Proteasome inhibitors: valuable new tools for cell biologists.
Abstract
Proteasomes are major sites for protein degradation in eukaryotic cells. The recent identification of selective proteasome inhibitors has allowed a definition of the roles of the ubiquitin-proteasome pathway in various cellular processes, such as antigen presentation and the degradation of regulatory or membrane proteins. This review describes the actions of these inhibitors, how they can be used to investigate cellular responses, the functions of the proteasome demonstrated by such studies and their potential applications in the future.
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MG-132 protects IκB from proteasomal degradation in inflammatory cells.
“MG-132 is known to protect IκB, which inhibits NFκB, from proteasomal degradation in inflammatory cells.”
From Proteasome dysfunction induces muscle growth defects and protein aggregation (2014) · cites this paper as Lee and Goldberg, 1998
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- Authors
- Lee, D. H., & Goldberg, A. L.
- Affiliations
- Harvard University (US)
- Corresponding author
- Goldberg, Alfred L
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 8
- Issue
- 10
- Pages
- 397-403
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W1973963032
- Cited by
- 1,474
- References
- 2
- Citations by year
- 2026: 31 · 2025: 33 · 2024: 33 · 2023: 37 · 2022: 42 · 2021: 48 · 2020: 37 · 2019: 39 · 2018: 39 · 2017: 34 · 2016: 35 · 2015: 36 · 2014: 56 · 2013: 49 · 2012: 69
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- proteasome inhibitors, proteasome, ubiquitin-proteasome system, protein degradation, antigen presentation, membrane protein degradation, cellular response
- MeSH terms
- Acetylcysteine, Animals, Boron Compounds, Cysteine Endopeptidases, Depression, Chemical, Heat-Shock Proteins, Humans, Leupeptins, Mammals, Multienzyme Complexes, Oligopeptides, Endopeptidases, Protease Inhibitors, Proteins, Sulfones, Ubiquitins, Yeasts, Antigen Presentation, Proteasome Endopeptidase Complex
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