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Dbl family guanine nucleotide exchange factors

Zheng, Yi·2001·Trends in Biochemical Sciences
DOI 10.1016/s0968-0004(01)01973-9
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Abstract

The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals leading to the activation of Rho GTPases. The tandem Dbl-homology and pleckstrin-homology domains shared by all members of this family represent the structural module responsible for catalyzing the GDP-GTP exchange reaction of Rho proteins. Recent progress in genomic, genetic, structural and biochemical studies has implicated Dbl family members in diverse biological processes, including growth and development, skeletal muscle formation, neuronal axon guidance and tissue organization. The detailed pictures of their autoregulation, agonist-controlled activation and mechanism of interaction with Rho GTPase substrates, have begun to emerge.

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Citations

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Research works printed but not linked: 62

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Cited by

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Metadata

Authors
Zheng, Y.
Venue
Trends in Biochemical Sciences
Publisher
Elsevier BV
Published
2001-12
Volume
26
Issue
12
Pages
724-732
ISSN
0968-0004
DOI
10.1016/s0968-0004(01)01973-9
Cited by
339
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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