Synthetic biology

A synthetic oscillatory network of transcriptional regulators

Elowitz, M., & Leibler, S. (2000) · Nature · doi:10.1038/35002125 · Cited by 4,812 · see citing works

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

Martin, V. J. J., Pitera, D. J., Withers, S. T., Newman, J. D., & Keasling, J. D. (2003) · Nature Biotechnology · doi:10.1038/nbt833 · Cited by 1,720 · see citing works

Synthesizing life

Szostak, J. W., Bartel, D. P., & Luisi, P. L. (2001) · Nature · doi:10.1038/35053176 · Cited by 1,681 · see citing works

The thermodynamics of DNA structural motifs.

SantaLucia, J., & Hicks, D. (2004) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.32.110601.141800 · Cited by 1,302 · see citing works

The Nature of a Paradigm

Masterman, M. (1970) · Criticism and the Growth of Knowledge · doi:10.1017/cbo9781139171434.008 · Cited by 1,015 · see citing works

Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template.

Cello, J., Paul, A. V., & Wimmer, E. (2002) · Science · doi:10.1126/science.1072266 · Cited by 980 · see citing works

Global Transposon Mutagenesis and a Minimal Mycoplasma Genome

Hutchison, C. A., Peterson, S. N., Gill, S. R., Cline, R. T., White, O. R., Fraser, C. M., Smith, H. O., & Venter, J. C. (1999) · Science · doi:10.1126/science.286.5447.2165 · Cited by 925 · see citing works

Disappearing Polymorphs

Dunitz, J. D., & Bernstein, J. (1995) · Accounts of Chemical Research · doi:10.1021/ar00052a005 · Cited by 847 · see citing works

Engineered gene circuits

Hasty, J., McMillen, D. R., & Collins, J. J. (2002) · Nature · doi:10.1038/nature01257 · Cited by 744 · see citing works

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

Freier, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.22.4429 · Cited by 692 · see citing works

Design of Folded Peptides

Venkatraman, J., Shankaramma, S. C., & Balaram, P. (2001) · Chemical Reviews · doi:10.1021/cr000053z · Cited by 689 · see citing works

Borate Minerals Stabilize Ribose

Ricardo, A., Carrigan, M. A., Olcott, A. N., & Benner, S. A. (2004) · Science · doi:10.1126/science.1092464 · Cited by 646 · see citing works

A deoxyribozyme-based molecular automaton

Stojanović, M. N., & Stefanović, D. (2003) · Nature Biotechnology · doi:10.1038/nbt862 · Cited by 624 · see citing works

Chemical etiology of nucleic acid structure

Eschenmoser, A. (1999) · Science · doi:10.1126/science.284.5423.2118 · Cited by 611 · see citing works

Integration of Multiple Signals Through Cooperative Regulation of the N-WASP-Arp2/3 Complex

Prehoda, K. E., Scott, J. A., Mullins, R. D., & Lim, W. A. (2000) · Science · doi:10.1126/science.290.5492.801 · Cited by 524 · see citing works

Z-DNA: the long road to biological function

Rich, A., & Zhang, S.-G. (2003) · Nature reviews genetics · doi:10.1038/nrg1115 · Cited by 500 · see citing works

Atomic Coordinates and Structure Factors for Two Helical Configurations of Polypeptide Chains

Pauling, L. C., & Corey, R. B. (1951) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.37.5.235 · Cited by 422 · see citing works

Combinatorial and computational challenges for biocatalyst design

Arnold, F. H. (2001) · Nature · doi:10.1038/35051731 · Cited by 414 · see citing works

Understanding Nucleic Acids Using Synthetic Chemistry

Benner, S. A. (2004) · Accounts of Chemical Research · doi:10.1021/ar040004z · Cited by 377 · see citing works

Rewiring MAP Kinase Pathways Using Alternative Scaffold Assembly Mechanisms

Park, S.-H., Zarrinpar, A., & Lim, W. A. (2003) · Science · doi:10.1126/science.1076979 · Cited by 355 · see citing works

A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides.

Tabor, S., & Richardson, C. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.14.6339 · Cited by 350 · see citing works

Introduction to Artificial Life

Adami, C. (1998) · doi:10.1007/978-1-4612-1650-6 · Cited by 345 · see citing works

Rates of decomposition of ribose and other sugars - implications for chemical evolution

Larralde, R., Robertson, M. P., & Miller, S. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8158 · Cited by 344 · see citing works

The Structure of Scientific Revolutions.

Barber, B., & Kuhn, T. S. (1963) · American Sociological Review · doi:10.2307/2090620 · Cited by 343 · see citing works

Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)

Wengel, J. (1998) · Accounts of Chemical Research · doi:10.1021/ar980051p · Cited by 335 · see citing works

A branched DNA signal amplification assay for quantification of nucleic acid targets below 100 molecules/ml

Collins, M. L. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.15.2979 · Cited by 319 · see citing works

RNA, the first macromolecular catalyst: the ribosome is a ribozyme

Steitz, T. A., & Moore, P. B. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00169-5 · Cited by 319 · see citing works

De novo design of catalytic proteins

Kaplan, J. H., & DeGrado, W. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404387101 · Cited by 316 · see citing works

Centenary Lecture. Biomimetic chemistry

Breslow, R. (1972) · Chemical Society Reviews · doi:10.1039/cs9720100553 · Cited by 315 · see citing works

A chiroselective peptide replicator

Saghatelian, A., Yokobayashi, Y., Soltani, K., & Ghadiri, M. R. (2001) · Nature · doi:10.1038/35057238 · Cited by 310 · see citing works

Tinkering with Enzymes: What Are We Learning?

Knowles, J. R. (1987) · Science · doi:10.1126/science.3296192 · Cited by 306 · see citing works

Bridging Nonliving and Living Matter

Rasmussen, S., Chen, L., Nilsson, M., & Abe, S. (2003) · Artificial Life · doi:10.1162/106454603322392479 · Cited by 266 · see citing works

Synthesis, structure and activity of artificial, rationally designed catalytic polypeptides

Johnsson, K., Allemann, R. K., Widmer, H., & Benner, S. A. (1993) · Nature · doi:10.1038/365530a0 · Cited by 235 · see citing works

Regulation of Repressor Expression in λ

Eisen, H., Brachet, P., da Silva, L. P., & Jacob, F. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.66.3.855 · Cited by 230 · see citing works

Metabolic engineering for drug discovery and development

Khosla, C., & Keasling, J. D. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1256 · Cited by 208 · see citing works

The application of a modified nucleotide in aptamer selection: novel thrombin aptamers containing -(1 -pentynyl)-2′-deoxyuridine

Latham, J. A., Johnson, R., & Toole, J. J. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.14.2817 · Cited by 200 · see citing works

PNA Technology

Nielsen, P. E. (2004) · Molecular Biotechnology · doi:10.1385/mb:26:3:233 · Cited by 199 · see citing works

Novel DNA superstructures formed by telomere-like oligomers

Sen, D., & Gilbert, W. (1992) · Biochemistry · doi:10.1021/bi00116a011 · Cited by 175 · see citing works

Oligonucleotides containing flexible nucleoside analogs

Schneider, K. C., & Benner, S. A. (1990) · Journal of the American Chemical Society · doi:10.1021/ja00157a073 · Cited by 173 · see citing works

Protein Engineering

Ulmer, K. M. (1983) · Science · doi:10.1126/science.6572017 · Cited by 169 · see citing works

Design, synthesis, and characterization of a cytotoxic peptide with melittin-like activity

DeGrado, W. F., Kezdy, F. J., & Kaiser, E. T. (1981) · Journal of the American Chemical Society · doi:10.1021/ja00393a035 · Cited by 165 · see citing works

Recent advances in the chemistry of natural products

Woodward, R. B. (1968) · Pure and Applied Chemistry · doi:10.1351/pac196817030519 · Cited by 164 · see citing works

Nucleobase Pairing in Expanded Watson-Crick-like Genetic Information Systems

Geyer, C. R., Battersby, T. R., & Benner, S. A. (2003) · Structure · doi:10.1016/j.str.2003.11.008 · Cited by 159 · see citing works

A Comment on the Use of the Term Emergent Properties

Salt, G. W. (1979) · The American Naturalist · doi:10.1086/283370 · Cited by 157 · see citing works

The modular logic of signaling proteins: building allosteric switches from simple binding domains

Lim, W. A. (2002) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(02)00290-7 · Cited by 151 · see citing works

Complex early genes

Roy, S. W., & Gilbert, W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408355101 · Cited by 144 · see citing works

Betadoublet: de novo design, synthesis, and characterization of a beta-sandwich protein.

Quinn, T. P., Tweedy, N. B., Williams, R. W., Richardson, J. S., & Richardson, D. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8747 · Cited by 142 · see citing works

Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry

Dueber, J. E., Yeh, B. J., Bhattacharyya, R. P., & Lim, W. A. (2004) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2004.10.004 · Cited by 136 · see citing works

Ten Suggestions to Strengthen the Science of Ecology

Belovsky, G. E., Botkin, D. B., Crowl, T. A., Cummins, K. W., Franklin, J. F., Hunter, M. L., Joern, A., Lindenmayer, D. B., MacMahon, J. A., Margules, C. R., et al. (2004) · BioScience · doi:10.1641/0006-3568(2004)054[0345:tststs]2.0.co;2 · Cited by 135 · see citing works

Phosphates, DNA, and the Search for Nonterrean Life: A Second Generation Model for Genetic Molecules

Benner, S. A., & Hutter, D. (2002) · Bioorganic Chemistry · doi:10.1006/bioo.2001.1232 · Cited by 128 · see citing works

Quantitative Analysis of Receptors for Adenosine Nucleotides Obtained via In Vitro Selection from a Library Incorporating a Cationic Nucleotide Analog

Battersby, T. R., Ang, D. N., Burgstaller, P., Jurczyk, S. C., Bowser, M. T., Buchanan, D. D., Kennedy, R. T., & Benner, S. A. (1999) · Journal of the American Chemical Society · doi:10.1021/ja9816436 · Cited by 114 · see citing works

Starting from scratch

Ball, P. (2004) · Nature · doi:10.1038/431624a · Cited by 112 · see citing works

Recent advances in the chemistry of natural products

Woodward, R. B. (1971) · Pure and Applied Chemistry · doi:10.1351/pac197125010283 · Cited by 111 · see citing works

PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1

Sismour, A. M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh241 · Cited by 96 · see citing works

Multicenter Evaluation of the Performance Characteristics of the Bayer VERSANT HCV RNA 3.0 Assay (bDNA)

Elbeik, T., Surtihadi, J., Destree, M., Gorlin, J. B., Holodniy, M., Jortani, S. A., Kuramoto, K., Ng, V. L., Valdes, R., Valsamakis, A., et al. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.2.563-569.2004 · Cited by 95 · see citing works

Synthetic biology: Act natural

Benner, S. A. (2003) · Nature · doi:10.1038/421118a · Cited by 92 · see citing works

Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins

Howard, P. L., Chia, M. C., Rizzo, S. D., Liu, F., & Pawson, T. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1934711100 · Cited by 92 · see citing works

A complexity-based risk assessment of low-cost planetary missions: when is a mission too fast and too cheap?

Bearden, D. (2003) · Acta Astronautica · doi:10.1016/s0094-5765(02)00177-7 · Cited by 88 · see citing works

Engineering of Ralstonia eutropha for Production of Poly(3-hydroxybutyrate- co -3-hydroxyhexanoate) from Fructose and Solid-State Properties of the Copolymer

Fukui, T., Abe, H., & Doi, Y. (2002) · Biomacromolecules · doi:10.1021/bm0255084 · Cited by 87 · see citing works

Inverse Thinking about Double Mutants of Enzymes

Mildvan, A. S. (2004) · Biochemistry · doi:10.1021/bi048052e · Cited by 84 · see citing works

Crystal Structure of Double Helical Hexitol Nucleic Acids

Declercq, R., Aerschot, A. A. V., Read, R. J., Herdewijn, P. A., & Meervelt, L. V. (2002) · Journal of the American Chemical Society · doi:10.1021/ja016570w · Cited by 83 · see citing works

Crystal Structure of a B-Form DNA Duplex Containing ( l )-α-Threofuranosyl (3‘→2‘) Nucleosides: A Four-Carbon Sugar Is Easily Accommodated into the Backbone of DNA

Wilds, C. J., Wawrzak, Z., Krishnamurthy, R., Eschenmoser, A., & Egli, M. (2002) · Journal of the American Chemical Society · doi:10.1021/ja0207807 · Cited by 77 · see citing works

The past, present and future of molecular computing

Ruben, A. J., & Landweber, L. F. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036086 · Cited by 76 · see citing works

Expanding the Genetic Alphabet: Non-Epimerizing Nucleoside with the pyDDA Hydrogen-Bonding Pattern

Hutter, D., & Benner, S. A. (2003) · The Journal of Organic Chemistry · doi:10.1021/jo034900k · Cited by 69 · see citing works

Detecting Compensatory Covariation Signals in Protein Evolution Using Reconstructed Ancestral Sequences

Fukami-Kobayashi, K., Schreiber, D., & Benner, S. A. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00239-5 · Cited by 65 · see citing works

Analysis of the Role of the KMSKS Loop in the Catalytic Mechanism of the Tyrosyl-tRNA Synthetase Using Multimutant Cycles

First, E. A., & Fersht, A. R. (1995) · Biochemistry · doi:10.1021/bi00015a014 · Cited by 61 · see citing works

A trinucleotide can promote metal ion-dependent specific cleavage of RNA.

祐二, 有., & 幹, 直. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.7939 · Cited by 60 · see citing works

Density-functional theory for the freezing of water

Ding, K., Chandler, D., Smithline, S. J., & Haymet, A. D. J. (1987) · Physical Review Letters · doi:10.1103/physrevlett.59.1698 · Cited by 52 · see citing works

Interpreting the Behavior of Enzymes Purpose or Pedigree?

Benner, S. A., & Ellington, A. D. (1988) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238809082549 · Cited by 51 · see citing works

Poly(1-vinyluracil): The preparation and interactions with adenosine derivatives

Pitha, J., Pitha, P. M., & Ts’o, P. O. P. (1970) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(70)90488-0 · Cited by 48 · see citing works

Nucleophilic and general acid catalysis at physiological pH by a designed miniature esteraseElectronic supplementary information (ESI) available: NOESY and TOCSY spectra; Table with NMR assignments and observed NOEs; complete set of kinetic data for Art-Est catalysis; mass spectrum of fumaryl-Art-Est intermediate; rate constants for the spontaneous and catalysed ester hydrolysis. See http://www.rsc.org/suppdata/ob/b4/b404730c/. Coordinates for the structure of Art-Est have been deposited in the Brookhaven Protein Data Bank, code 1v1d.

Nicoll, A. J., & Allemann, R. K. (2004) · Organic & Biomolecular Chemistry · doi:10.1039/b404730c · Cited by 47 · see citing works

A de Novo Designed Peptide Ligase: A Mechanistic Investigation

Kennan, A. J., Haridas, V., Severin, K., Lee, D. H., & Ghadiri, M. R. (2001) · Journal of the American Chemical Society · doi:10.1021/ja991266c · Cited by 46 · see citing works

'Synthetic Biology' Makes Its Debut

RAWIS, R. L. (2000) · Chemical & Engineering News · doi:10.1021/cen-v078n017.p049 · Cited by 46 · see citing works

Artificial Genetic Systems: Exploiting the “Aromaticity” Formalism To Improve the Tautomeric Ratio for Isoguanosine Derivatives

Martinot, T. A., & Benner, S. A. (2004) · The Journal of Organic Chemistry · doi:10.1021/jo0497959 · Cited by 43 · see citing works

Escherichia coli DNA Polymerase I (Klenow Fragment) Uses a Hydrogen-bonding Fork from Arg668 to the Primer Terminus and Incoming Deoxynucleotide Triphosphate to Catalyze DNA Replication

Meyer, A. S., Blandino, M., & Spratt, T. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400232200 · Cited by 42 · see citing works

[Gene surgery: on the threshold of synthetic biology].

Hobom, B. (1980) · PubMed · Cited by 38 · see citing works

Redesigning Genetics

Benner, S. A. (2004) · Science · doi:10.1126/science.1101104 · Cited by 37 · see citing works

A Modular Assembly Strategy for Improving the Substrate Specificity of Small Catalytic Peptides

Tanaka, F., & Barbas, C. F. (2002) · Journal of the American Chemical Society · doi:10.1021/ja0171815 · Cited by 37 · see citing works

Synthetic DNA and Biology (Nobel Lecture)

Smith, M. J. (1994) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199412141 · Cited by 36 · see citing works

Simultaneous Runs of the Bayer VERSANT HIV-1 Version 3.0 and HCV bDNA Version 3.0 Quantitative Assays on the System 340 Platform Provide Reliable Quantitation and Improved Work Flow

Elbeik, T., Markowitz, N. P., NASSOS, P. S., Kumar, U., Beringer, S., Haller, B. L., & Ng, V. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.7.3120-3127.2004 · Cited by 35 · see citing works

Redesigning the Molecules of Life

Benner, S. A. (1988) · Springer eBooks · doi:10.1007/978-3-642-73594-3 · Cited by 34 · see citing works

A Hierarchic Approach to the Design of Hexameric Helical Barrels

Ghirlanda, G., Lear, J. D., Ogihara, N. L., Eisenberg, D. S., & DeGrado, W. F. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00233-4 · Cited by 33 · see citing works

EVOLUTIONARY DESIGN OF GENETIC CIRCUITS AND CELL-CELL COMMUNICATIONS

Yokobayashi, Y., Collins, C. H., Leadbetter, J. R., Arnold, F. H., & Weiss, R. (2003) · Advances in Complex Systems · doi:10.1142/s0219525903000700 · Cited by 31 · see citing works

Catalysts, Anticatalysts, and Receptors for Unactivated Phosphate Diesters in Water

Zepik, H. H., & Benner, S. A. (1999) · The Journal of Organic Chemistry · doi:10.1021/jo982418+ · Cited by 30 · see citing works

Recent advances in the design and construction of synthetic peptides: for the love of basics or just for the technology of it

Mayo, K. H. (2000) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01439-6 · Cited by 27 · see citing works

New directions in metabolic engineering

Jacobsen, J. R., & Khosla, C. (1998) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(98)80045-8 · Cited by 24 · see citing works

Protein Engineering of Detergent .ALPHA.-Amylases

Igarashi, K., Hagihara, H., & Ito, S. (2003) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.15.101 · Cited by 24 · see citing works

Design and biological activity of analogs of growth hormone releasing factor with potential amphiphilic helical carboxyl termini.

Veliçelebi, G., Patthi, S., & Kaiser, E. T. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.15.5397 · Cited by 23 · see citing works

X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture

Ali, M. H., Peisach, E., Allen, K. N., & Imperiali, B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401245101 · Cited by 21 · see citing works

Preprocessing of rotamers for protein design calculations

Shah, P. S., Hom, G. K., & Mayo, S. L. (2004) · Journal of Computational Chemistry · doi:10.1002/jcc.20097 · Cited by 19 · see citing works

Design of a folded, conformationally stable oxaloacetate decarboxylase

Taylor, S. E., Rutherford, T. J., & Allemann, R. K. (2002) · Journal of the Chemical Society Perkin Transactions 2 · doi:10.1039/b200057c · Cited by 18 · see citing works

Time for a Synthetic Biology Asilomar?

Ferber, D. (2004) · Science · doi:10.1126/science.303.5655.159 · Cited by 10 · see citing works

Synthetic life.

Gibbs, W. W. (2004) · PubMed · Cited by 8 · see citing works

Engineering Nonaqueous Solvent-Compatible Enzymes

Arnold, F. H., Chen, K., Economou, C., Chen, W., Martinez, P., Yoon, K. P., & Dam, M. E. V. (1993) · ACS symposium series · doi:10.1021/bk-1993-0516.ch008 · Cited by 5 · see citing works

Foundations for engineering biology

Endy, D. (2005) · Nature · doi:10.1038/nature04342 · Cited by 1,511 · see citing works

Gene Editing of <i>CCR5</i> in Autologous CD4 T Cells of Persons Infected with HIV

Tebas, P., Stein, D., Tang, W. W., Frank, I., Wang, S. Q., Lee, G., Spratt, S. K., Surosky, R. T., Giedlin, M. A., Nichol, G., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1300662 · Cited by 1,357 · see citing works

DNA as a universal substrate for chemical kinetics

Soloveichik, D., Seelig, G., & Winfree, E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909380107 · Cited by 695 · see citing works

Systems chemistry

Ludlow, R. F., & Otto, S. (2007) · Chemical Society Reviews · doi:10.1039/b611921m · Cited by 594 · see citing works

DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes

Zhang, R., & Lin, Y. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn858 · Cited by 504 · see citing works

A Synthetic Genetic Edge Detection Program

Tabor, J. J., Salis, H. M., Simpson, Z. B., Chevalier, A. A., Levskaya, A., Marcotte, E. M., Voigt, C. A., & Ellington, A. D. (2009) · Cell · doi:10.1016/j.cell.2009.04.048 · Cited by 485 · see citing works

Domains, Motifs, and Scaffolds: The Role of Modular Interactions in the Evolution and Wiring of Cell Signaling Circuits

Bhattacharyya, R. P., Reményi, A., Yeh, B. J., & Lim, W. A. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142710 · Cited by 449 · see citing works

Cell-free synthetic biology: Thinking outside the cell

Hodgman, C. E., & Jewett, M. C. (2011) · Metabolic Engineering · doi:10.1016/j.ymben.2011.09.002 · Cited by 426 · see citing works

Drug discovery beyond the ‘rule-of-five’

Zhang, M., & Wilkinson, B. M. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.10.005 · Cited by 421 · see citing works

Composability of regulatory sequences controlling transcription and translation in <i>Escherichia coli</i>

Kosuri, S., Goodman, D. B., Cambray, G., Mutalik, V. K., Gao, Y., Arkin, A. P., Endy, D., & Church, G. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301301110 · Cited by 392 · see citing works

C -Nucleosides: Synthetic Strategies and Biological Applications

Hocek, M. (2009) · Chemical Reviews · doi:10.1021/cr9002165 · Cited by 384 · see citing works

RNA synthetic biology

Isaacs, F. J., Dwyer, D. J., & Collins, J. J. (2006) · Nature Biotechnology · doi:10.1038/nbt1208 · Cited by 372 · see citing works

Gene Designer: a synthetic biology tool for constructing artificial DNA segments

Villalobos, A., Ness, J. E., Gustafsson, C., Minshull, J., & Govindarajan, S. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-285 · Cited by 378 · see citing works

Biomolecular computing systems: principles, progress and potential

Benenson, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3197 · Cited by 374 · see citing works

Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation

Li, J., Green, A. A., Yan, H., & Fan, C. (2017) · Nature Chemistry · doi:10.1038/nchem.2852 · Cited by 353 · see citing works

Reconstruction of genetic circuits

Sprinzak, D., & Elowitz, M. B. (2005) · Nature · doi:10.1038/nature04335 · Cited by 348 · see citing works

Synthetic biology—putting engineering into biology

Heinemann, M., & Panke, S. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl469 · Cited by 346 · see citing works

Emergent bistability by a growth-modulating positive feedback circuit

Tan, C., Marguet, P., & You, L. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.218 · Cited by 341 · see citing works

Construction of an in vitro bistable circuit from synthetic transcriptional switches

Kim, J., White, K. S., & Winfree, E. (2006) · Molecular Systems Biology · doi:10.1038/msb4100099 · Cited by 316 · see citing works

A Decade of Systems Biology

Chuang, H., Hofree, M., & Ideker, T. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100109-104122 · Cited by 316 · see citing works

Synthetic microbial ecosystems: an exciting tool to understand and apply microbial communities

Roy, K. D., Marzorati, M., den Abbeele, P. V., de Wiele, T. V., & Boon, N. (2013) · Environmental Microbiology · doi:10.1111/1462-2920.12343 · Cited by 312 · see citing works

Synthetic in vitro transcriptional oscillators

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Life as a Nanoscale Phenomenon

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Signatures of a Shadow Biosphere

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Medium Scale Integration of Molecular Logic Gates in an Automaton

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DMSO and Betaine Greatly Improve Amplification of GC-Rich Constructs in De Novo Synthesis

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Engineering Signal Transduction Pathways

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GeneGuard: A Modular Plasmid System Designed for Biosafety

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An Artificial Chromosome for Data Storage

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Nucleoside Phosphorylation by Phosphate Minerals

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Tradeoffs and Optimality in the Evolution of Gene Regulation

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Engineered E. coli That Detect and Respond to Gut Inflammation through Nitric Oxide Sensing

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Fluorescence-Activated Droplet Sorting for Single-Cell Directed Evolution

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Transcription of an Expanded Genetic Alphabet

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Alteration of Substrate Specificity: The Variable N-Terminal Domain of Tobacco Ca2+-Dependent Protein Kinase Is Important for Substrate Recognition

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Chemical Aspects of Synthetic Biology

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Toward β-Amino Acid Proteins: Design, Synthesis, and Characterization of a Fifteen Kilodalton β-Peptide Tetramer

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Synthesis at the Interface of Chemistry and Biology

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A synthetic low-frequency mammalian oscillator

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The Emerging World of Synthetic Genetics

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Synthetic biology, tinkering biology, and artificial biology. What are we learning?

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Synthetic Biology as a Proof of Systems Biology

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Synthetic Biology: A bit of rebranding, or something new and inspiring?

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Ashley Publications www.ashley-pub.com General Synthetic biology

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