Cyclooxygenase Inhibition as a Strategy to Ameliorate Brain Injury

Hurley, Sean D.; Olschowka, John A.; O'Banion, M. Kerry

doi:10.1089/089771502753460196

Cited by 110Inflammatory mediators and NSAID effectsTraumatic Brain Injury and Neurovascular DisturbancesNeurological Disorders and Treatments

Cyclooxygenase Inhibition as a Strategy to Ameliorate Brain Injury

Hurley, Sean D., Olschowka, John A., O'Banion, M. Kerry·2002·Journal of Neurotrauma

DOI 10.1089/089771502753460196

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Abstract

Cyclooxygenase (COX) is the obligate, rate-limiting enzyme for the conversion of arachidonic acid into prostaglandins. Two COX enzymes have been identified: a constitutively expressed COX-1 and an inducible, highly regulated COX-2. Widely used to treat chronic inflammatory disorders, COX inhibitors have shown promise in attenuating inflammation associated with brain injury. However, the use of COX inhibition in the treatment of brain injury has met with mixed success. This review summarizes our current understanding of COX expression in the central nervous system and the effects of COX inhibitors on brain injury. Three major targets for COX inhibition in the treatment brain injury have been identified. These are the cerebrovasculature, COX-2 expression by vulnerable neurons, and the neuroinflammatory response. Evidence suggests that given the right treatment paradigm, COX inhibition can influence each of these three targets. Drug interactions and general considerations for administrative paradigms are also discussed. Although therapies targeted to specific prostaglandin species, such as PGE2, might prove more ameliorative for brain injury, at the present time non-specific COX inhibitors and COX-2 specific inhibitors are readily available to researchers and clinicians. We believe that COX inhibition will be a useful, ameliorative adjunct in the treatment of most forms of brain injury.

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From A statistical framework for high-content phenotypic profiling using cellular feature distributions (2022) · cites this paper as [41]

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Traumatic cerebral vascular injury: the effects of concussive brain injury on the cerebral vasculature
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A statistical framework for high-content phenotypic profiling using cellular feature distributions
Pearson, Y. E., Kremb, S., Butterfoss, G. L., Xie, X., Fahs, H., & Gunsalus, K. C. (2022) · Communications Biology · doi:10.1038/s42003-022-04343-3 · Cited by 19 · see citing works
“TA is an inhibitor of the enzyme cyclooxygenase (COX), also called prostaglandin-endoperoxide synthase (PTGS), which is involved in the conversion of fatty acids to prostaglandin 41 and is targeted by a variety of anti-in ﬂ ammatory drugs 42 .”

Authors: Hurley, S. D., Olschowka, J. A., & O'Banion, M. K.
Affiliations: University of Rochester Medicine (US)
Departments of Neurobiology and Anatomy, and Neurology, University of Rochester Medical Center, Rochester, New York
ORCID: Olschowka, John A.
Venue: Journal of Neurotrauma
Publisher: SAGE Publications
Published: 2002-01
Volume: 19
Issue: 1
Pages: 1-15
ISSN: 0897-7151 (ISSN-L)
1557-9042
DOI: 10.1089/089771502753460196
OpenAlex: W1980681889
Cited by: 110
References: 196
Citations by year: 2024: 2 · 2023: 2 · 2022: 2 · 2020: 1 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 1
FWCI: 1.39
Type: journal article
Language: en
Open access: closed
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Journal of Neurotrauma (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns038577-04, 5p01ca011051-29)
National Cancer Institute (CA11051-24)
National Institute of Neurological Disorders and Stroke (NS 33553, NS38577)
Topics: Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
Keywords: cyclooxygenase inhibition, brain injury, cyclooxygenase-2, cyclooxygenase-1, prostaglandins, neuroinflammation, cerebral vasculature, drug interactions, COX-2 inhibitors, arachidonic acid metabolism
MeSH terms: Animals, Brain Injuries, Humans, Cyclooxygenase Inhibitors

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Cyclooxygenase Inhibition as a Strategy to Ameliorate Brain Injury

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