Regulation of apoptosis by the ubiquitin and proteasome pathway

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.

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Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

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Aggresomes: A Cellular Response to Misfolded Proteins

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Aggresomes, inclusion bodies and protein aggregation

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Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

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Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

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The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

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Proteasome inhibitors: valuable new tools for cell biologists.

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Proteasome inhibitors: a novel class of potent and effective antitumor agents.

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Proteasome inhibitors: from research tools to drug candidates.

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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

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A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly

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Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

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Cellular Defenses against Unfolded Proteins

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Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

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Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

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A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

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Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells

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The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis

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A proteasome inhibitor prevents activation of NF‐kappa B and stabilizes a newly phosphorylated form of I kappa B‐alpha that is still bound to NF‐kappa B.

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A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

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Proteasome from Thermoplasma acidophilum : a Threonine Protease

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Regulation of ubiquitin‐dependent processes by deubiquitinating enzymes

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CHIP is a chaperone‐dependent E3 ligase that ubiquitylates unfolded protein

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A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes.

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Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition.

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The Proteasome, a Novel Protease Regulated by Multiple Mechanisms

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Dynamic Association of Proteasomal Machinery with the Centrosome

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

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The Ubiquitin-related BAG-1 Provides a Link between the Molecular Chaperones Hsc70/Hsp70 and the Proteasome

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The Regulatory Particle of the Saccharomyces cerevisiae Proteasome

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Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.

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c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma Cells

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The multicatalytic proteinase complex, a major extralysosomal proteolytic system

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Ubiquitin in chains

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

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Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin–proteasome degradation

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Structure of a Bag/Hsc70 Complex: Convergent Functional Evolution of Hsp70 Nucleotide Exchange Factors

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THE PROTEASOME

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p53-Dependent apoptosis pathways

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Identity of the 19S 'prosome' particle with the large multifunctional protease complex of mammalian cells (the proteasome)

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Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids

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The role of the ubiquitin-proteasome pathway in apoptosis

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Purification of an 11 S regulator of the multicatalytic protease.

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Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

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A Giant Protease with Potential to Substitute for Some Functions of the Proteasome

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Evidence that Pituitary Cation‐Sensitive Neutral Endopeptidase Is a Multicatalytic Protease Complex

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Deadly encounter: ubiquitin meets apoptosis

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Roles of ubiquitin-mediated proteolysis in cell cycle control

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Lovastatin-mediated G 1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase

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Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts

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Enhancement of radiosensitivity by proteasome inhibition: Implications for a role of NF-κB

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Cation‐Sensitive Neutral Endopeptidase: Isolation and Specificity of the Bovine Pituitary Enzyme

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Structure and Anticoagulant Activity of a Fucosylated Chondroitin Sulfate from Echinoderm

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Proteasomes play an essential role in thymocyte apoptosis.

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Catalytic Activities of the 20 S Proteasome, a Multicatalytic Proteinase Complex

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An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses

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26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer

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A Giant Ubiquitin-conjugating Enzyme Related to IAP Apoptosis Inhibitors

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Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts.

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Displacement of housekeeping proteasome subunits by MHC‐encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex.

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Intracellular Localization of Proteasomal Degradation of a Viral Antigen

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Chemosensitization of Pancreatic Cancer by Inhibition of the 26S Proteasome

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Lactacystin, a Specific Inhibitor of the Proteasome, Induces Apoptosis in Human Monoblast U937 Cells

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p53‐inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG‐1

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The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-α-initiated apoptosis

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Growth Retardation in Mice Lacking the Proteasome Activator PA28γ

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Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53

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Activity and Regulation of the Centrosome-associated Proteasome

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Proteolysis: The proteasome: a protein-degrading organelle?

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Eponemycin exerts its antitumor effect through the inhibition of proteasome function.

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The Role of NF-κB in TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis of Melanoma Cells

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Mechanisms of tolvaptan-induced toxicity in HepG2 cells

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PSMC5 insufficiency and P320R mutation impair proteasome function

Yu, Z.-Q., Carmichael, J., Collins, G. A., D'Agostino, M. D., Lessard, M., Firth, H. V., Harijan, P., Fry, A. E., Dean, J., Zhang, J., et al. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae085 · Cited by 4 · see citing works

Dissecting Intracellular Proteolysis Using Small Molecule Inhibitors and Molecular Probes

Ovaa, H., Overkleeft, H. S., Kessler, B. M., & Ploegh, H. L. (2005) · doi:10.1002/9783527620210.ch3 · Cited by 2 · see citing works

Dissecting Intracellular Proteolysis Using Small Molecule Inhibitors and Molecular Probes

Ovaa, H., Overkleeft, H. S., Kessler, B. M., & Ploegh, H. L. (2007) · doi:10.1002/9783527619320.ch3a

Regulation of proteolysis

Attaix, D., Combaret, L., Pouch-Pélissier, M.-N., & Taillandier, D. (2001) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200101000-00009 · Cited by 74 · see citing works

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

Lüthi, A. U., Cullen, S. P., McNeela, E. A., Duriez, P. J., Afonina, I. S., Sheridan, C., Brumatti, G., Taylor, R. C., Kersse, K., Vandenabeele, P., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.007 · Cited by 677 · see citing works

Activation and Function of Caspases in Apoptosis

Chang, Y. (2002)