Clathrin-mediated endocytosis: membrane factors pull the trigger
Abstract
Clathrin-mediated endocytosis is a vesicular transport event involved in the internalization and recycling of receptors participating in signal transduction events and nutrient import as well as in the reformation of synaptic vesicles. Recent studies in vitro and in living cells have provided a number of new insights into the initial steps of clathrin-coated vesicle formation and the membrane factors involved in this process. The unexpected complexity of these interactions at the cytosol-membrane interface suggests that clathrin-coated vesicle assembly is a highly cooperative process occurring under tight regulatory control. In this review, we focus on the role of membrane proteins and lipids in the nucleation of clathrin-coated pits and provide a hypothetical model for the early steps in clathrin-mediated endocytosis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Receptor-mediated endocytosis is further classified into clathrin-mediated endocytosis, caveolin-mediated endocytosis, caveolin-independent endocytosis, and clathrin-independent endocytosis.
“The receptor-mediated endocytosis has been further classified into several subtypes, such as clathrin-mediated endocytosis (CME), Caveolin-mediated endocytosis (CavME), Caveolin-independent endocytosis (CavIE), and Clathrin-independent endocytosis (CIE) [6,7,8,9].”
From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [7]
Cites
Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse
Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F., & Südhof, T. C. (1994) · Cell · doi:10.1016/0092-8674(94)90556-8 · Cited by 1,483 · see citing works
Kirchhausen, T. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.699 · Cited by 560 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hamdan, F. F., Audet, M., Garneau, P., Pelletier, J., & Bouvier, M. (2005) · SLAS Discovery · doi:10.1177/1087057105275344 · Cited by 183 · see citing works
Nesti, E., Everill, B., & Morielli, A. D. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-11-0788 · Cited by 94 · see citing works
Insights of Endocytosis Signaling in Health and Disease
Pathak, C., Vaidya, F. U., Waghela, B. N., Jaiswara, P. K., Gupta, V. K., Kumar, A., Rajendran, B. K., & Ranjan, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032971 · Cited by 59 · see citing works
“Clathrin-mediated endocytosis (CME) progress internalization of molecules by complex process signaling mechanism is coordinated by G-protein and tyrosine kinase receptors and synaptic vesicle reformation as an early endosome [7].”
Background
- Authors
- Takei, K., & Haucke, V.
- Affiliations
- Okayama University (JP)
- University of Göttingen (DE)
- Corresponding author
- Takei, Kohji
- Haucke, Volker
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2001-09
- Volume
- 11
- Issue
- 9
- Pages
- 385-391
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2026005895
- Cited by
- 311
- References
- 2
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 2 · 2022: 8 · 2021: 13 · 2020: 8 · 2019: 10 · 2018: 6 · 2017: 8 · 2016: 11 · 2015: 6 · 2014: 13 · 2013: 15 · 2012: 11
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB523)
- Ministry of Education, Culture, Sports, Science and Technology
- Verband der Chemischen Industrie
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- clathrin-mediated endocytosis, membrane proteins, membrane lipids, clathrin-coated pits, receptor internalization, vesicle recycling, signal transduction, membrane curvature
- MeSH terms
- Animals, Calcium-Binding Proteins, Carrier Proteins, Endocytosis, Membrane Glycoproteins, Membrane Lipids, Membrane Proteins, Models, Biological, Nerve Tissue Proteins, Signal Transduction, Clathrin-Coated Vesicles, Adaptor Proteins, Vesicular Transport, Synaptotagmins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
