RNA, the first macromolecular catalyst: the ribosome is a ribozyme

The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution

Ban, N., Nissen, P., Hansen, J., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.905 · Cited by 3,327

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., & Altman, S. (1983) · Cell · doi:10.1016/0092-8674(83)90117-4 · Cited by 2,684

The Structural Basis of Ribosome Activity in Peptide Bond Synthesis

Nissen, P., Hansen, J., Ban, N., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.920 · Cited by 2,269

Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit

Ogle, J. M., Brodersen, D. E., Clemons, W. M., Tarry, M. J., Carter, A. P., & Ramakrishnan, V. (2001) · Science · doi:10.1126/science.1060612 · Cited by 1,162

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

Schlünzen, F., Zarivach, R., Harms, J., Bashan, A., Tocilj, A., Albrecht, R., Yonath, A., & Franceschi, F. J. (2001) · Nature · doi:10.1038/35101544 · Cited by 1,057

A SMALL PARTICULATE COMPONENT OF THE CYTOPLASM

Palade, G. E. (1955) · The Journal of Cell Biology · doi:10.1083/jcb.1.1.59 · Cited by 1,014

High Resolution Structure of the Large Ribosomal Subunit from a Mesophilic Eubacterium

Harms, J. M., Schluenzen, F., Zarivach, R., Bashan, A., Gat, S., Agmon, I., Bartels, H., Franceschi, F. J., & Yonath, A. (2001) · Cell · doi:10.1016/s0092-8674(01)00546-3 · Cited by 899

In vitro splicing of the ribosomal RNA precursor of tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequence

Cech, T. R., Zaug, A. J., & Grabowski, P. J. (1981) · Cell · doi:10.1016/0092-8674(81)90390-1 · Cited by 879

The kink‐turn: a new RNA secondary structure motif

Klein, D. J., Schmeing, T. M., Moore, P. B., & Steitz, T. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.15.4214 · Cited by 740

RNA tertiary interactions in the large ribosomal subunit: The A-minor motif

Nissen, P., Ippolito, J. A., Ban, N., Moore, P. B., & Steitz, T. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081082398 · Cited by 659

Recombination: RNA — A Powerful Tool for Recombination and Regulated Expression of Genes

Müller, D., & Ståhl, U. (2005) · Springer eBooks · doi:10.1007/3-540-27043-4_2 · Cited by 3

A Determination of the Identity Elements in Yeast 18 S Ribosomal RNA for the Recognition of Ribosomal Protein YS11: The Role of the Kink–Turn Motif in Helix 11

Dresios, J., Chan, Y., & Wool, I. G. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.10.027 · Cited by 3

Computationally-guided design and selection of ribosomal active site mutants with high activityPreprint

Kofman, C., Watkins, A. M., Kim, D. S., Wooldredge, A. C., Karim, A. S., Das, R., & Jewett, M. C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.02.493746 · Cited by 3

A Novel Actinobacteria-Specific Ribosome Hibernation Factor in Mycobacterium tuberculosisPreprint

Majumdar, S., Li, Y., Manjari, S. R., Gamper, H., Hou, Y., Banavali, N. K., Ojha, A. K., & Agrawal, R. K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.25.625233 · Cited by 3

Quantifying the Evolution of SNPs That Affect RNA Secondary Structure in Arabidopsis thaliana Genes

Martin, G. T., Fiscus, C. J., & Gaut, B. S. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msaf126 · Cited by 2

Water and the Origin of Life

Henry, M. (2024) · Water · doi:10.3390/w16192854 · Cited by 3

The Old and New RNA World

Szweykowska-Kulińska, Z. (2014) · Acta Societatis Botanicorum Poloniae · doi:10.5586/asbp.2014.035 · Cited by 2

The Cech Symposium: A celebration of 25 years of ribozymes, 10 years of TERT, and 60 years of Tom

Vicens, Q., Allen, M. A., Gilbert, S. D., Reznik, B. N., Gooding, A. R., & Batey, R. (2008) · RNA · doi:10.1261/rna.910008 · Cited by 2

Recent advances in the characterization of peptidyl transferase center: zero-distance labeling of proteins at or near the catalytic site of human 80S or Escherichia coli 70S ribosomes by means of periodate-oxidized tRNA

Baouz, S., Woisard, A., Chenoune, L., Aguié, G., Keith, G., Schmitter, J., Caër, J. L., & Hountondji, C. (2009) · HAL · Cited by 2

Branching Processes in the Compartment Model of RNA World

Myszor, D., & Cyran, K. A. (2011) · Advances in intelligent and soft computing · doi:10.1007/978-3-642-23169-8_17 · Cited by 2

Coenzyme und ihre Rolle in der Evolution des Lebens

Kirschning, A. (2020) · Angewandte Chemie · doi:10.1002/ange.201914786 · Cited by 3

Aminoglycoside Antibiotics

Kirst, H. A., & Allen, N. E. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.02685-8 · Cited by 2

Study of RNA–Protein Interactions and RNA Structure in Ribonucleoprotein Particles (RNPs)

Marchand, V., Mougin, A., Méreau, A., Behm‐Ansmant, I., Motorin, Y., & Branlant, C. (2014) · Wiley eBooks · doi:10.1002/9783527647064.ch44 · Cited by 2

From Molecular Evolution to Cellular Life

Lehto, K. M. (2007) · Wiley eBooks · doi:10.1002/9783527618996.ch4 · Cited by 2

Three phases in the evolution of the standard genetic code: how translation could get startedPreprint

van der Gulik, P. T. S. (2007) · arXiv (Cornell University) · doi:10.48550/arxiv.0711.0700 · Cited by 2

Enzyme Activities

Shyu, D. J. H., Tzen, J. T. C., & Jeang, C.-L. (2006) · doi:10.1002/9780470277577.ch7 · Cited by 2

Study of RNA–Protein Interactions and RNA Structure in Ribonucleoprotein Particles

Marchand, V., Mougin, A., Méreau, A., & Branlant, C. (2005) · Wiley eBooks · doi:10.1002/9783527619504.ch11 · Cited by 3

The translating bacterial ribosome at 1.55 Å resolution by open access cryo-EMPreprint

Fromm, S. A., O’Connor, K. M., Purdy, M. D., Bhatt, P. R., Loughran, G., Atkins, J. F., Jomaa, A., & Mattei, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.30.505838 · Cited by 2

Ambient Temperature Bacterial Large Ribosomal Subunit Structure Enabled by Serial Femtosecond X-ray CrystallographyPreprint

Tosun, B., Rao, Y., Destan, E., Dao, E. H., Ertem, F. B., Yilmaz, M., Yapici, İ., Gül, M., Ayan, E. B., Johnson, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.24.563633 · Cited by 2

From the RNA world to the DNA-protein world: clues to the origin and early evolution of life in the ribosome

Meléndez‐Hevia, E. (2009) · Journal of Biosciences · doi:10.1007/s12038-009-0095-2 · Cited by 1

New method to predict conserved RNA structures

Mironov, A. A. (2007) · Molecular Biology · doi:10.1134/s0026893307040188 · Cited by 1

Hipotetyczna rola autokatalitycznych właściwości kwasów nukleinowych w procesie biogenezy

Adamala, K. P., & Pikuła, S. (2004) · Cited by 1

Zitronensäure und die RNA‐Welt

Müller, U. F., & Tor, Y. (2014) · Angewandte Chemie · doi:10.1002/ange.201400847 · Cited by 1

Continuous In Vitro evolution of a ribozyme ligase: A model experiment for the evolution of a biomolecule

Ledbetter, M. P., Hwang, T. W., Stovall, G. M., & Ellington, A. D. (2013) · Biochemistry and Molecular Biology Education · doi:10.1002/bmb.20742 · Cited by 1

Contributions of Large-Scale DNA Sequencing Efforts to the Understanding of Low Temperature Piezophiles

Bartlett, D. H., & Kerman, I. (2010) · Springer eBooks · doi:10.1007/978-4-431-53898-1_33 · Cited by 1

Influence of Introduction of Mitosis-Like Processes into Mathematical-Simulation Model of Protocells in RNA World

Myszor, D. (2015) · Advances in intelligent systems and computing · doi:10.1007/978-3-319-23437-3_22 · Cited by 1

The Origin of Life Discovered: ��RNA

Zhou, M. (2018) · OALib · doi:10.4236/oalib.1104681 · Cited by 1

The Plethora of RNA–Protein Interactions Model a Basis for RNA Therapies

Dansereau, S. J., Cui, H. L., Dartawan, R., & Sheng, J. (2025) · Genes · doi:10.3390/genes16010048 · Cited by 1

RNAprecis: Prediction of full-detail RNA conformation from the experimentally best-observed sparse parameters

Wiechers, H., Williams, C. J., Eltzner, B., Hoppe, F., Prisant, M. G., Chen, V. B., Miller, E., Mardia, K. V., Richardson, J. S., & Huckemann, S. (2026) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1014242 · Cited by 1

Physical basis of space environment and extraterrestrial life

Farooq, H. M. U., Xuechao, L., Zhao, X., Chen, Z. P., & Qian, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36338-2.00008-0 · Cited by 1

Ancestry of RNA/RNA interaction regions within segmented ribosomes

Rivas, M., & Fox, G. E. (2023) · RNA · doi:10.1261/rna.079654.123 · Cited by 1

PlasmodiumRibosomes and Opportunities for Drug Intervention

Sharma, I., & McCutchan, T. F. (2014) · ASM Press eBooks · doi:10.1128/9781555817558.ch18 · Cited by 1

The Lipid-RNA WorldPreprint

Mallik, S., & Kundu, S. (2012) · arXiv (Cornell University) · doi:10.48550/arxiv.1211.0413 · Cited by 6

Modular Organization and Composability of RNA

Lee, M. T. S. (2009) · ScholarlyCommons (University of Pennsylvania) · Cited by 1

Nuclear Magnetic Resonance of Large Molecules in Natural Products

Wunderlich, C. H., Grutsch, S., Tollinger, M., & Kreutz, C. (2014) · Encyclopedia of Analytical Chemistry · doi:10.1002/9780470027318.a9915 · Cited by 1

The cosmological model of eternal inflation and the transition from chance to biological evolution in the history of life: The possibility of chance emergence of the replication and translation systems, and the protein superfoldsPreprint

Koonin, E. V. (2007) · arXiv (Cornell University) · doi:10.48550/arxiv.q-bio/0701023 · Cited by 1

Comparative analysis of piezophilic bacteria : the search for adaptations to life in the deep sea

Kerman, I. (2008) · eScholarship (California Digital Library) · Cited by 1

Structural studies of E. coli ribosomes by spectroscopic techniques: A specialized review

Bonicontro, A., & Risuleo, G. (2005) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2005.04.032 · Cited by 1

Is the Spliceosome a Ribozyme?

Sashital, D. G., & Butcher, S. E. (2007) · Royal Society of Chemistry eBooks · doi:10.1039/9781847557988-00253 · Cited by 1

Study on the Function of Translation Initiation Factor IF1

Croitoru, V. (2006) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1

Enzyme Activities

Shyu, D. J. H., Tzen, J. T. C., & Jeang, C.-L. (2012) · doi:10.1002/9781118308035.ch8 · Cited by 1

Enzyme

Cornish-Bowden, A. J., & Cárdenas, M. L. (2014) · Encyclopedia of Astrobiology · doi:10.1007/978-3-642-27833-4_525-2 · Cited by 1

Ribozyme Mechanisms

Hsieh, J., & Fierke, C. A. (2004) · Encyclopedia of Biological Chemistry · doi:10.1016/b0-12-443710-9/00077-6 · Cited by 1

Ribosomal RNA Processing

Dalal, J. S., & Lyons, S. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00184-x · Cited by 1

Pathways of Early Evolution From the Perspectives of a Riboreplisome – The Ultimate RNA Machine of LifePreprint

Shirokikh, N. E. (2023) · Preprints.org · doi:10.20944/preprints202305.0415.v1 · Cited by 1

Organic chemistry and biological systems. Biochemistry

Lotti, M. (2006) · BOA (University of Milano-Bicocca)

MECHANISM OF RNA REMODELING BY DEAD-BOX HELICASES

Yang, Q. (2007) · OhioLink ETD Center (Ohio Library and Information Network)

MOLECULAR RECOGNITION PROPERTIES AND KINETIC CHARACTERIZATION OF TRANS EXCISION-SPLICING REACTION CATALYZED BY A GROUP I INTRON-DERIVED RIBOZYME

Sinha, J. (2006) · UKnowledge (University of Kentucky)

Novel Algorithms for Structural Alignment of Non-coding RNAs

Kolbe, D. L. (2010) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7cr5rc5

RNA in Formation : Computational Studies on RNA Structure and Evolution

Smit, S. (2008) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)

IN VITRO AND IN VIVO CHARACTERIZATION OF A TRANS EXCISION-SPLICING RIBOZYME

Nusbaum, C. (2005) · UKnowledge (University of Kentucky)

RNA Stability: Chemistry, Measurement and Modulation

McDowall, K. J. (2008) · Wiley Encyclopedia of Chemical Biology · doi:10.1002/9780470048672.wecb521

Engineering RNA-Based Circuits

Narayanaswamy, R., & Ellington, A. D. (2006) · Springer eBooks · doi:10.1007/3-540-27262-3_22 · Cited by 1

Single-Molecule Studies Of Local And Global Nucleic-Acid Dynamics

Patrick, E. M. (2013) · Human Biology

Physico-chemical characterization of beta-amyloid oligomers and study of their function in biological processes at molecular level

Simon, D. (2011) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.1292

Cardiomyocyte Apoptosis Were Inhibited by Anti-Fas Ribozyme

Zhu, X., Zheng, S., Jiang, D., & Ge, J.-F. (2010) · International Conference on Bioinformatics and Biomedical Engineering · doi:10.1109/icbbe.2010.5514718

Are Molecular Alphabets Universal Enabling Factors for the Evolution of Complex Life?

Dunn, I. S. (2013) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-014-9354-9

The role of VPg in translation of calicivirus RNA

Daughenbaugh, K. F. (2005)

Structural and Genetic Studies of Translation in Escherichia coli

Zhao, Q. H. (2005) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

On bacterial formats in protein library technology

Löfdahl, P. (2009) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Involvements of the Plant 3'-5' Exonuclease ERL1 in Chloroplast Ribosomal RNA Biogenesis and RNA Silencing Pathways

Schumacher, H. T. (2009) · Kobra (Universitätsbibliothek Kassel)

Structural Analysis of the 50S Ribosomal Stalk

Diaconu, M. (2007) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-214

Alternative splicing of an ORF-less group II intron in Clostridium tetani

McNeil, B. A. (2013) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/24779

Biochemical and MALDI-MS Methods for Characterization of Ribosomal Proteins

Hamburg, D.-M. (2008) · OhioLink ETD Center (Ohio Library and Information Network)

Structural studies on prokaryotic RNA-binding proteins.

Dg, W. (2006) · OpenGrey (Institut de l'Information Scientifique et Technique)

Evolution of tRNAs Was Driven by Entropic Forces

José, M. V., Zamudio, G. S., & de Farías, S. T. (2016) · Springer eBooks · doi:10.1007/978-3-319-39468-8_1

Performing Collective Tasks with Flagellated Bacteria Acting as Natural and Hybrid Microrobots

Martel, S. M. (2013) · doi:10.1201/b14908-27

UNDERSTANDING THE ROLE OF RIBOSOMAL PROTEINS AND FLVCR1 ABERRANT SPLICING IN DIAMOND BLACKFAN ANEMIA

Fernandes, A. B. (2012)

RNA interaction studies : a pathway to the development of a surface-based technology

Phillips, J. O. (2016)

Development of In Vivo Systems for Detecting and Studying Ribosome Inhibition by Small Molecules

Huang, S. (2016) · UNM’s Digital Repository (University of New Mexico)

Studying Parasite Gene Function and Interaction Through Ribozymes and Riboswitches Design Mechanism

Shukla, H., & Tripathi, T. (2018) · Springer eBooks · doi:10.1007/978-981-10-8693-9_4

The Lipid-RNA World: A Membrane Bound Origin of RibosomePreprint

Mallik, S., & Kundu, S. (2012) · arXiv (Cornell University)

Untersuchung des katalytischen Mechanismus der RNase P: die Rolle für die Katalyse wichtiger divalenter Metallionen und funktioneller Gruppen

Cuzic‐Feltens, S. (2006) · Publikationsserver (Universitat Marburg) · doi:10.17192/z2006.0096

Non-protein-coding RNA : Transcription and regulation of ribosomal RNA

Böhm, S. (2014) · DiVA (Stockholm University)

Optimierung der Expressionsstärke von fremdstoffmetabolisierenden Enzymen in Bakterien und permanenten Zellkulturen für toxikologische Untersuchungen

Osterloh‐Quiroz, M. (2006) · publish.UP (University of Potsdam)

Свойства и функции мотива А-минор, наиболее распространенного мотива структуры РНК

Baulin, E. F. (2021) · Biochemistry (Moscow) · doi:10.31857/s0320972521080078

COVID-19: Mechanisms of the Antiviral Activities of Selective Antibiotics Targeting the Human 80S Ribosome

Hountondji, C., Poupaert, J. H., Aguida, B., Saga, F. K. A., Pothier, J. F., Créchet, J., Cocks, C., Barty, L., KASSEHIN, U. C., & Gbaguidi, F. A. (2021) · The Open Biochemistry Journal · doi:10.2174/1874091x02115010038

Bacteriophages and viruses (not alive, but important)

Graves, J. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822105-1.00012-3

References

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Regulation of glucosamine-6-phosphate synthase synthesis by a hierarchical acting cascade composed of two small regulatory RNAs in Escherichia coli.

Reichenbach, B. (2010) · doi:10.53846/goediss-352

Analysis of translational fidelity in cellular proteins

Garofalo, R. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7371

Faculty Opinions recommendation of Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.

Unrau, P. J. (2005) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1008763.341205

Isolation and characterization of the U4 snRNP in Saccharomyces cerevisiae.

de la Giroday, H. (2008) · doi:10.24124/2008/bpgub573

RNA World

Horning, D. P. (2015) · Encyclopedia of Astrobiology · doi:10.1007/978-3-662-44185-5_1740

RNA World

Horning, D. P. (2014) · Encyclopedia of Astrobiology · doi:10.1007/978-3-642-27833-4_1740-2

ycil, yfgB, ygdP, and ybcJ are novel genes that affect the process of protein synthesis in Escherichia coli

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RNA

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Faculty Opinions recommendation of Crystal structure of Pistol, a class of self-cleaving ribozyme.

Lilley, D. M. J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727215310.793563684

Enzyme

Cornish-Bowden, A. J., & Cárdenas, M. L. (2015) · Encyclopedia of Astrobiology · doi:10.1007/978-3-662-44185-5_525

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Proteína inactivadora de los ribosomas de Streptomyces coelicolor

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Regulación de la expresión génica en respuesta a insulina en las distintas partes del eje embrionario de maíz (Zea mays L.) durante la germinación

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The Much-Awaited Bridge: Connecting the Worlds of RNA Biology and Glycobiology Through the Discovery of Glycornas

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On the structural basis of peptide‐bond formation and antibiotic resistance from atomic structures of the large ribosomal subunit

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Inhibitors of the Large Ribosomal Subunit from Haloarcula marismortui

Moore, P. B. (2010) · Israel Journal of Chemistry · doi:10.1002/ijch.201000001 · Cited by 2

The Ribosome at Atomic Resolution

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Current Topics

At, T. R., & Moore, P. B. (2007)

The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution

Ban, N., Nissen, P., Hansen, J., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.905 · Cited by 3,327