K., Tobin, G., Åleskog, A., Thunberg, U., Laurell, A., Sundström, C., Rosenquist, R., & Roos, G. (2005) · Blood · doi:10.1182/blood-2004-11-4394 · Cited by 123
SV40 infection induces telomerase activity in human mesothelial cells
Foddis, R., Rienzo, A. D., Broccoli, D., Bocchetta, M., Stekala, E., Rizzo, P., Tosolini, A., Grobelny, J. V., Jhanwar, S. C., Pass, H. I., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205203 · Cited by 117
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Yang, J., Liu, M., Hong, D., Zeng, M., & Zhang, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.722205 · Cited by 125
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Hayashi, T., Yano, K., Matsui‐Hirai, H., Yokoo, H., Hattori, Y., & Iguchi, A. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.09.002 · Cited by 116
Wang, Z., Kyo, S., Takakura, M., Tanaka, M., Yatabe, N., Maida, Y., Fujiwara, M., Hayakawa, J., Ohmichi, M., Koike, K., et al. (2000) · PubMed · Cited by 116
A three-dimensional model of differentiation of immortalized human bronchial epithelial cells
Vaughan, M. B., Ramirez, R. D., Wright, W. E., Minna, J. D., & Shay, J. W. (2006) · Differentiation · doi:10.1111/j.1432-0436.2006.00069.x · Cited by 114
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Liu, S., Hatton, M. P., Khandelwal, P., & Sullivan, D. A. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-5108 · Cited by 114
Use of exogenous hTERT to immortalize primary human cells
Lee, K. M., Choi, K. H., & Ouellette, M. M. (2004) · Cytotechnology · doi:10.1007/10.1007/s10616-004-5123-3 · Cited by 121
p16INK4a and the control of cellular proliferative life span
Huschtscha, L. I. (1999) · Carcinogenesis · doi:10.1093/carcin/20.6.921 · Cited by 110
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Lee, K.-H., Rudolph, K. L., Ju, Y.-J., Greenberg, R. A., Cannizzaro, L. A., Chin, L., Weiler, S. R., & DePinho, R. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051629198 · Cited by 111
Wieler, S., Gagné, J., Vaziri, H., Poirier, G. G., & Benchimol, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211641200 · Cited by 110
Self-citationVenetsanakos, E., Mirza, A. M., Fanton, C. P., Romanov, S. R., Tlsty, T. D., & McMahon, M. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5424 · Cited by 109
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Urquidi, V., Tarin, D., & Goodison, S. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.65 · Cited by 110
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Gorospe, M., & Abdelmohsen, K. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.03.005 · Cited by 108
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Dagarag, M. D., Evazyan, T., Rao, N. P., & Effros, R. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.10.6303 · Cited by 107
Narala, S. R., Allsopp, R. C., Wells, T. B., Zhang, G., Prasad, P., Coussens, M. J., Rossi, D. J., Weissman, I. L., & Vaziri, H. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0965 · Cited by 106
Self-citationTelomerase Activity Does Not Always Imply Telomere Maintenance
Ouellette, M. M., Aisner, D. L., Savre‐Train, I., Wright, W. E., & Shay, J. W. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.0114 · Cited by 106
Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress
Rubio, M. Á., Davalos, A. R., & Campisi, J. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.04.004 · Cited by 105
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Zhu, C.-Q., Jc, C., Liu, N., D, L., Shepherd, F. A., Squire, J. A., & Tsao, M. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603110 · Cited by 108
Luiten, R. M., Pène, J., Yssel, H., & Spits, H. (2003) · Blood · doi:10.1182/blood-2002-07-2018 · Cited by 104
Momin, E. N., Vela, G., Zaidi, H. A., & Quiñones‐Hinojosa, A. (2010) · Current Immunology Reviews · doi:10.2174/157339510791111718 · Cited by 106
Vaziri, H., Squire, J. A., Pandita, T. K., Bradley, G., Kuba, R. M., Zhang, H., Gulyás, S., Hill, R. P., Nolan, G. P., & Benchimol, S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2373 · Cited by 104
Self-citationSmurf2 up-regulation activates telomere-dependent senescence
Zhang, H., & Cohen, S. N. (2004) · Genes & Development · doi:10.1101/gad.1253004 · Cited by 100
Liu, L., Blasco, M. A., & Keefe, D. L. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf055 · Cited by 102
Horner, S. M., DeFilippis, R. A., Manuelidis, L., & DiMaio, D. (2004) · Journal of Virology · doi:10.1128/jvi.78.8.4063-4073.2004 · Cited by 102
Guo, Q., Lin, S., You, Q., Gu, H.-Y., Yu, J., Zhao, L., Qi, Q., Liang, F., Tan, Z., & Wang, X. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.06.046 · Cited by 102
Kaul, S. C., Yaguchi, T., Taira, K., Reddel, R. R., & Wadhwa, R. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00101-0 · Cited by 101
Yudoh, K., Matsuno, H., Nakazawa, F., Katayama, R., & Kimura, T. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.8.1453 · Cited by 103
Kang, H.-J., Cui, Y., Yin, H., Scheid, A., Hendricks, W. P. D., Schmidt, J. E., Sekulić, A., Kong, D., Trent, J. M., Gokhale, V. M., et al. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b07598 · Cited by 100
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Turel, I., & Kljun, J. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611798040787 · Cited by 101
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Kogan, I., Goldfinger, N., Milyavsky, M., Cohen, M., Shats, I., Dobler, G., Klocker, H., Wasylyk, B., Völler, M., Aalders, T. W., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2183 · Cited by 98
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Jemielity, S., Kimura, M., Parker, K. M., Parker, J. D., Cao, X., Aviv, A., & Keller, L. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00279.x · Cited by 97
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Endoh, T., Tsuji, N., Asanuma, K., Yagihashi, A., & Watanabe, N. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.12.014 · Cited by 94
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Telomerase: regulation, function and transformation
Dong, C. K., Masutomi, K., & Hahn, W. C. (2005) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2004.12.005 · Cited by 96
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MacKenzie, K. L., Franco, S., May, C., Sadelain, M., & Moore, M. A. S. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4982 · Cited by 92
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Wood, L. D., Halvorsen, T. L., Dhar, S., Baur, J. A., Pandita, R. K., Wright, W. E., Hande, M. P., Calaf, G., Hei, T. K., Levine, F., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204072 · Cited by 91
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Venkatesan, R. N., & Price, C. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14763 · Cited by 93
Influence of age on wound healing and fibrosis
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Grobelny, J. V. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.18.1953 · Cited by 90
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Madar, S., Brosh, R., Buganim, Y., Ezra, O., Goldstein, I., Solomon, H., Kogan, I., Goldfinger, N., Klocker, H., & Rotter, V. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn232 · Cited by 90
Poppler, L. H., Ee, X., Schellhardt, L., Hoben, G. M., Pan, D., Hunter, D. A., Yan, Y., Moore, A. M., Snyder‐Warwick, A. K., Stewart, S. A., et al. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0003 · Cited by 87
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Cudré-Mauroux, C., Occhiodoro, T., König, S., Salmon, P., Bernheim, L., & Trono, D. (2003) · Human Gene Therapy · doi:10.1089/104303403322495034 · Cited by 86
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Oguchi, K., Liu, H., Tamura, K., & Takahashi, H. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01083-2 · Cited by 85
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Fick, L. J., Fick, G. H., Li, Z., Cao, E. Y., Bao, B., Heffelfinger, D., Parker, H. G., Ostrander, E. A., & Riabowol, K. T. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.11.021 · Cited by 92
Lorenz, M., Saretzki, G. C., Sitte, N., Metzkow, S., & von Zglinicki, T. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00664-5 · Cited by 85
Ducrest, A., Amacker, M., Mathieu, Y., Cuthbert, A. P., Trott, D. A., Newbold, R. F., Nabholz, M., & Lingner, J. (2001) · PubMed · Cited by 85
Dagarag, M. D., Ng, H. L., Lubong, R., Effros, R. B., & Yang, O. O. (2003) · Journal of Virology · doi:10.1128/jvi.77.5.3077-3083.2003 · Cited by 85
Fossel, M. (1998) · JAMA · doi:10.1001/jama.279.21.1732 · Cited by 86
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Hahn, W. C. (2002) · Molecules and Cells · doi:10.1016/s1016-8478(23)15045-x · Cited by 84
Ouyang, K. J., Woo, L. L., & Ellis, N. A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.003 · Cited by 90
Liu, T. M., Ng, W. M., Tan, H. S., Denslin, V., Yang, Z., Fan, J., Zou, Y. S., Hui, J. H. P., Lee, E. H., & Lim, B. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0222 · Cited by 83
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Brümmendorf, T. H., Rufer, N., Holyoake, T. L., MACIEJEWSKI, J., BARNETT, M. J., Eaves, C. J., Eaves, A. C., Young, N. S., & Lansdorp, P. M. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03598.x · Cited by 83
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Metadata
- Authors
- Vaziri, H., & Benchimol, S.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Benchimol, Samuel
- ORCID
- Benchimol, Samuel
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 1998-02
- Volume
- 8
- Issue
- 5
- Pages
- 279-282
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2100550233
- Cited by
- 1,003
- References
- 25
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 12 · 2023: 8 · 2022: 13 · 2021: 11 · 2020: 12 · 2019: 15 · 2018: 9 · 2017: 15 · 2016: 20 · 2015: 27 · 2014: 17 · 2013: 28 · 2012: 31
- FWCI
- 48.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- telomerase, hTERT, telomere length, replicative lifespan, cellular senescence, telomere maintenance, retroviral gene transfer, human diploid fibroblasts, telomeric DNA, end-replication problem
- MeSH terms
- Animals, Catalysis, Cells, Cultured, DNA Replication, DNA-Binding Proteins, Fibroblasts, Humans, Protein Conformation, Proteins, Retroviridae, RNA, Tetrahymena, Telomere, Cellular Senescence, Telomerase
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