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Searching for a function for nuclear actin
Open accessAbstract
The abundant cytoskeletal protein actin has numerous cytoplasmic roles. Although there are many reports of the presence of actin in the nucleus, in general they have been discounted as artifactual. However, recent work has begun to provide evidence for important roles for actin in nuclear processes ranging from chromatin remodelling to splicing. In addition, several regulators of actin polymerization are localized to the nucleus or translocate to the nucleus in a regulated manner, suggesting that there is some function of actin in the nucleus that is subject to regulation. This review discusses the evidence for actin in the nucleus and summarizes recent work suggesting that actin or actin-related proteins are involved in the regulation of nuclear processes such as chromatin remodelling.
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Citations
Cited by
Dynamics of Single mRNPs in Nuclei of Living Cells
Shav-Tal, Y., Darzacq, X., Shenoy, S. M., Fusco, D., Janicki, S. M., Spector, D. L., & Singer, R. H. (2004) · Science · doi:10.1126/science.1099754 · Cited by 494
Irvine, R. F. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1100 · Cited by 406
Thymosin β: actin-sequestering protein moonlights to repair injured tissues
GOLDSTEIN, A., HANNAPPEL, E., & KLEINMAN, H. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.07.004 · Cited by 250
Metadata
- Authors
- Rando, O. J., Zhao, K., & Crabtree, G. R.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 10
- Issue
- 3
- Pages
- 92-97
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2070976067
- Cited by
- 231
- References
- 0
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rando, O. J., Zhao, K., & Crabtree, G. R. (2000). Searching for a function for nuclear actin. Trends in Cell Biology. https://doi.org/10.1016/s0962-8924(99)01713-4
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