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Cited by 162

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Hyperthermia following traumatic brain injury: a critical evaluation

Open access
Thompson, Hilaire J, Tkacs, Nancy C, Saatman, Kathryn E, Raghupathi, Ramesh, McIntosh, Tracy K·2003·Neurobiology of Disease

Abstract

Hyperthermia, frequently seen in patients following traumatic brain injury (TBI), may be due to posttraumatic cerebral inflammation, direct hypothalamic damage, or secondary infection resulting in fever. Regardless of the underlying cause, hyperthermia increases metabolic expenditure, glutamate release, and neutrophil activity to levels higher than those occurring in the normothermic brain-injured patient. This synergism may further compromise the injured brain, enhancing the vulnerability to secondary pathogenic events, thereby exacerbating neuronal damage. Although rigorous control of normal body temperature is the current standard of care for the brain-injured patient, patient management strategies currently available are often suboptimal and may be contraindicated. This article represents a compendium of published work regarding the state of knowledge of the relationship between hyperthermia and TBI, as well as a critical examination of current management strategies.

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Metadata

Authors
Thompson, H. J., Tkacs, N. C., Saatman, K. E., Raghupathi, R., & McIntosh, T. K.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2003-04
Volume
12
Issue
3
Pages
163-173
ISSN
0969-9961 (ISSN-L)
OpenAlex
W2054935811
Cited by
162
References
2
FWCI
4.14
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Hyperthermia following traumatic brain injury: a critical evaluation. https://app.cochat.ai/papers/10.1016/s0969-9961(02)00030-x
The paper
Thompson, H. J., Tkacs, N. C., Saatman, K. E., Raghupathi, R., & McIntosh, T. K. (2003). Hyperthermia following traumatic brain injury: a critical evaluation. Neurobiology of Disease. https://doi.org/10.1016/s0969-9961(02)00030-x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.