Lipoatrophy Revisited

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093

A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors

Carr, A., Samaras, K., Burton, S., Law, M. G., Freund, J., Chisholm, D. J., & Cooper, D. A. (1998) · AIDS · doi:10.1097/00002030-199807000-00003 · Cited by 2,364

Environmental Contributions to the Obesity Epidemic

Hill, J. O., & Peters, J. C. (1998) · Science · doi:10.1126/science.280.5368.1371 · Cited by 2,258

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164

Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy

Bonne, G., di Barletta, M. R., Varnous, S., Bécane, H. M., Hammouda, E.-H., Merlini, L., Muntoni, F., Greenberg, C. R., Gary, F., Urtizberea, J. A., et al. (1999) · Nature Genetics · doi:10.1038/6799 · Cited by 1,384

Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease

Fatkin, D., MacRae, C. A., Sasaki, T., Wolff, M. R., Porcu, M., Frenneaux, M. P., Atherton, J. J., Vidaillet, H. J., Jr., Spudich, S., Girolami, U. D., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912023412302 · Cited by 1,366

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.

Halaas, J. L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D. A., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8878 · Cited by 1,033

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., & Brown, M. S. (1998) · Genes & Development · doi:10.1101/gad.12.20.3182 · Cited by 790

Thiazolidinediones

Yki-Järvinen, H. (2004) · New England Journal of Medicine · doi:10.1056/nejmra041001 · Cited by 1,830

Leptin-Replacement Therapy for Lipodystrophy

Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247

Fat Accumulation in the Liver Is Associated with Defects in Insulin Suppression of Glucose Production and Serum Free Fatty Acids Independent of Obesity in Normal Men

Seppala-Lindroos, A. (2002) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.7.3023 · Cited by 168

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14120 · Cited by 955

Type 2 diabetes across generations: from pathophysiology to prevention and management

Nolan, C. J., Damm, P., & Prentki, M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60614-4 · Cited by 923

Diabetes, Obesity, and the Brain

Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

Petersen, K. F., Oral, E. A., Dufour, S., Befroy, D., Ariyan, C., Yu, C., Cline, G. W., DePaoli, A. M., Taylor, S. I., Gorden, P., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215001 · Cited by 800

Fatty Liver

Kotronen, A., & Yki‐Järvinen, H. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.147538 · Cited by 793

Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass

Gavrilova, O., Haluzik, M., Matsusue, K., Cutson, J. J., Johnson, L., Dietz, K. R., Nicol, C. J., Vinson, C., Gonzalez, F. J., & Reitman, M. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300043200 · Cited by 707

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ

Garofalo, R. S., Orena, S. J., Rafidi, K., Torchia, A. J., Stock, J. L., Hildebrandt, A. L., Coskran, T., Black, S. C., Brees, D. J., Wicks, J. R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16885 · Cited by 726

Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin

Havel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575

Causes and Metabolic Consequences of Fatty Liver

Stefan, N., Kantartzis, K., & Häring, H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0009 · Cited by 536

Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity

Hammarstedt, A., Gogg, S., Hedjazifar, S., Nerstedt, A., & Smith, U. (2018) · Physiological Reviews · doi:10.1152/physrev.00034.2017 · Cited by 462

Adipocyte Differentiation: From Fibroblast to Endocrine Cell

Gregoire, F. M. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122601106 · Cited by 438

Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ

Savage, D. B., Tan, G. D., Acerini, C. L., Jebb, S. A., Agostini, M., Gurnell, M., Williams, R., Umpleby, A. M., Thomas, E. L., Bell, J. D., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.4.910 · Cited by 423

Insulin resistance and impaired adipogenesis

Gustafson, B., Hedjazifar, S., Gogg, S., Hammarstedt, A., & Smith, U. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.01.006 · Cited by 407

Leptin: Structure, Function and Biology

Zhang, F. P. Y., Chen, Y., Heiman, M. L., & DiMarchi, R. D. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)71012-8 · Cited by 353

Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk

Westerbacka, J., Corn�r, A., Tiikkainen, M., Tamminen, M., Vehkavaara, S., H�kkinen, A.-M., Fredriksson, J., & Yki-J�rvinen, H. (2004) · Diabetologia · doi:10.1007/s00125-004-1460-1 · Cited by 338

Variation in Type 2 Diabetes-Related Traits in Mouse Strains Susceptible to Diet-Induced Obesity

Rossmeisl, M., Rim, J. S., Koza, R. A., & Kozak, L. P. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1958 · Cited by 288

Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease

Qureshi, K. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i26.3540 · Cited by 283

Fat in the liver and insulin resistance

Yki‐Järvinen, H. (2005) · Annals of Medicine · doi:10.1080/07853890510037383 · Cited by 269

Visceral fat and metabolic inflammation: the portal theory revisited

Item, F., & Konrad, D. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01035.x · Cited by 287

Analysis of paradoxical observations on the association between leptin and insulin resistance

Ceddia, R. B., Koistinen, H. A., Zierath, J. R., & Sweeney, G. (2002) · The FASEB Journal · doi:10.1096/fj.02-0158rev · Cited by 258

Genotype-phenotype relationships in Berardinelli-Seip congenital lipodystrophy

Maldergem, L. V., Magré, J., Khallouf, T. E., Gedde‐Dahl, T., Délepine, M., Trygstad, O., Seemanová, E., Stephenson, T. J., Albott, C. S., Bonńici, F., et al. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.10.722 · Cited by 250

Leptin Function and Regulation

Zhang, Y., & Chua, S. C. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160041 · Cited by 284

Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?

Crux, N. B., & Elahi, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00832 · Cited by 248

Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy

Javor, E. D., Cochran, E. K., Musso, C., Young, J. R., DePaoli, A. M., & Gorden, P. (2005) · Diabetes · doi:10.2337/diabetes.54.7.1994 · Cited by 226

Hypoadiponectinemia Is Associated with Insulin Resistance, Hypertriglyceridemia, and Fat Redistribution in Human Immunodeficiency Virus-Infected Patients Treated with Highly Active Antiretroviral Therapy

Addy, C., Gavrila, A., Tsiodras, S., Brodovicz, K. G., Karchmer, A. W., & Mantzoros, C. S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020795 · Cited by 218

Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy

Vigouroux, C., Maachi, M., Nguyên, T.-H., Coussieu, C., Gharakhanian, S., Funahashi, T., Matsuzawa, Y., Shimomura, I., Rozenbaum, W., Capeau, J., et al. (2003) · AIDS · doi:10.1097/00002030-200307040-00011 · Cited by 210

Lipin Expression Preceding Peroxisome Proliferator-activated Receptor-γ Is Critical for Adipogenesis in Vivo and in Vitro

Phan, J., Péterfy, M., & Reue, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403506200 · Cited by 203

A Choline-Deficient Diet Exacerbates Fatty Liver but Attenuates Insulin Resistance and Glucose Intolerance in Mice Fed a High-Fat Diet

Raubenheimer, P. J., Nyirenda, M., & Walker, B. R. (2006) · Diabetes · doi:10.2337/db06-0097 · Cited by 199

WY14,643, a Peroxisome Proliferator-activated Receptor α (PPARα) Agonist, Improves Hepatic and Muscle Steatosis and Reverses Insulin Resistance in Lipoatrophic A-ZIP/F-1 Mice

Chou, C. J., Haluzı́k, M., Gregory, C., Dietz, K. R., Vinson, C., Gavrilova, O., & Reitman, M. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202449200 · Cited by 197

Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer?

Yang, X., & Smith, U. (2007) · Diabetologia · doi:10.1007/s00125-007-0640-1 · Cited by 197

FAT CELLS: Afferent and Efferent Messages Define New Approaches to Treat Obesity

Lafontan, M. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095843 · Cited by 191

Genetic Background (C57BL/6J Versus FVB/N) Strongly Influences the Severity of Diabetes and Insulin Resistance in ob/ob Mice

Haluzı́k, M., Colombo, C., Gavrilova, O., Chua, S. C., Wolf, N., Chen, M., STANNARD, B. S., Dietz, K. R., Roith, D. L., & Reitman, M. L. (2004) · Endocrinology · doi:10.1210/en.2004-0219 · Cited by 180

The Metabolic Syndrome: Peroxisome Proliferator-Activated Receptor γ and Its Therapeutic Modulation

Gurnell, M., Savage, D. B., Chatterjee, K., & O’Rahilly, S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030435 · Cited by 178

Plasma PAI-1 Levels Are More Strongly Related to Liver Steatosis Than to Adipose Tissue Accumulation

Alessi, M., Bastelica, D., Mavri, A., Morange, P., Berthet, B., Grino, M., & Juhan-Vague, I. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000077401.36885.bb · Cited by 178

Nutritional Supplementation Withtrans-10,cis-12–Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue

Poirier, H., Shapiro, J. S., Kim, R. J., & Lazar, M. A. (2006) · Diabetes · doi:10.2337/db06-0036 · Cited by 188

Predictors of Acquired Lipodystrophy in Juvenile-Onset Dermatomyositis and a Gradient of Severity

Bingham, A., Mamyrova, G., Rother, K. I., Oral, E. A., Cochran, E. K., Premkumar, A., Kleiner, D. E., James‐Newton, L., Targoff, I. N., Pandey, J. P., et al. (2008) · Medicine · doi:10.1097/md.0b013e31816bc604 · Cited by 173

Leptin and the Control of Metabolism: Role for Stearoyl-CoA Desaturase-1 (SCD-1)

Cohen, P., & Friedman, J. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.9.2455s · Cited by 165

The effect of underweight on female and male reproduction

Boutari, C., Pappas, P. D., Mintziori, G., Nigdelis, M. P., Athanasiadis, L., Goulis, D. G., & Mantzoros, C. S. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154229 · Cited by 181

HIV-1 Infection Alters Gene Expression in Adipose Tissue, Which Contributes to HIV-1/Haart-Associated Lipodystrophy

Giralt, M., Domingo, P., Guallar, J. P., de la Concepción, M. L. R., Alegre, M., Domingo, J. C., & Villarroya, F. (2006) · Antiviral Therapy · doi:10.1177/135965350601100610 · Cited by 155

Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy

Colombo, C., Cutson, J. J., Yamauchi, T., Vinson, C., Kadowaki, T., Gavrilova, O., & Reitman, M. L. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2727 · Cited by 147

Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs

Villanueva, C. J., Vergnes, L., Wang, J., Drew, B. G., Hong, C., Tu, Y., Hu, Y., Xu, P., Xu, F., Sáez, E., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.016 · Cited by 152

Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: A study in monozygotic and dizygotic twins

Makkonen, J., Pietiläinen, K. H., Rissanen, A., Kaprio, J. A., & Yki‐Järvinen, H. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.12.025 · Cited by 145

Clinical Effects of Long-Term Metreleptin Treatment in Patients With Lipodystrophy

Chan, J. L., Lutz, K., Cochran, E. K., Huang, W., Peters, Y., Weyer, C., & Görden, P. (2011) · Endocrine Practice · doi:10.4158/ep11229.or · Cited by 147

Mechanisms Regulating Adipocyte Expression of Resistin

Hartman, H. B., Hu, X., Tyler, K. X., Dalal, C. K., & Lazar, M. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201451200 · Cited by 145

A mutation in the peroxisome proliferator-activated receptor γ-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice

Olswang, Y., Cohen, H., Papo, O., Cassuto, H., Croniger, C. M., Hakimi, P., Tilghman, S. M., Hanson, R. W., & Reshef, L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022616299 · Cited by 137

Molecular mechanisms of central leptin resistance in obesity

Jung, C. H., & Kim, M.-S. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0020-y · Cited by 140

Lipoatrophic diabetes in Irs1−/−/Irs3−/− double knockout micePreprint

Laustsen, P. G., Michael, M. D., Crute, B. E., Cohen, S. E., Ueki, K., Kulkarni, R. N., Keller, S. R., Lienhard, G. E., & Kahn, C. R. (2002) · Genes & Development · doi:10.1101/gad.1034802 · Cited by 137

Lipin1 Is a Key Factor for the Maturation and Maintenance of Adipocytes in the Regulatory Network with CCAAT/Enhancer-binding Protein α and Peroxisome Proliferator-activated Receptor γ2

Koh, Y.-K., Lee, M.-Y., Kim, J. W., Kim, M., Moon, J., Lee, Y.-J., Ahn, Y., & Kim, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804007200 · Cited by 130

The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia

Mulligan, K., Khatami, H., Schwarz, J.-M., Sakkas, G. K., DePaoli, A. M., Tai, V. W., Wen, M. J., Lee, G. A., Grunfeld, C., & Schambelan, M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1588 · Cited by 127

Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Harrison, S. A., & Neuschwander‐Tetri, B. A. (2004) · Clinics in Liver Disease · doi:10.1016/j.cld.2004.06.008 · Cited by 115

Obesity therapy: altering the energy intake-and-expenditure balance sheet

Crowley, V., Yeo, G. S. H., & O’Rahilly, S. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd770 · Cited by 116

Lipolytic and thermogenic depletion of adipose tissue in cancer cachexia

Tsoli, M., Swarbrick, M. M., & Robertson, G. R. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.10.039 · Cited by 113

Adiponectin and Leptin Levels in HIV-Infected Subjects With Insulin Resistance and Body Fat Redistribution

Mynarcik, D. C., Combs, T. P., McNurlan, M. A., Scherer, P. E., Komaroff, E., & Gelato, M. C. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200212150-00009 · Cited by 113

p300 Coactivates the Adipogenic Transcription Factor CCAAT/Enhancer-binding Protein α

Erickson, R. L., Hemati, N., Ross, S. E., & MacDougald, O. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100128200 · Cited by 108

Leptin: obesity, diabetes and other peripheral effects - a review

Moran, O., & Phillip, M. (2003) · Pediatric Diabetes · doi:10.1034/j.1399-5448.2003.00017.x · Cited by 110

Long-term efficacy of leptin replacement in patients with Dunnigan-type familial partial lipodystrophy

Park, J. Y., Javor, E. D., Cochran, E. K., DePaoli, A. M., & Görden, P. (2007) · Metabolism · doi:10.1016/j.metabol.2006.11.010 · Cited by 103

Ectopic fat accumulation: an important cause of insulin resistance in humans.

Yki‐Järvinen, H. (2002) · Europe PMC (PubMed Central) · Cited by 101

Nuclear Envelope, Nuclear Lamina, and Inherited Disease

Worman, H. J., & Courvalin, J. (2005) · International review of cytology · doi:10.1016/s0074-7696(05)46006-4 · Cited by 102

Clinical Classification and Treatment of Congenital and Acquired Lipodystrophy

Chan, J. L., & Oral, E. A. (2010) · Endocrine Practice · doi:10.4158/ep09154.ra · Cited by 93

Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins

Pietiläinen, K. H., Rissanen, A., Kaprio, J. A., Mäkimattila, S., Häkkinen, A., Westerbacka, J., Sutinen, J., Vehkavaara, S., & Yki‐Järvinen, H. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00381.2004 · Cited by 90

Effects of fetal and neonatal exposure to nicotine on blood pressure and perivascular adipose tissue function in adult life

Gao, Y.-J., Holloway, A. C., Su, L.-Y., Takemori, K., Lü, C., & Lee, R. M. K. W. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.05.044 · Cited by 84

Prevalence of Mutations in AGPAT2 Among Human Lipodystrophies

Magré, J., Délepine, M., Maldergem, L. V., Robert, J., Maassen, J. A., Meier, M., Panz, V. R., Kim, C. A., Tubiana‐Rufi, N., Czernichow, P., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1573 · Cited by 84

Peroxisome Proliferator-Activated Receptors and Caloric Restriction—Common Pathways Affecting Metabolism, Health, and Longevity

Duszka, K., Gregor, A., Guillou, H., König, J. S., & Wahli, W. (2020) · Cells · doi:10.3390/cells9071708 · Cited by 86

PPARγ and metabolism: insights from the study of human genetic variants

Gurnell, M. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01767.x · Cited by 80

Diseases of adipose tissue: genetic and acquired lipodystrophies

Capeau, J., Magré, J., Lascols, O., Caron, M., Béréziat, V., Vigouroux, C., & Bastard, J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331073 · Cited by 78

Lipodystrophy in HIV 1-infected patients: lessons for obesity research

Villarroya, F., Domingo, P., & Giralt, M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803698 · Cited by 76

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance

Huynh, F. K., Levi, J., Denroche, H. C., Gray, S. L., Voshol, P. J., Neumann, U. H., Speck, M., Chua, S. C., Covey, S. D., & Kieffer, T. J. (2010) · Diabetes · doi:10.2337/db10-0074 · Cited by 79

Elevated Blood Pressure in Transgenic Lipoatrophic Mice and Altered Vascular Function

Takemori, K., Gao, Y., Ding, L., Lü, C., Su, L.-Y., An, W.-S., Vinson, C., & Lee, R. M. K. W. (2007) · Hypertension · doi:10.1161/01.hyp.0000255576.16089.b9 · Cited by 73

The influence of very-low-calorie diet on serum leptin, soluble leptin receptor, adiponectin and resistin levels in obese women

Anderlová, K., Křemen, J., Doležalová, R., Housova, J., Haluzíková, D., Kunešová, M., & Haluzı́k, M. (2006) · Physiological Research · doi:10.33549/physiolres.930779 · Cited by 69

Advances in the Understanding and Treatment of Nonalcoholic Fatty Liver Disease

Harrison, S. A., & Bisceglie, A. M. D. (2003) · Drugs · doi:10.2165/00003495-200363220-00001 · Cited by 69

Non-alcoholic Steatohepatitis in Children

Roberts, E. A. (2007) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.02.008 · Cited by 64

Sildenafil promotes adipogenesis through a PKG pathway

Zhang, X., Ji, J., Yan, G., Wu, J., Sun, X., Shen, J., Jiang, H., & Wang, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.064 · Cited by 63

Leptin in congenital and HIV-associated lipodystrophy

Tsoukas, M. A., Farr, O. M., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.017 · Cited by 58

Non-alcoholic fatty liver disease (NAFLD) in children

Eve, A. R. (2005) · Frontiers in bioscience · doi:10.2741/1699 · Cited by 57

Steatohepatitis in children

Roberts, E. A. (2002) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2002.0331 · Cited by 56

Chibby Promotes Adipocyte Differentiation through Inhibition of β-Catenin Signaling

Li, F., Singh, A. M., Mofunanya, A., Love, D. K., Terada, N., Moon, R. T., & Takemaru, K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01640-06 · Cited by 55

Lipodystrophy and severe metabolic dysfunction in mice with adipose tissue-specific insulin receptor ablation

Qiang, G., Kong, H. W., Xu, S., Pham, H. A., Parlee, S. D., Burr, A. A., Gil, V., Pang, J., Hughes, A., Gu, X., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.05.005 · Cited by 54

Growth hormone, insulin-like growth factor I, and leptin interaction in human cultured lutein granulosa cells steroidogenesis

Karamouti, M., Κollia, P., Kallitsaris, A., Vamvakopoulos, N., Kollios, G., & Messinis, I. E. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.08.076 · Cited by 52

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Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-?

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Opposite Effects of Background Genotype on Muscle and Liver Insulin Sensitivity of Lipoatrophic Mice

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Adrenalectomy Improves Diabetes in A-ZIP/F-1 Lipoatrophic Mice by Increasing Both Liver and Muscle Insulin Sensitivity

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Leptin: a novel therapeutic role in lipodystrophy

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Central obesity and altered peripheral adipose tissue gene expression characterize the NAFLD patient with insulin resistance: Role of nutrition and insulin challenge

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Nonalcoholic Fatty Liver Disease in Children

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A New Transgenic Rat Model of Hepatic Steatosis and the Metabolic Syndrome

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Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm

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Overview of clinical perspectives and mechanisms of obesity

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Leptin: a novel therapeutic role in lipodystrophy

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Acquired partial lipodystrophy is associated with increased risk for developing metabolic abnormalities

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What the Genetics of Lipodystrophy Can Teach Us About Insulin Resistance and Diabetes

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Lipoatrophic Diabetes in an Elderly Woman: Clinical Course and Serum Adipocytokine Concentrations

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Lipodystrophy: The experiment of nature to study leptin

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