Twenty-to-thirty-seven-year follow-up after repair for Tetralogy of Fallot.
Open accessAbstract
OBJECTIVE: To describe the long-term prognosis after repair of Tetralogy of Fallot with pulmonary stenosis beyond 20 years. METHODS: One hundred and eighty five patients underwent corrective repair of Tetralogy of Fallot at Rigshospitalet in Copenhagen between January 1960 and July 1977. Ninety seven patients had undergone a palliative operation prior to Tetralogy of Fallot repair. All the 125 patients who were discharged from the hospital were traced through the population register and the patients alive July 1997 were contacted by mail and/or telephone and questioned about use of medicine, professional status, family status and ability to perform sport activities. RESULTS: Sixty patients died in hospital and 125 patients, 78 males and 47 females, were discharged alive. Among operative survivors, median age at operation was 12.8 years (range 0.4-41 years). Thirteen patients required a reoperation, the main indication was failed VSD closure. There were 16 late cardiac deaths, out of which seven were sudden and unexpected and three were in immediate relation to reoperations. One hundred and nine patients were alive at follow-up. The mean follow-up time was 25.5 years (range 20-38 years). Sixteen percent used cardiac drugs, 89% were, or had been, working normally (all professions from academics to hard manual labors were represented), 53% (64% of women) had given birth after the repair and 51% performed sport activities regularly. No patients were lost to follow-up. CONCLUSIONS: The vast majority of the patients seemed to live normal lives 20-37 years after Tetralogy of Fallot repair. Late deaths were cardiac in origin, including sudden death from arrhythmias. The number of late reoperation has been low. Considering the natural history of the disease, Fallot repair has proven to be a beneficial procedure even including the very early experience short after introduction of open heart surgery.
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The rates of sudden death and heart failure in our cohort are similar to those reported in other studies.
“The rates of sudden death and heart failure in our cohort are similar to those reported in other studies.9,18”
From Long-term Outcomes of Tetralogy of Fallot: A Study From the Pediatric Cardiac Care Consortium (2019) · cites this paper as [18]
The Discussion reports seven late sudden deaths and says that incidence was identical to that in another study. Table 1 lists deaths involving heart failure, but our copy does not compare heart-failure rates with other studies. Nor can this source establish whether either rate is similar to the citing authors’ own cohort. (LLM, conf=0.82)
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- Authors
- Nørgaard, M. A., Lauridsen, P., Helvind, M., & Pettersson, G.
- Affiliations
- Rigshospitalet (DK)
- Corresponding author
- Nørgaard, Martin A.
- Venue
- European Journal of Cardio-Thoracic Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08
- Volume
- 16
- Issue
- 2
- Pages
- 125-130
- ISSN
- 1010-7940 (ISSN-L)
- 1873-734X
- OpenAlex
- W2165719631
- Cited by
- 134
- References
- 30
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 2 · 2022: 3 · 2021: 5 · 2019: 2 · 2018: 6 · 2017: 9 · 2016: 5 · 2015: 3 · 2014: 8 · 2013: 6 · 2012: 8
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Cardio-Thoracic Surgery (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Surgery › Cardiac Structural Anomalies and Repair
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- tetralogy of Fallot, pulmonary stenosis, long-term prognosis, surgical repair, sudden cardiac death, cardiac arrhythmias, reoperation, ventricular septal defect closure, sports participation, congenital heart disease
- MeSH terms
- Abnormalities, Multiple, Adolescent, Adult, Cause of Death, Child, Child, Preschool, Female, Follow-Up Studies, Cardiac Surgical Procedures, Humans, Infant, Infant, Newborn, Male, Middle Aged, Patient Discharge, Pulmonary Valve Stenosis, Quality of Life, Surveys and Questionnaires, Registries, Reoperation, Retrospective Studies, Tetralogy of Fallot, Survival Rate, Treatment Outcome, Hospital Mortality
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