Steitz, Thomas A.

The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution

Ban, N., Nissen, P., Hansen, J., Moore, P. B., & Steitz, T. A. (2000) · Science

RNA and protein synthesis mechanismsEnzyme Structure and Function

Cited by 3,327

The Structural Basis of Ribosome Activity in Peptide Bond Synthesis

Nissen, P., Hansen, J., Ban, N., Moore, P. B., & Steitz, T. A. (2000) · Science

RNA and protein synthesis mechanismsRNA modifications and cancer

Cited by 2,269

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., & Steitz, T. A. (1992) · Science

HIV/AIDS drug development and treatmentEnzyme Structure and Function

Cited by 1,914

A general two-metal-ion mechanism for catalytic RNA

Steitz, T. A., & Steitz, J. A. (1993) · Proceedings of the National Academy of Sciences

RNA and protein synthesis mechanismsPhysical Organic Chemistry and Reaction Kinetics

Cited by 1,171

DNA Polymerases: Structural Diversity and Common Mechanisms

Steitz, T. A. (1999) · Journal of Biological Chemistry

Enzyme Structure and FunctionDNA Repair Mechanisms

Cited by 848

Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes

Brautigam, C. A., & Steitz, T. A. (1998) · Current Opinion in Structural Biology

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 377

RNA, the first macromolecular catalyst: the ribosome is a ribozyme

Steitz, T. A., & Moore, P. B. (2003) · Trends in Biochemical Sciences

RNA and protein synthesis mechanismsRNA modifications and cancer

Cited by 319

Revisiting the structures of several antibiotics bound to the bacterial ribosome

Bulkley, D., Innis, C. A., Blaha, G., & Steitz, T. A. (2010) · Proceedings of the National Academy of Sciences

RNA and protein synthesis mechanismsMicrobial Natural Products and Biosynthesis

Cited by 308

A Unified Polymerase Mechanism for Nonhomologous DNA and RNA Polymerases

Steitz, T. A., Smerdon, S. J., Jäger, J., & Joyce, C. M. (1994) · Science

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 280

Recombining the structures of HIV integrase, RuvC and RNase H

Yang, W., & Steitz, T. A. (1995) · Structure

Enzyme Structure and FunctionHIV/AIDS drug development and treatment

Cited by 246

Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer

Wang, J., Smerdon, S. J., Jäger, J., Kohlstaedt, L. A., Rice, P. A., Friedman, J. M., & Steitz, T. A. (1994) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 175

Crystal Structures of an NH2-Terminal Fragment of T4 DNA Polymerase and Its Complexes with Single-Stranded DNA and with Divalent Metal Ions

Wang, J., Yu, P., Lin, T. C., Konigsberg, W. H., & Steitz, T. A. (1996) · Biochemistry

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 99

Mutations outside the anisomycin-binding site can make ribosomes drug-resistant

Blaha, G., Gürel, G., Schroeder, S. J., Moore, P. B., & Steitz, T. A. (2008) · Journal of Molecular Biology

RNA and protein synthesis mechanismsRNA modifications and cancer

Cited by 88

Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA

Polikanov, Y. S., Szal, T., Jiang, F., Gupta, P., Matsuda, R., Shiozuka, M., Steitz, T. A., Vázquez-Laslop, N., & Mankin, A. S. (2014) · Molecular Cell

RNA and protein synthesis mechanismsRNA modifications and cancer

Cited by 57