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RNA, the first macromolecular catalyst: the ribosome is a ribozyme
Abstract
Recently, the atomic structures of the large ribosomal subunit from Haloarcula marismortui and its complexes with substrates have been determined. These have provided exciting new insights into the principles of RNA structure, the mechanism of the peptidyl-transferase reaction and early events in the evolution of this RNA-protein complex assembly that is essential in all cells. The structures of the large subunit bound to a variety of antibiotics explain the effects of antibiotic resistance mutations and provide promise for the development of new antibiotics.
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“The central role of RNA in modern cellular biochemistry, and especially the role of the large ribosomal RNA as the catalyst of protein synthesis (Steitz and Moore 2003), provides a powerful argument in support of RNA as the dominant genetic and functional biopolymer at an early stage in the evolution of life.”
From Protocells and RNA Self-Replication (2018) · cites this paper as Steitz and Moore 2003
Citations
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Metadata
- Authors
- Steitz, T. A., & Moore, P. B.
- Affiliations
- Howard Hughes Medical Institute (US)
- Yale University (US)
- Corresponding author
- Steitz, Thomas A
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 28
- Issue
- 8
- Pages
- 411-418
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2162522101
- Cited by
- 319
- References
- 36
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 7 · 2023: 10 · 2022: 7 · 2021: 8 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 10 · 2016: 13 · 2015: 10 · 2014: 20 · 2013: 10 · 2012: 15
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agouron Institute
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Keywords
- ribosome, ribozymes, peptidyl transferase, RNA catalysis, large ribosomal subunit, Haloarcula marismortui, antibiotic resistance, antibiotic binding sites, RNA structure
- MeSH terms
- Drug Resistance, Microbial, Microscopy, Electron, Models, Chemical, Models, Molecular, Nucleic Acid Conformation, Peptide Elongation Factor Tu, Peptidyl Transferases, Protein Binding, Ribosomes, RNA, RNA, Messenger, RNA, Ribosomal, 23S, RNA, Transfer, RNA, Catalytic, Haloarcula marismortui
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