Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata
Abstract
Licochalcone A, B, C, D and echinatin, retrochalcones isolated from the roots of Glycyrrhiza inflata (licorice), along with an ordinary chalcone isoliquiritigenin, were assessed for their inhibitory activities on lipid peroxidation in various systems and radical scavenging activity. Among those tested, licochalcones B and D strongly inhibited superoxide anion production in the xanthine/xanthine oxidase system. These two compounds also showed potent scavenging activity on DPPH radical. Microsomal lipid peroxidation induced by Fe(III)-ADP/NAPDH was inhibited almost completely by 3 micrograms/ml of licochalcones B and D. Mitochondrial lipid peroxidation induced by Fe(III)-ADP/NADH was more sensitive to these retrochalcones; almost complete inhibition was observed at 10 micrograms/ml of all retrochalcones tested. Licochalcones B and D scavenged superoxide anion in microsome. Furthermore, these retrochalcones protected red cells against oxidative hemolysis. These phenolic compounds were shown to be effective to protect biological systems against various oxidative stresses.
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Licochalcones B and D are effective in protecting biological systems against oxidative stress, being able to inhibit skin damage.
“These phenolic compounds appeared to be effective in protecting biological systems against oxidative stress, being able to inhibit skin damage [78,79].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [78]
Licochalcones B and D show strong scavenging activity in the DPPH assay and ability to inhibit microsomal lipid peroxidation.
“Licochalcones B and D showed a strong scavenging activity in the DPPH assay and the ability to inhibit microsomal lipid peroxidation.”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [78]
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Liquorice ( <scp> <i>Glycyrrhiza glabra</i> </scp> ): A phytochemical and pharmacological review
Pastorino, G., Cornara, L., Soares, S., Rodrigues, F., & Oliveira, M. B. P. P. (2018) · Phytotherapy Research · doi:10.1002/ptr.6178 · Cited by 804 · see citing works
Cerulli, A., Masullo, M., Montoro, P., & Piacente, S. (2022) · Cosmetics · doi:10.3390/cosmetics9010007 · Cited by 83 · see citing works
Kühnl, J., Roggenkamp, D., Gehrke, S. A., Stäb, F., Wenck, H., Kolbe, L., & Neufang, G. (2015) · Experimental Dermatology · doi:10.1111/exd.12588 · Cited by 56 · see citing works
- Authors
- Haraguchi, H., Ishikawa, H., Mizutani, K., Tamura, Y., & Kinoshita, T.
- Affiliations
- Fukuyama University (JP)
- Maruzen Pharmaceuticals Co., Ltd. (Japan) (JP)
- Teikyo University (JP)
- Corresponding author
- Haraguchi, Hiroyuki
- ORCID
- Kinoshita, Takeshi
- Venue
- Bioorganic & Medicinal Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 6
- Issue
- 3
- Pages
- 339-347
- ISSN
- 0968-0896 (ISSN-L)
- OpenAlex
- W2019643499
- Cited by
- 251
- References
- 0
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 6 · 2022: 9 · 2021: 13 · 2020: 9 · 2019: 7 · 2018: 13 · 2017: 9 · 2016: 14 · 2015: 9 · 2014: 16 · 2013: 16 · 2012: 9
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioorganic & Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- Glycyrrhiza inflata, licochalcone B, licochalcone A, echinatin, isoliquiritigenin, superoxide radical scavenging, lipid peroxidation inhibition, DPPH radical scavenging, xanthine-xanthine oxidase system, oxidative hemolysis, antioxidant activity, oxidative stress
- MeSH terms
- Animals, Antioxidants, Chalcone, Colorimetry, Glycyrrhiza, Humans, Male, Microsomes, Liver, Plant Extracts, Plants, Medicinal, Structure-Activity Relationship, Superoxides, Xanthine Oxidase, Lipid Peroxidation, Free Radical Scavengers, Rats, Wistar, Mice, Rats
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