Cited by 160Neuroscience and Neuropharmacology ResearchAxon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Signaling mechanisms underlying dendrite formation

Miller, Freda D, Kaplan, David R·2003·Current Opinion in Neurobiology

Abstract

During development, the nervous system is confronted with a problem of enormous complexity; to progress from a large number of 'disconnected' neurons to a network of neuronal circuitry that is able to dynamically process sensory information and generate an appropriate output. To form these circuits, growing axons must make synapses with targets, usually the dendrites of postsynaptic neurons. Although a significant amount is known about the signals that regulate and guide developing axons, we are only now starting to understand how environmental cues like growth factors and activity regulate the formation and maintenance of dendrites in the developing and mature nervous system.

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Crossref · 10.1016/s0959-4388(03)00072-2

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65 of 65 references verified0 citation errors · 0 not checkable

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Authors
Miller, F. D., & Kaplan, D. R.
Affiliations
Hospital for Sick Children (CA)
Corresponding author
Miller, Freda D
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2003-06
Volume
13
Issue
3
Pages
391-398
ISSN
0959-4388 (ISSN-L)
OpenAlex
W1984418778
Cited by
160
References
66
Citations by year
2025: 1 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 9 · 2012: 11
FWCI
1.55
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
dendrite formation, neural circuit formation, axon guidance, synaptogenesis, growth factors, neuronal activity, postsynaptic neurons, brain development
MeSH terms
Animals, Dendrites, Humans, Signal Transduction

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